Fungal_carboxylesterase_lipase

Relationship

Family: Fungal_carboxylesterase_lipase

Block: C

Parent Family: Carboxylesterase

Comment

This family was extracted from the previous Carboxylesterase COesterase family. Carboxylesterase, type B (COesterase) is very successful in fungi. Grouped with Lipase_3 in Family Fungal lipases in scop database. This family corresponds to the Carbohydrate Esterase family CE10 in CAZy - Carbohydrate-Active enZYmes database (CE_10) LED_Database abH03 abH02. The presence of a water/lipid interface dramatically enhances the hydrolytic activity of lipases. The activation is associated with a conformational change. The Ser-His-Asp/Glu catalytic triad is occluded by a polypeptide flap (lid) and is not exposed to the solvent until the lid is open. A protein of this family lacking the catalytic serine is a dirigent protein which controls the stereoselectivity of multicopper oxidase(VdtB)-catalyzed phenol coupling in viriditoxin biosynthesis (Hu et al. 2019)

Database

Interpro : IPR002018 Carboxylesterase, type B

PIRSF : PIRSF005676 COesterase

Pdoc : PDOC00112

Pfam : PF00135 COesterase

Prints : No Print

EC Number : 3.1.1.3

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (16)

Genes Proteins in Fungal_carboxylesterase_lipase family (4899)

Fragments of genes in Fungal_carboxylesterase_lipase family (1077)

Structures in Fungal_carboxylesterase_lipase family (16)

Substrates in Fungal_carboxylesterase_lipase family (27)

Inhibitors in Fungal_carboxylesterase_lipase family (5)

References (14)

Title : A Global Survey of Carbohydrate Esterase Families 1 and 10 in Oomycetes - de Vries_2020_Front.Genet_11_756
Author(s) : de Vries S , de Vries J
Ref : Front Genet , 11 :756 , 2020
PubMedID: 32849784

Title : Fungal Dirigent Protein Controls the Stereoselectivity of Multicopper Oxidase-Catalyzed Phenol Coupling in Viriditoxin Biosynthesis - Hu_2019_J.Am.Chem.Soc_141_8068
Author(s) : Hu J , Li H , Chooi YH
Ref : Journal of the American Chemical Society , 141 :8068 , 2019
PubMedID: 31045362
Gene_locus related to this paper: byssn-VdtD , byssp-vdta1

Title : Structural traits and catalytic versatility of the lipases from the Candida rugosa-like family: A review - Barriuso_2016_Biotechnol.Adv_34_874
Author(s) : Barriuso J , Vaquero ME , Prieto A , Martinez MJ
Ref : Biotechnol Adv , 34 :874 , 2016
PubMedID: 27188926

Title : Crystal structures of Ophiostoma piceae sterol esterase: Structural insights into activation mechanism and product release - Gutierrez-Fernandez_2014_J.Struct.Biol_187_215
Author(s) : Gutierrez-Fernandez J , Vaquero ME , Prieto A , Barriuso J , Martinez MJ , Hermoso JA
Ref : J Struct Biol , 187 :215 , 2014
PubMedID: 25108239
Gene_locus related to this paper: 9pezi-q2tfw1

Title : Insights into the molecular basis of chiral acid recognition by Candida rugosa lipase from an X-ray crystal structure of a bound phosphonate transition state analog - Colton_2011_Adv.Synth.Catal_353_2529
Author(s) : Colton IJ , Yin DT , Grochulski P , Kazlauskas RJ
Ref : Adv Synth Catal , 353 :2529 , 2011
PubMedID:
Gene_locus related to this paper: canru-1lipa

Title : Aspergillus niger protein EstA defines a new class of fungal esterases within the alpha\/beta hydrolase fold superfamily of proteins - Bourne_2004_Structure_12_677
Author(s) : Bourne Y , Hasper AA , Chahinian H , Juin M , De Graaff LH , Marchot P
Ref : Structure , 12 :677 , 2004
PubMedID: 15062090
Gene_locus related to this paper: aspni-EstA

Title : Defining substrate characteristics from 3D structure\; perspective on EstA structure - Schrag_2004_Structure.(Camb)_12_521
Author(s) : Schrag JD , Cygler M
Ref : Structure , 12 :521 , 2004
PubMedID: 15062074
Gene_locus related to this paper: aspni-EstA

Title : Structural insights into the lipase\/esterase behavior in the Candida rugosa lipases family: crystal structure of the lipase 2 isoenzyme at 1.97A resolution - Mancheno_2003_J.Mol.Biol_332_1059
Author(s) : Mancheno JM , Pernas MA , Martinez MJ , Ochoa B , Rua ML , Hermoso JA
Ref : Journal of Molecular Biology , 332 :1059 , 2003
PubMedID: 14499609
Gene_locus related to this paper: canru-2lipa

Title : Three-dimensional structure of homodimeric cholesterol esterase-ligand complex at 1.4 A resolution - Pletnev_2003_Acta.Crystallogr.D.Biol.Crystallogr_59_50
Author(s) : Pletnev V , Addlagatta A , Wawrzak Z , Duax W
Ref : Acta Crystallographica D Biol Crystallogr , 59 :50 , 2003
PubMedID: 12499539
Gene_locus related to this paper: canru-3lipa

Title : Structure of uncomplexed and linoleate-bound Candida cylindracea cholesterol esterase - Ghosh_1995_Structure_3_279
Author(s) : Ghosh D , Wawrzak Z , Pletnev VZ , Li N , Kaiser R , Pangborn W , Jornvall H , Erman M , Duax WL
Ref : Structure , 3 :279 , 1995
PubMedID: 7788294
Gene_locus related to this paper: canru-3lipa

Title : Analogs of reaction intermediates identify a unique substrate binding site in Candida rugosa lipase - Grochulski_1994_Biochemistry_33_3494
Author(s) : Grochulski P , Bouthillier F , Kazlauskas RJ , Serreqi AN , Schrag JD , Ziomek E , Cygler M
Ref : Biochemistry , 33 :3494 , 1994
PubMedID: 8142346
Gene_locus related to this paper: canru-1lipa

Title : A structural basis for the chiral preferences of lipases -
Author(s) : Cygler M , Grochulski P , Kazlauskas RJ , Schrag JD , Bouthillier F , Rubin B , Serreqi AN , Gupta AK
Ref : Journal of the American Chemical Society , 116 :3180 , 1994
PubMedID:
Gene_locus related to this paper: canru-1lipa

Title : 1.8 A refined structure of the lipase from Geotrichum candidum - Schrag_1993_J.Mol.Biol_230_575
Author(s) : Schrag JD , Cygler M
Ref : Journal of Molecular Biology , 230 :575 , 1993
PubMedID: 8464065
Gene_locus related to this paper: geoca-1lipa , geoca-2lipa

Title : Insights into interfacial activation from an open structure of Candida rugosa lipase - Grochulski_1993_J.Biol.Chem_268_12843
Author(s) : Grochulski P , Li Y , Schrag JD , Bouthillier F , Smith P , Harrison D , Rubin B , Cygler M
Ref : Journal of Biological Chemistry , 268 :12843 , 1993
PubMedID: 8509417
Gene_locus related to this paper: canru-1lipa , geoca-1lipa