Farnesol
A sesquiterpenoid that has a role as a plant metabolite, a fungal metabolite and an antimicrobial agent trans,trans-Farnesol is a natural product || . Six terpenoids (farnesol, (-)--bisabolol, cis-nerolidol, trans-nerolidol, methyleugenol, (R)-(+)-limonene) ,are strong AChE inhibitors against An. funestus and An. arabiensis, while there was a moderate inhibitory activity against An. gambiae AChE, but very weak activity against An. coluzzii, and Electric eel AChE Rants'o et al.
General
Chemical_Nomenclature : (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol
Canonical SMILES : CC(=CCCC(=CCCC(=CCO)C)C)C
InChI : InChI=1S\/C15H26O\/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-16\/h7,9,11,16H,5-6,8,10,12H2,1-4H3\/b14-9+,15-11+
InChIKey : CRDAMVZIKSXKFV-YFVJMOTDSA-N
Other name(s) : trans,trans-Farnesol || (E,E)-Farnesol || (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol || CHEBI:16619 || CHEMBL25308
MW : 222.37
Formula : C15H26O
CAS_number : 106-28-5
PubChem : 445070
UniChem : CRDAMVZIKSXKFV-YFVJMOTDSA-N
Target
Families : Farnesol ligand of proteins in family
Fungal_carboxylesterase_lipase
Bacterial_lip_FamI.6
ACHE
Protein :
9pezi-q2tfw1
staau-lipas
anoga-ACHE1
References (10)
| Title : Neuroprotective mechanism of trans,trans-Farnesol in an ICV-STZ-induced rat model of Alzheimer's pathology - Kadian_2024_Inflammopharmacology__ |
| Author(s) : Kadian M , Saini N , Khera A , Kumar A |
| Ref : Inflammopharmacology , : , 2024 |
| Abstract : |
| PubMedSearch : Kadian_2024_Inflammopharmacology__ |
| PubMedID: 38308793 |
| Title : Effect of Quorum Sensing Molecule Farnesol on Mixed Biofilms of Candida albicans and Staphylococcus aureus - Gaalova-Radochova_2023_Antibiotics.(Basel)_12_441 |
| Author(s) : Gaalova-Radochova B , Kendra S , Jordao L , Kursawe L , Kikhney J , Moter A , Bujdakova H |
| Ref : Antibiotics (Basel) , 12 : , 2023 |
| Abstract : |
| PubMedSearch : Gaalova-Radochova_2023_Antibiotics.(Basel)_12_441 |
| PubMedID: 36978309 |
| Title : In vitro and in silico analysis of the Anopheles anticholinesterase activity of terpenoids - Rants'o_2022_Parasitol.Int_93_102713 |
| Author(s) : Rants'o TA , Koekemoer LL , van Zyl RL |
| Ref : Parasitol Int , 93 :102713 , 2022 |
| Abstract : |
| PubMedSearch : Rants'o_2022_Parasitol.Int_93_102713 |
| PubMedID: 36455706 |
| Title : Effect of quorum quenchers on virulence factors production and quorum sensing signalling pathway of non-mucoid, mucoid, and heavily mucoid Pseudomonas aeruginosa - Kalgudi_2022_World.J.Microbiol.Biotechnol_38_163 |
| Author(s) : Kalgudi R , Tamimi R , Kyazze G , Keshavarz T |
| Ref : World J Microbiol Biotechnol , 38 :163 , 2022 |
| Abstract : |
| PubMedSearch : Kalgudi_2022_World.J.Microbiol.Biotechnol_38_163 |
| PubMedID: 35835899 |
| Title : Antimicrobial, modulatory, and antibiofilm activity of tt-farnesol on bacterial and fungal strains of importance to human health - Lopes_2021_Bioorg.Med.Chem.Lett_47_128192 |
| Author(s) : Lopes AP , de Oliveira Castelo Branco RR , de Alcantara Oliveira FA , Campos MAS , de Carvalho Sousa B , Agostinho RC , Gonzalez AGM , Rocha JA , Pinheiro REE , Araujo AR , Dos Santos Soares MJ |
| Ref : Bioorganic & Medicinal Chemistry Lett , 47 :128192 , 2021 |
| Abstract : |
| PubMedSearch : Lopes_2021_Bioorg.Med.Chem.Lett_47_128192 |
| PubMedID: 34118413 |
| Title : The architecture of a mixed fungal-bacterial biofilm is modulated by quorum-sensing signals - Ruiz_2021_Environ.Microbiol_23_2433 |
| Author(s) : Ruiz A , Herraez M , Costa-Gutierrez SB , Molina-Henares MA , Martinez MJ , Espinosa-Urgel M , Barriuso J |
| Ref : Environ Microbiol , 23 :2433 , 2021 |
| Abstract : |
| PubMedSearch : Ruiz_2021_Environ.Microbiol_23_2433 |
| PubMedID: 33615654 |
| Title : Quorum-Sensing Mechanisms Mediated by Farnesol in Ophiostoma piceae: Effect on Secretion of Sterol Esterase - de Salas_2015_Appl.Environ.Microbiol_81_4351 |
| Author(s) : de Salas F , Martinez MJ , Barriuso J |
| Ref : Applied Environmental Microbiology , 81 :4351 , 2015 |
| Abstract : |
| PubMedSearch : de Salas_2015_Appl.Environ.Microbiol_81_4351 |
| PubMedID: 25888179 |
| Gene_locus related to this paper: 9pezi-q2tfw1 |
| Title : A new lipase as a pharmaceutical target for battling infections caused by Staphylococcus aureus: Gene cloning and biochemical characterization - Unlu_2015_Biotechnol.Appl.Biochem_62_642 |
| Author(s) : Unlu A , Tanriseven A , Sezen IY , Celik A |
| Ref : Biotechnol Appl Biochem , 62 :642 , 2015 |
| Abstract : |
| PubMedSearch : Unlu_2015_Biotechnol.Appl.Biochem_62_642 |
| PubMedID: 25385356 |
| Title : Sesquiterpene farnesol as a competitive inhibitor of lipase activity of Staphylococcus aureus - Kuroda_2007_FEMS.Microbiol.Lett_273_28 |
| Author(s) : Kuroda M , Nagasaki S , Ito R , Ohta T |
| Ref : FEMS Microbiology Letters , 273 :28 , 2007 |
| Abstract : |
| PubMedSearch : Kuroda_2007_FEMS.Microbiol.Lett_273_28 |
| PubMedID: 17559400 |
| Title : Effect of farnesol on Staphylococcus aureus biofilm formation and antimicrobial susceptibility - Jabra-Rizk_2006_Antimicrob.Agents.Chemother_50_1463 |
| Author(s) : Jabra-Rizk MA , Meiller TF , James CE , Shirtliff ME |
| Ref : Antimicrobial Agents & Chemotherapy , 50 :1463 , 2006 |
| Abstract : |
| PubMedSearch : Jabra-Rizk_2006_Antimicrob.Agents.Chemother_50_1463 |
| PubMedID: 16569866 |