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Bacterial_lip_FamI.6

Relationship

Family: Bacterial_lip_FamI.6

Block: L

Parent Family: Bacterial_lipase

Comment

This family correspond to family I.6 of the classification of Arpigny and Jaeger (1999). These lipases differ from other bacterial lipases. They present high phospholipase A1 activity. The substrate-binding cavity contains two large hydrophobic acyl chain-binding pockets and a shallow and more polar third pocket that is capable of binding either a (short) fatty acid or a phospholipid head-group.

Database

Interpro : No interpro

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : No Pfam

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour / coloured with Mview
Alignment with MAFFT No colour / coloured with Mview
Dendrogram The dnd file

Structure Name Proteins
8S9R SAL2, Staphylococcus aureus lipase 2 (geh, lip2), apo form staau-lipas
8K7Q Staphylococcus aureus lipase S116A inactive mutant-PSA (Petroselenic acid) complex staau-lipas
8K7P Staphylococcus aureus lipase-PSA (Petroselenic acid) complex staau-lipas
8YIB Staphylococcus aureus lipase -PSA (Petroselenic acid)- covalent complex staau-lipas
6KSI crystal structure of pathogenic Staphylococcus aureus lipase. Native staau-lipas
6KSL crystal structure of pathogenic Staphylococcus aureus lipase. Inactive S116A mutant staau-lipas
6KSM crystal structure of pathogenic Staphylococcus aureus lipase. SAL orlistat complex staau-lipas
2HIH Crystal structure of Staphylococcus hyicus lipase stahy-lipas

Gene_locus Name Species
lacca-ESTI Lactobacillus casei esterase Lactobacillus casei
staau-LIP Staphylococcus aureus (lipase) (triglyceride lipase)(EC 3.1.1.3) (tributyrase) SAL-1 sal1 geh Staphylococcus aureus
staau-lipas Staphylococcus aureus gene for lipase lip2, lipase 2, geh lipase. Glycerol ester hydrolase 2 gehB Staphylococcus simulans Staphylococcus aureus
staep-GEHD Staphylococcus epidermidis EH46 lipase precursor (EC 3.1.1.3) GehD SEL-2 serp2388 Staphylococcus epidermidis
staep-lipas Staphylococcus epidermidis gene for lipase SEL-3 geh1 serp2297 GehSE1 Staphylococcus epidermidis
staep-SE0245 Staphylococcus epidermidis triacylglycerol lipase precursor SERP2336 Staphylococcus epidermidis
staep-SE2403 Staphylococcus epidermidis glycerol ester hydrolase SERP0018 Staphylococcus epidermidis
staha-Q9RGZ6 Staphylococcus haemolyticus lipase L62 SHaL Staphylococcus haemolyticus
stahy-lipas Staphylococcus hyicus gene for lipase SHyL Staphylococcus hyicus
stawa-GEHA Staphylococcus warneri lipase SWL gehA Staphylococcus warneri
staxy-gehH Staphylococcus xylosus lipase precursor GehM (gehM) SXL gene Staphylococcus xylosus
staxy-q2tpv1 Staphylococcus xylosus Lipase SAL-2 geh Staphylococcus xylosus

Substrate Chemical Nomenclature Proteins
Sapienic-acid (Z)-hexadec-6-enoic acid staau-lipas
Palmitoleic-acid-alkyne (Z)-hexadec-9-en-15-ynoic acid staau-lipas
Cholesterol (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol staau-lipas
Paranitrophenyl-octanoate (4-nitrophenyl) octanoate 9firm-a0a0a0ymq9    9bact-Q0GMU2    psesp-OPH    human-NOTUM    pseae-PA2949    crysp-Q874E9    emeni-q5b2c1    fusso-cutas    thite-g2rae6    9flao-a0a330mq60    9flao-a0a0c1f4u8    malgo-a8puy1    9bact-6EB3    partm-GthFAE    9bact-a0a2h5z9r5    9actn-j7k890    9actn-j7kdc6    fusox-a0a1d3s5h0
Paranitrophenyl-palmitate (4-nitrophenyl) hexadecanoate malgo-a8qcw4    9pezi-s4vch4    crysp-Q874E9    pyrbr-Q9Y7G8    rhimi-lipas    cormm-g3j8e9    9gamm-a0a1b1ijp3    strex-SeLipC    staau-lipas
Tributyrin 2,3-di(butanoyloxy)propyl butanoate bovin-balip    rabit-1cxes    pseae-llipa    canar-LipB    human-PNLIPRP2    talth-f6lqk7    nech7-c7yuz1    cavpo-2plrp    human-CEL    human-PNLIP    canan-lipasA    rhimi-lipas    rhidl-lipas    psesp-Q9RBY1    staha-Q9RGZ6    9bact-6EB3
Tripropionin 2,3-di(propanoyloxy)propyl propanoate bovin-balip    rabit-1cxes    pseae-llipa    staha-Q9RGZ6
Trimyristin 2,3-di(tetradecanoyloxy)propyl tetradecanoate bacld-q65hr4    9gamm-q2ktb4    staha-Q9RGZ6

Inhibitor Chemical Nomenclature Proteins
Farnesol (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol 9pezi-q2tfw1    staau-lipas
Petroselenic-acid (Z)-octadec-6-enoic acid staau-lipas
l,2-Dioctylcarbamoylglycero-3-O-p-nitrophenyloctylphosphonate [3-[(4-nitrophenoxy)-octyl-oxidophosphaniumyl]oxy-2-(octylcarbamoyloxy)propyl] N-octylcarbamate fusso-cutas    stahy-lipas
Orlistat [(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl] (2S)-2-formamido-4-methylpentanoate human-DAGLA    human-DAGLB    human-PNLIP    human-FASN    mycs2-a0r619    human-PNLIPRP2    human-ABHD16A    myctu-a85c    myctu-Rv3822    plafa-PF10.0379    staau-lipas    human-CES2

References (3)

Title : Structural basis of phospholipase activity of Staphylococcus hyicus lipase - Tiesinga_2007_J.Mol.Biol_371_447
Author(s) : Tiesinga JJ , van Pouderoyen G , Nardini M , Ransac S , Dijkstra BW
Ref : Journal of Molecular Biology , 371 :447 , 2007
Abstract :
PubMedSearch : Tiesinga_2007_J.Mol.Biol_371_447
PubMedID: 17582438
Gene_locus related to this paper: stahy-lipas

Title : Lipases for biotechnology - Jaeger_2002_Curr.Opin.Biotechnol_13_390
Author(s) : Jaeger KE , Eggert T
Ref : Curr Opin Biotechnol , 13 :390 , 2002
Abstract :
PubMedSearch : Jaeger_2002_Curr.Opin.Biotechnol_13_390
PubMedID: 12323363

Title : Bacterial lipolytic enzymes: classification and properties - Arpigny_1999_Biochem.J_343_177
Author(s) : Arpigny JL , Jaeger KE
Ref : Biochemical Journal , 343 :177 , 1999
Abstract :
PubMedSearch : Arpigny_1999_Biochem.J_343_177
PubMedID: 10493927