HY-148573
sEH human-EPHX2 IC50 0.39 nM
General
Type : Trifluoro, Urea derivative, Benzoxazol
Chemical_Nomenclature : 1-(2-oxo-3H-1,3-benzoxazol-5-yl)-3-[[2-(trifluoromethoxy)phenyl]methyl]urea || 3-(2-Oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-1-{[2-(trifluoromethoxy)phenyl]methyl}urea
Canonical SMILES : C1=CC=C(C(=C1)CNC(=O)NC2=CC3=C(C=C2)OC(=O)N3)OC(F)(F)F
InChI : InChI=1S\/C16H12F3N3O4\/c17-16(18,19)26-12-4-2-1-3-9(12)8-20-14(23)21-10-5-6-13-11(7-10)22-15(24)25-13\/h1-7H,8H2,(H,22,24)(H2,20,21,23)
InChIKey : IBPYKXOYNPPXBW-UHFFFAOYSA-N
Other name(s) : sEH inhibitor-14 || HY-148573 || CS-0636660 || Compound 33
MW : 367.28
Formula : C16H12F3N3O4
CAS_number : 2890221-26-6
PubChem : 166642356
UniChem : IBPYKXOYNPPXBW-UHFFFAOYSA-N
Target
Families : HY-148573 ligand of proteins in family
Epoxide_hydrolase
Protein :
human-EPHX2
References (1)
| Title : Benzoxazolone-5-Urea Derivatives as Human Soluble Epoxide Hydrolase (sEH) Inhibitors - Gur_2023_ACS.Omega_8_2445 |
| Author(s) : Gur Maz T , Koc B , Jordan PM , Ibis K , Caliskan B , Werz O , Banoglu E |
| Ref : ACS Omega , 8 :2445 , 2023 |
| Abstract : |
| PubMedSearch : Gur_2023_ACS.Omega_8_2445 |
| PubMedID: 36687110 |