| Title : 5-methyl-2-carboxamidepyrrole-based novel dual mPGES-1\/sEH inhibitors as promising anticancer candidates - Colarusso_2025_Arch.Pharm.(Weinheim)_358_e2400708 |
| Author(s) : Colarusso E , Lauro G , Potenza M , Galatello P , Garigliota MLD , Ferraro MG , Piccolo M , Chini MG , Irace C , Campiglia P , Hoffstetter RK , Werz O , Ramunno A , Bifulco G |
| Ref : Arch Pharm (Weinheim) , 358 :e2400708 , 2025 |
| Abstract : |
| PubMedSearch : Colarusso_2025_Arch.Pharm.(Weinheim)_358_e2400708 |
| PubMedID: 39692230 |
| Title : Repositioning of Small Molecules through the Inverse Virtual Screening in silico Tool: Case of Benzothiazole-Based Inhibitors of Soluble Epoxide Hydrolase (sEH) - Gazzillo_2024_Chempluschem__e202400234 |
| Author(s) : Gazzillo E , Colarusso E , Giordano A , Chini MG , Potenza M , Hofstetter RK , Iorizzi M , Werz O , Lauro G , Bifulco G |
| Ref : Chempluschem , :e202400234 , 2024 |
| Abstract : |
| PubMedSearch : Gazzillo_2024_Chempluschem__e202400234 |
| PubMedID: 38753468 |
| Title : Benzoxazolone-5-Urea Derivatives as Human Soluble Epoxide Hydrolase (sEH) Inhibitors - Gur_2023_ACS.Omega_8_2445 |
| Author(s) : Gur Maz T , Koc B , Jordan PM , Ibis K , Caliskan B , Werz O , Banoglu E |
| Ref : ACS Omega , 8 :2445 , 2023 |
| Abstract : |
| PubMedSearch : Gur_2023_ACS.Omega_8_2445 |
| PubMedID: 36687110 |
| Title : Novel thiazolopyridine derivatives of diflapolin as dual sEH\/FLAP inhibitors with improved solubility - Schoenthaler_2023_Bioorg.Chem_139_106685 |
| Author(s) : Schoenthaler M , Waltl L , Hasenoehrl T , Seher D , Lutz A , Aulinger L , Temml V , Konig S , Siller A , Braun DE , Garscha U , Werz O , Schuster D , Schennach H , Koeberle A , Matuszczak B |
| Ref : Bioorg Chem , 139 :106685 , 2023 |
| Abstract : |
| PubMedSearch : Schoenthaler_2023_Bioorg.Chem_139_106685 |
| PubMedID: 37418786 |
| Title : Design, Synthesis, and Pharmacological Characterization of a Potent Soluble Epoxide Hydrolase Inhibitor for the Treatment of Acute Pancreatitis - Musella_2023_J.Med.Chem__ |
| Author(s) : Musella S , D'Avino D , Peltner LK , Di Sarno V , Cerqua I , Merciai F , Vestuto V , Ciaglia T , Smaldone G , Di Matteo F , Di Micco S , Napolitano V , Bifulco G , Pepe G , Sommella EM , Basilicata MG , Aquino G , Gomez-Monterrey IM , Campiglia P , Ostacolo C , Roviezzo F , Werz O , Rossi A , Bertamino A |
| Ref : Journal of Medicinal Chemistry , : , 2023 |
| Abstract : |
| PubMedSearch : Musella_2023_J.Med.Chem__ |
| PubMedID: 37334504 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Repositioning of Quinazolinedione-Based Compounds on Soluble Epoxide Hydrolase (sEH) through 3D Structure-Based Pharmacophore Model-Driven Investigation - Gazzillo_2022_Molecules_27_ |
| Author(s) : Gazzillo E , Terracciano S , Ruggiero D , Potenza M , Chini MG , Lauro G , Fischer K , Hofstetter RK , Giordano A , Werz O , Bruno I , Bifulco G |
| Ref : Molecules , 27 : , 2022 |
| Abstract : |
| PubMedSearch : Gazzillo_2022_Molecules_27_ |
| PubMedID: 35744994 |
| Title : Discovery and optimization of piperazine urea derivatives as soluble epoxide hydrolase (sEH) inhibitors - Capan_2022_ChemMedChem__ |
| Author(s) : Capan I , Jordan PM , Olgac A , Caliskan B , Kretzer C , Werz O , Banoglu E |
| Ref : ChemMedChem , : , 2022 |
| Abstract : |
| PubMedSearch : Capan_2022_ChemMedChem__ |
| PubMedID: 35466565 |
| Title : Synthesis and structure-activity relationships for some novel diflapolin derivatives with benzimidazole subunit - Vieider_2022_J.Enzyme.Inhib.Med.Chem_37_1752 |
