Geneseroline
not a carbamate. product of degradation of geneserine. Leaving group of ganstigmine
General
Type : Natural, Indole, Derivative of physostigmine-eserine, Leaving group
Chemical_Nomenclature : (4aS,9aS)-2,4a,9-trimethyl-4,9a-dihydro-3H-oxazino[6,5-b]indol-6-ol
Canonical SMILES : CC12CCN(OC1N(C3=C2C=C(C=C3)O)C)C
InChI : InChI=1S\/C13H18N2O2\/c1-13-6-7-14(2)17-12(13)15(3)11-5-4-9(16)8-10(11)13\/h4-5,8,12,16H,6-7H2,1-3H3\/t12-,13-\/m0\/s1
InChIKey : OPAXVHIAQIXNAM-STQMWFEESA-N
Other name(s) : (4aS-cis)-2,3,4,4a,9,9a-Hexahydro-2,4a,9-trimethyl-1,2-oxazino(6,5-b)indol-6-ol || 1,2-Oxazino(6,5-b)indol-6-ol, 2,3,4,4a,9,9a-hexahydro-2,4a,9-trimethyl-, (4aS-cis)-
MW : 234.294
Formula : C13H18N2O2
CAS_number : 123871-10-3
PubChem : 3083020
UniChem : OPAXVHIAQIXNAM-STQMWFEESA-N
Target
References (3)
| Title : Structural determinants of Torpedo californica acetylcholinesterase inhibition by the novel and orally active carbamate based anti-alzheimer drug ganstigmine (CHF-2819) - Bartolucci_2006_J.Med.Chem_49_5051 |
| Author(s) : Bartolucci C , Siotto M , Ghidini E , Amari G , Bolzoni PT , Racchi M , Villetti G , Delcanale M , Lamba D |
| Ref : Journal of Medicinal Chemistry , 49 :5051 , 2006 |
| Abstract : |
| PubMedSearch : Bartolucci_2006_J.Med.Chem_49_5051 |
| PubMedID: 16913695 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Characterization of Ganstigmine metabolites in hepatocytes by low- and high-resolution mass spectrometry coupled with liquid chromatography - Pelizzi_2003_Rapid.Commun.Mass.Spectrom_17_1691 |
| Author(s) : Pelizzi N , Puccini P , Riccardi B , Acerbi D , Catinella S |
| Ref : Rapid Commun Mass Spectrom , 17 :1691 , 2003 |
| Abstract : |
| PubMedSearch : Pelizzi_2003_Rapid.Commun.Mass.Spectrom_17_1691 |
| PubMedID: 12872272 |
| Title : Phase I metabolism of ganstigmine. Rat, dog, monkey and human liver microsomal extracts investigated by liquid chromatography electrospray tandem mass spectrometry - Catinella_2001_J.Mass.Spectrom_36_1287 |
| Author(s) : Catinella S , Pelizzi N , Puccini P , Marchetti S , Zanol M , Acerbi D , Ventura P |
| Ref : J Mass Spectrom , 36 :1287 , 2001 |
| Abstract : |
| PubMedSearch : Catinella_2001_J.Mass.Spectrom_36_1287 |
| PubMedID: 11754120 |