Hadad CM

General

Full name : Hadad Christopher M

First name : Christopher M

Mail : Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio, 43210

Zip Code :

City :

Country : USA

Email : hadad.1@osu.edu

Phone :

Fax :

Website : \/\/research.cbc.osu.edu\/hadad.1\/

Directory :

References (15)

Title : Treatment of Organophosphorus Poisoning with 6-Alkoxypyridin-3-ol Quinone Methide Precursors: Resurrection of Methylphosphonate-Aged Acetylcholinesterase - Clay_2024_Chem.Res.Toxicol__
Author(s) : Clay WK , Buck AK , He Y , Hernandez Sanchez DN , Ward NA , Lear JM , Nguyen KQ , Clark BH , Sapia RJ , Lalisse RF , Sriraman A , Cadieux CL , McElroy CA , Callam CS , Hadad CM
Ref : Chemical Research in Toxicology , : , 2024
PubMedID: 38556765

Title : 4-Amidophenol Quinone Methide Precursors: Effective and Broad-Scope Nonoxime Reactivators of Organophosphorus-Inhibited Cholinesterases and Resurrectors of Organophosphorus-Aged Acetylcholinesterase - Lovins_2024_ACS.Chem.Neurosci__
Author(s) : Lovins AR , Miller KA , Buck AK , Ensey DS , Homoelle RK , Murtha MC , Ward NA , Shanahan LA , Gutti G , Shriwas P , McElroy CA , Callam CS , Hadad CM
Ref : ACS Chem Neurosci , : , 2024
PubMedID: 38621296

Title : A Novel, Modified Human Butyrylcholinesterase Catalytically Degrades the Chemical Warfare Nerve Agent, Sarin - McGarry_2020_Toxicol.Sci_174_133
Author(s) : McGarry KG , Lalisse RF , Moyer RA , Johnson KM , Tallan AM , Winters TP , Taris JE , McElroy CA , Lemmon EE , Shafaat HS , Fan Y , Deal A , Marguet SC , Harvilchuck JA , Hadad CM , Wood DW
Ref : Toxicol Sci , 174 :133 , 2020
PubMedID: 31879758

Title : Resurrection and Reactivation of Acetylcholinesterase and Butyrylcholinesterase - Franjesevic_2019_Chemistry_25_5337
Author(s) : Franjesevic AJ , Sillart SB , Beck JM , Vyas S , Callam CS , Hadad CM
Ref : Chemistry , 25 :5337 , 2019
PubMedID: 30444932

Title : Demonstration of In Vitro Resurrection of Aged Acetylcholinesterase after Exposure to Organophosphorus Chemical Nerve Agents - Zhuang_2018_J.Med.Chem_61_7034
Author(s) : Zhuang Q , Franjesevic AJ , Corrigan TS , Coldren WH , Dicken R , Sillart S , DeYong A , Yoshino N , Smith J , Fabry S , Fitzpatrick K , Blanton TG , Joseph J , Yoder RJ , McElroy CA , Ekici OD , Callam CS , Hadad CM
Ref : Journal of Medicinal Chemistry , 61 :7034 , 2018
PubMedID: 29870665

Title : Study of para-Quinone Methide Precursors toward the Realkylation of Aged Acetylcholinesterase - Yoder_2017_ACS.Med.Chem.Lett_8_622
Author(s) : Yoder RJ , Zhuang Q , Beck JM , Franjesevic AJ , Blanton TG , Sillart S , Secor T , Guerra L , Brown JD , Reid C , McElroy CA , Dogan Ekici O , Callam CS , Hadad CM
Ref : ACS Med Chem Lett , 8 :622 , 2017
PubMedID: 28626522

Title : Efforts toward treatments against aging of organophosphorus-inhibited acetylcholinesterase - Zhuang_2016_Ann.N.Y.Acad.Sci_1374_94
Author(s) : Zhuang Q , Young A , Callam CS , McElroy CA , Ekici OD , Yoder RJ , Hadad CM
Ref : Annals of the New York Academy of Sciences , 1374 :94 , 2016
PubMedID: 27327269

Title : Mechanistic Insights into the Hydrolysis of Organophosphorus Compounds by Paraoxonase-1: Exploring the Limits of Substrate Tolerance in a Promiscuous Enzyme - Muthukrishnan_2012_J.Phys.Org.Chem_25_1247
Author(s) : Muthukrishnan S , Shete VS , Sanan TT , Vyas S , Oottikkal S , Porter LM , Magliery TJ , Hadad CM
Ref : J Phys Org Chem , 25 :1247 , 2012
PubMedID: 23946555

Title : Butyrylcholinesterase and G116H, G116S, G117H, G117N, E197Q and G117H\/E197Q mutants: a molecular dynamics study - Vyas_2010_Chem.Biol.Interact_187_241
Author(s) : Vyas S , Beck JM , Xia S , Zhang J , Hadad CM
Ref : Chemico-Biological Interactions , 187 :241 , 2010
PubMedID: 20399202

Title : Computational Modeling of Human Paraoxonase 1: Preparation of Protein Models, Binding Studies, and Mechanistic Insights - Sanan_2010_J.Phys.Org.Chem_23_357
Author(s) : Sanan TT , Muthukrishnan S , Beck JM , Tao P , Hayes CJ , Otto TC , Cerasoli DM , Lenz DE , Hadad CM
Ref : J Phys Org Chem , 23 :357 , 2010
PubMedID: 24077808

Title : Gated molecular recognition and dynamic discrimination of guests - Rieth_2010_J.Am.Chem.Soc_132_773
Author(s) : Rieth S , Bao X , Wang BY , Hadad CM , Badjic JD
Ref : Journal of the American Chemical Society , 132 :773 , 2010
PubMedID: 20038142

Title : Reaction profiles of the interaction between sarin and acetylcholinesterase and the S203C mutant: model nucleophiles and QM\/MM potential energy surfaces - Beck_2010_Chem.Biol.Interact_187_220
Author(s) : Beck JM , Hadad CM
Ref : Chemico-Biological Interactions , 187 :220 , 2010
PubMedID: 20156428

Title : Chemical synthesis of two series of nerve agent model compounds and their stereoselective interaction with human acetylcholinesterase and human butyrylcholinesterase - Barakat_2009_Chem.Res.Toxicol_22_1669
Author(s) : Barakat NH , Zheng X , Gilley CB , MacDonald M , Okolotowicz K , Cashman JR , Vyas S , Beck JM , Hadad CM , Zhang J
Ref : Chemical Research in Toxicology , 22 :1669 , 2009
PubMedID: 19715346

Title : Reactivation of model cholinesterases by oximes and intermediate phosphyloximes: a computational study - Vyas_2008_Chem.Biol.Interact_175_187
Author(s) : Vyas S , Hadad CM
Ref : Chemico-Biological Interactions , 175 :187 , 2008
PubMedID: 18582852

Title : Hydrolysis of nerve agents by model nucleophiles: a computational study - Beck_2008_Chem.Biol.Interact_175_200
Author(s) : Beck JM , Hadad CM
Ref : Chemico-Biological Interactions , 175 :200 , 2008
PubMedID: 18538754