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NTE inhibitor

General

Neuropathy target esterase, Neurotoxic esterase (NTE) also known as patatin-like phospholipase domain-containing protein 6 (PNPLA6), is an esterase enzyme that in humans is encoded by the PNPLA6 gene. It is not an alpha/beta hydrolase but can be inhibited by organophosphates that inhibits also cholinesterases and carboxylesterases. The inhibition of NTE is responsible for neurodegeneration induced by organophosphorus compounds and chemical warfare agents.
Inhibitor Main targeted enzyme families Type Structure
S9B Organophosphate Cyclic OP NTE inhibitor Not AlphaBeta Hydrolase target Sulfur Compound Biotin derivative
Cyanofenphos ACHE Organophosphate NTE inhibitor Cyanide Not AlphaBeta Hydrolase target Sulfur Compound
DSF LYsophospholipase_carboxylesterase Acidic_Lipase Sulfur Compound Sulfonyl NTE inhibitor Not AlphaBeta Hydrolase target Lipase inhibitor
Phenyl-BDPO Organophosphate NTE inhibitor Cyclic OP Not AlphaBeta Hydrolase target
OBDPO Organophosphate NTE inhibitor Cyclic OP Not AlphaBeta Hydrolase target
EOPF Organophosphate NTE inhibitor Not AlphaBeta Hydrolase target FAAH inhibitor
CBDP ACHE BCHE Carb_B_Chordata Organophosphate Cyclic OP NTE inhibitor Not AlphaBeta Hydrolase target
DPDCVP Organophosphate NTE inhibitor Not AlphaBeta Hydrolase target
Dibutyl-dichlorovinyl-phosphate~DBVP Carb_B_Chordata Organophosphate NTE inhibitor Not AlphaBeta Hydrolase target
Phenyl-saligenin-phosphate~PSP BCHE Organophosphate Cyclic OP NTE inhibitor Not AlphaBeta Hydrolase target
Phenyl-di-n-pentylphosphinate Organophosphate NTE inhibitor Not AlphaBeta Hydrolase target
Phenyl-benzyl-carbamate Carbamate NTE inhibitor Not AlphaBeta Hydrolase target
DPPF Organophosphate NTE inhibitor Not AlphaBeta Hydrolase target
OSF Monoglyceridelipase_lysophospholip Sulfur Compound NTE inhibitor Not AlphaBeta Hydrolase target Sulfonyl
Tolserine ACHE BCHE Derivative of physostigmine-eserine Carbamate Indole NTE inhibitor Not AlphaBeta Hydrolase target