| Author(s) : Vieider L , Zoeller E , Romp E , Schoenthaler M , Hernandez-Olmos V , Temml V , Hasenoehrl T , Schuster D , Werz O , Garscha U , Matuszczak B |
| Ref : J Enzyme Inhib Med Chem , 37 :1752 , 2022 |
| Abstract : |
| PubMedSearch : Vieider_2022_J.Enzyme.Inhib.Med.Chem_37_1752 |
| PubMedID: 36124840 |
| Title : Quinazoline-4(3H)-one-7-carboxamide Derivatives as Human Soluble Epoxide Hydrolase Inhibitors with Developable 5-Lipoxygenase Activating Protein Inhibition - Turanli_2022_ACS.Omega_7_36354 |
| Author(s) : Turanli S , Ergul AG , Jordan PM , Olgac A , Caliskan B , Werz O , Banoglu E |
| Ref : ACS Omega , 7 :36354 , 2022 |
| Abstract : |
| PubMedSearch : Turanli_2022_ACS.Omega_7_36354 |
| PubMedID: 36278102 |
| Title : Discovery and Optimization of Indoline-Based Compounds as Dual 5-LOX\/sEH Inhibitors: In Vitro and In Vivo Anti-Inflammatory Characterization - Cerqua_2022_J.Med.Chem__ |
| Author(s) : Cerqua I , Musella S , Peltner LK , D'Avino D , Di Sarno V , Granato E , Vestuto V , Di Matteo R , Pace S , Ciaglia T , Bilancia R , Smaldone G , Di Matteo F , Di Micco S , Bifulco G , Pepe G , Basilicata MG , Rodriquez M , Gomez-Monterrey IM , Campiglia P , Ostacolo C , Roviezzo F , Werz O , Rossi A , Bertamino A |
| Ref : Journal of Medicinal Chemistry , : , 2022 |
| Abstract : |
| PubMedSearch : Cerqua_2022_J.Med.Chem__ |
| PubMedID: 36318728 |
| Title : Design of Dual Inhibitors of Soluble Epoxide Hydrolase and LTA4 Hydrolase - Hiesinger_2020_ACS.Med.Chem.Lett_11_298 |
| Author(s) : Hiesinger K , Schott A , Kramer JS , Blocher R , Witt F , Wittmann SK , Steinhilber D , Pogoryelov D , Gerstmeier J , Werz O , Proschak E |
| Ref : ACS Med Chem Lett , 11 :298 , 2020 |
| Abstract : |
| PubMedSearch : Hiesinger_2020_ACS.Med.Chem.Lett_11_298 |
| PubMedID: 32184960 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Synthesis, Biological Evaluation and Structure-Activity Relationships of Diflapolin Analogues as Dual sEH\/FLAP Inhibitors - Vieider_2019_ACS.Med.Chem.Lett_10_62 |
| Author(s) : Vieider L , Romp E , Temml V , Fischer J , Kretzer C , Schoenthaler M , Taha A , Hernandez-Olmos V , Sturm S , Schuster D , Werz O , Garscha U , Matuszczak B |
| Ref : ACS Med Chem Lett , 10 :62 , 2019 |
| Abstract : |
| PubMedSearch : Vieider_2019_ACS.Med.Chem.Lett_10_62 |
| PubMedID: 30655948 |
| Title : Targeting de novo lipogenesis as a novel approach in anti-cancer therapy - Stoiber_2018_Br.J.Cancer_118_43 |
| Author(s) : Stoiber K , Naglo O , Pernpeintner C , Zhang S , Koeberle A , Ulrich M , Werz O , Muller R , Zahler S , Lohmuller T , Feldmann J , Braig S |
| Ref : Br J Cancer , 118 :43 , 2018 |
| Abstract : |
| PubMedSearch : Stoiber_2018_Br.J.Cancer_118_43 |
| PubMedID: 29112683 |
| Title : Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening - Temml_2017_Sci.Rep_7_42751 |
| Author(s) : Temml V , Garscha U , Romp E , Schubert G , Gerstmeier J , Kutil Z , Matuszczak B , Waltenberger B , Stuppner H , Werz O , Schuster D |
| Ref : Sci Rep , 7 :42751 , 2017 |
| Abstract : |
| PubMedSearch : Temml_2017_Sci.Rep_7_42751 |
| PubMedID: 28218273 |
| Title : Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase - Garscha_2017_Sci.Rep_7_9398 |
| Author(s) : Garscha U , Romp E , Pace S , Rossi A , Temml V , Schuster D , Konig S , Gerstmeier J , Liening S , Werner M , Atze H , Wittmann S , Weinigel C , Rummler S , Scriba GK , Sautebin L , Werz O |
| Ref : Sci Rep , 7 :9398 , 2017 |
| Abstract : |
| PubMedSearch : Garscha_2017_Sci.Rep_7_9398 |
| PubMedID: 28839250 |