HY-155961
IC50 36 nM human-dpp4
General
Type : Thiazolidine, Sulfur Compound, Pyrazole, Pyrrolidine
Chemical_Nomenclature : 3,4,5-trihydroxy-N-[4-[(Z)-[3-[2-(2-methylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)-2-oxoethyl]-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl]phenyl]benzamide
Canonical SMILES : CS(=O)(=O)N1C=C2CN(CC2=N1)C(=O)CN3C(=O)\/C(=C\/C4=CC=C(C=C4)NC(=O)C5=CC(=C(C(=C5)O)O)O)\/SC3=O
InChI : InChI=1S\/C25H21N5O9S2\/c1-41(38,39)30-10-15-9-28(11-17(15)27-30)21(33)12-29-24(36)20(40-25(29)37)6-13-2-4-16(5-3-13)26-23(35)14-7-18(31)22(34)19(32)8-14\/h2-8,10,31-32,34H,9,11-12H2,1H3,(H,26,35)\/b20-6-
InChIKey : FCVWRMOTYDEKQU-IOXNKQMXSA-N
Other name(s) : Antidiabetic agent 2 || CS-0890616
MW : 599.6
Formula : C25H21N5O9S2
CAS_number :
PubChem : 168510439
UniChem : FCVWRMOTYDEKQU-IOXNKQMXSA-N
Target
Families : HY-155961 ligand of proteins in family
DPP4N_Peptidase_S9
Protein :
human-DPP4
References (1)
| Title : SAR and lead optimization of (Z)-5-(4-hydroxy-3-methoxybenzylidene)-3-(2-morpholinoacetyl)thiazolidine-2,4-dione as a potential multi-target antidiabetic agent - Shah_2023_Eur.J.Med.Chem_258_115591 |
| Author(s) : Shah M , Jan MS , Sadiq A , Khan S , Rashid U |
| Ref : Eur Journal of Medicinal Chemistry , 258 :115591 , 2023 |
| Abstract : |
| PubMedSearch : Shah_2023_Eur.J.Med.Chem_258_115591 |
| PubMedID: 37393789 |