Fluoride

"The fluoride variant of human butyrylcholinesterase owes its name to the observation that it is resistant to inhibition by 0.050 mM sodium fluoride in the in vitro assay. Individuals who are heterozygous for the fluoride and atypical alleles experience about 30 min of apnea, rather than the usual 3-5 min, after receiving succinyldicholine. These mutants correspond to L330I_human-BCHE, T243M_human-BCHE, G390V_human-BCHE Entry of reference human-BCHE"

General

Type : Natural,Inorganic chemicals

Chemical_Nomenclature : F-

Canonical SMILES : [F-]

InChI : InChI=1S\/FH\/h1H\/p-1

InChIKey : KRHYYFGTRYWZRS-UHFFFAOYSA-M

Other name(s) : SodiumFluoride,Sodium fluoride,Fluoride,Perfluoride,Fluoride ion,Fluorine, ion


MW : 18.99 || 41.99

Formula : F- || NaF

CAS_number : 16984-48-8 || 7681-49-4

PubChem : 28179, 5235

UniChem : KRHYYFGTRYWZRS-UHFFFAOYSA-M

IUPHAR :

Wikipedia : Fluoride

Target

Families : Fluoride ligand of proteins in family: BCHE

Stucture :

Protein : human-BCHE

References (13)

Title : Actions of sodium fluoride on acetylcholinesterase activities in rats - Zhao_1998_Biomed.Environ.Sci_11_1
Author(s) : Zhao XL , Wu JH
Ref : Biomedical & Environmental Sciences , 11 :1 , 1998
Abstract : Zhao_1998_Biomed.Environ.Sci_11_1
ESTHER : Zhao_1998_Biomed.Environ.Sci_11_1
PubMedSearch : Zhao_1998_Biomed.Environ.Sci_11_1
PubMedID: 9559097

Title : Butyrylcholinesterase genes in individuals with abnormal inhibition numbers and with trace activity: one common mutation and two novel silent genes - Dey_1998_Ann.Clin.Biochem_35_302
Author(s) : Dey DC , Maekawa M , Sudo K , Kanno T
Ref : Annals of Clinical Biochemistry , 35 :302 , 1998
Abstract : Dey_1998_Ann.Clin.Biochem_35_302
ESTHER : Dey_1998_Ann.Clin.Biochem_35_302
PubMedSearch : Dey_1998_Ann.Clin.Biochem_35_302
PubMedID: 9547905
Gene_locus related to this paper: human-BCHE

Title : Human butyrylcholinesterase L330I mutation belongs to a fluoride-resistant gene, by expression in human fetal kidney cells - Sudo_1997_Biochem.Biophys.Res.Commun_240_372
Author(s) : Sudo K , Maekawa M , Akizuki S , Magara T , Ogasawara H , Tanaka T
Ref : Biochemical & Biophysical Research Communications , 240 :372 , 1997
Abstract : Sudo_1997_Biochem.Biophys.Res.Commun_240_372
ESTHER : Sudo_1997_Biochem.Biophys.Res.Commun_240_372
PubMedSearch : Sudo_1997_Biochem.Biophys.Res.Commun_240_372
PubMedID: 9388484
Gene_locus related to this paper: human-BCHE

Title : Identification of human plasma cholinesterase variants in 6,688 individuals using biochemical analysis - Jensen_1995_Acta.Anaesthesiol.Scand_39_157
Author(s) : Jensen FS , Skovgaard LT , Viby-Mogensen J
Ref : Acta Anaesthesiologica Scandinavica , 39 :157 , 1995
Abstract : Jensen_1995_Acta.Anaesthesiol.Scand_39_157
ESTHER : Jensen_1995_Acta.Anaesthesiol.Scand_39_157
PubMedSearch : Jensen_1995_Acta.Anaesthesiol.Scand_39_157
PubMedID: 7793180

Title : Plasma cholinesterase: gene and variations - Pantuck_1993_Anesth.Analg_77_380
Author(s) : Pantuck EJ
Ref : Anesthesia & Analgesia , 77 :380 , 1993
Abstract : Pantuck_1993_Anesth.Analg_77_380
ESTHER : Pantuck_1993_Anesth.Analg_77_380
PubMedSearch : Pantuck_1993_Anesth.Analg_77_380
PubMedID: 8346840

Title : Recombinant human butyrylcholinesterase G390V, the fluoride-2 variant, expressed in Chinese hamster ovary cells, is a low affinity variant - Masson_1993_J.Biol.Chem_268_14329
Author(s) : Masson P , Adkins S , Gouet P , Lockridge O
Ref : Journal of Biological Chemistry , 268 :14329 , 1993
Abstract : Masson_1993_J.Biol.Chem_268_14329
ESTHER : Masson_1993_J.Biol.Chem_268_14329
PubMedSearch : Masson_1993_J.Biol.Chem_268_14329
PubMedID: 8314794

Title : Identification of two different point mutations associated with the fluoride-resistant phenotype for human butyrylcholinesterase - Nogueira_1992_Am.J.Hum.Genet_51_821
Author(s) : Nogueira CP , Bartels CF , McGuire MC , Adkins S , Lubrano T , Rubinstein HM , Lightstone H , van der Spek AF , Lockridge O , La Du BN
Ref : American Journal of Human Genetics , 51 :821 , 1992
Abstract : Nogueira_1992_Am.J.Hum.Genet_51_821
ESTHER : Nogueira_1992_Am.J.Hum.Genet_51_821
PubMedSearch : Nogueira_1992_Am.J.Hum.Genet_51_821
PubMedID: 1415224

Title : Malignant hyperthermia and the fluoride-resistant gene - Whittaker_1981_Br.J.Anaesth_53_241
Author(s) : Whittaker M , Britten JJ
Ref : British Journal of Anaesthesia , 53 :241 , 1981
Abstract : Whittaker_1981_Br.J.Anaesth_53_241
ESTHER : Whittaker_1981_Br.J.Anaesth_53_241
PubMedSearch : Whittaker_1981_Br.J.Anaesth_53_241
PubMedID: 7470359

Title : Increased sensitivity to succinylcholine in a patient heterozygous for the silent and the fluoride-resistant gene - Viby-Mogensen_1978_Anesth.Analg_57_422
Author(s) : Viby-Mogensen J , Hanel HK
Ref : Anesthesia & Analgesia , 57 :422 , 1978
Abstract : Viby-Mogensen_1978_Anesth.Analg_57_422
ESTHER : Viby-Mogensen_1978_Anesth.Analg_57_422
PubMedSearch : Viby-Mogensen_1978_Anesth.Analg_57_422
PubMedID: 568403

Title : The pseudocholinesterase variants. A family segregating for two homozygotes with the fluoride resistant gene -
Author(s) : Whittaker M , Berry M
Ref : Hum Hered , 22 :243 , 1972
PubMedID: 4562379

Title : The frequency of the fluoride resistant gene in a population of British students -
Author(s) : Whittaker M
Ref : Acta Genet Stat Med , 18 :563 , 1968
PubMedID: 5756527

Title : Effect of fluoride on the reaction of acetylcholinesterase with dimethylcarbamylcholine -
Author(s) : Greenspan CM , Wilson IB
Ref : Federation Proceedings , 26 :448 , 1967
PubMedID:

Title : Action of fluoride on cholinesterase. I. On the mechanism of inhibition -
Author(s) : Heilbronn E
Ref : Acta Chemica Scandinavica , 19 :1333 , 1965
PubMedID: 5850143