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NTE inhibitor

General

Neuropathy target esterase, Neurotoxic esterase (NTE) also known as patatin-like phospholipase domain-containing protein 6 (PNPLA6), is an esterase enzyme that in humans is encoded by the PNPLA6 gene. It is not an alpha/beta hydrolase but can be inhibited by organophosphates that inhibits also cholinesterases and carboxylesterases. The inhibition of NTE is responsible for neurodegeneration induced by organophosphorus compounds and chemical warfare agents.
Inhibitor Main targeted enzyme families Type Structure
Triphenyl-phosphite Carb_B_Chordata Organophosphorus flame retardant plasticizer Organophosphate Plasticizer OPIDN-OP NTE inhibitor
S9B Organophosphate Cyclic OP NTE inhibitor OPIDN-OP Not AlphaBeta Hydrolase target Sulfur Compound Biotin derivative
Hexyl-dcp Organophosphate Not AlphaBeta Hydrolase target OPIDN-OP NTE inhibitor Organochlorine
O-hexyl-O-2,5-dichlorophenyl-phosphoramidate Organophosphate Not AlphaBeta Hydrolase target OPIDN-OP NTE inhibitor Organochlorine
Cyanofenphos ACHE Organophosphate NTE inhibitor Cyanide Not AlphaBeta Hydrolase target Sulfur Compound OPIDN-OP
DSF LYsophospholipase_carboxylesterase Acidic_Lipase Sulfur Compound Sulfonyl NTE inhibitor Not AlphaBeta Hydrolase target Lipase inhibitor OPIDN-OP
Phenyl-BDPO Organophosphate NTE inhibitor Cyclic OP Not AlphaBeta Hydrolase target OPIDN-OP
OBDPO Organophosphate NTE inhibitor Cyclic OP Not AlphaBeta Hydrolase target OPIDN-OP
EOPF Organophosphate NTE inhibitor Not AlphaBeta Hydrolase target FAAH inhibitor OPIDN-OP
CBDP ACHE BCHE Carb_B_Chordata Organophosphate Cyclic OP NTE inhibitor Not AlphaBeta Hydrolase target OPIDN-OP
Chlorpyrifos ACHE Est9X Duf_3089 Carb_B_Arthropoda Trichloro Insecticide Organophosphate Sulfur Compound Organothiophosphate OPIDN-OP NTE inhibitor Organochlorine
DPDCVP Organophosphate NTE inhibitor Not AlphaBeta Hydrolase target OPIDN-OP
Dibutyl-dichlorovinyl-phosphate~DBVP Carb_B_Chordata Organophosphate NTE inhibitor Not AlphaBeta Hydrolase target OPIDN-OP
Leptophos ACHE Insecticide Organophosphate Sulfur Compound Organothiophosphate NTE inhibitor OPIDN-OP
Phenyl-saligenin-phosphate~PSP BCHE Organophosphate Cyclic OP NTE inhibitor Not AlphaBeta Hydrolase target OPIDN-OP
Phenyl-di-n-pentylphosphinate Organophosphate NTE inhibitor Not AlphaBeta Hydrolase target
Phenyl-benzyl-carbamate Carbamate NTE inhibitor Not AlphaBeta Hydrolase target
DPPF Organophosphate NTE inhibitor Not AlphaBeta Hydrolase target OPIDN-OP
OSF Monoglyceridelipase_lysophospholip Sulfur Compound NTE inhibitor Not AlphaBeta Hydrolase target Sulfonyl OPIDN-OP
Tolserine ACHE BCHE Derivative of physostigmine-eserine Stigmine Carbamate Indole NTE inhibitor Not AlphaBeta Hydrolase target OPIDN-OP
Tricresyl-phosphate ACHE BCHE Carb_B_Chordata Organophosphate Organophosphorus flame retardant plasticizer Plasticizer NTE inhibitor OPIDN-OP
Tri-o-cresylphosphate BCHE Organophosphate Organophosphorus flame retardant plasticizer Plasticizer NTE inhibitor OPIDN-OP