HaloPROTAC3
General
Type : HaloTag-ligand, PROTAC, Sulfur Compound, Thiazole, Pyrrolidine, Organochlorine
Chemical_Nomenclature : (2S,4R)-N-[[2-[2-[2-[2-(6-chlorohexoxy)ethoxy]ethoxy]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-hydroxy-1-[(2S)-3-methyl-2-(3-oxo-1H-isoindol-2-yl)butanoyl]pyrrolidine-2-carboxamide
Canonical SMILES : CC1=C(SC=N1)C2=CC(=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)C)N4CC5=CC=CC=C5C4=O)O)OCCOCCOCCOCCCCCCCl
InChI : InChI=1S\/C41H55ClN4O8S\/c1-28(2)37(46-25-32-10-6-7-11-34(32)40(46)49)41(50)45-26-33(47)23-35(45)39(48)43-24-31-13-12-30(38-29(3)44-27-55-38)22-36(31)54-21-20-53-19-18-52-17-16-51-15-9-5-4-8-14-42\/h6-7,10-13,22,27-28,33,35,37,47H,4-5,8-9,14-21,23-26H2,1-3H3,(H,43,48)\/t33-,35+,37+\/m1\/s1
InChIKey : UABTZMQNIWDHGQ-JGNAJVFASA-N
Other name(s) : VH285-PEG4-C4-Cl || CHEMBL5269969
MW : 799.4
Formula : C41H55ClN4O8S
CAS_number : 1799506-07-2
PubChem : 156597126
UniChem : UABTZMQNIWDHGQ-JGNAJVFASA-N
Target
Families : HaloPROTAC3 ligand of proteins in family
Haloalkane_dehalogenase-HLD2
Protein :
rhoso-halo1
References (3)
| Title : HaloPROTAC3 treatment activates the unfolded protein response of the endoplasmic reticulum in non-engineered mammalian cell lines - Anisimova_2025_Mol.Biol.Cell__mbcE24080342 |
| Author(s) : Anisimova AS , Karagoz GE |
| Ref : Mol Biology of the cell , :mbcE24080342 , 2025 |
| Abstract : |
| PubMedSearch : Anisimova_2025_Mol.Biol.Cell__mbcE24080342 |
| PubMedID: 40105918 |
| Gene_locus related to this paper: rhoso-halo1 |
| Title : HaloPROTAC3 treatment activates the unfolded protein response of the endoplasmic reticulum in non-engineered mammalian cell lines - Anisimova_2025_Mol.Biol.Cell__mbcE24080342 |
| Author(s) : Anisimova AS , Karagoz GE |
| Ref : Mol Biology of the cell , :mbcE24080342 , 2025 |
| Abstract : |
| PubMedSearch : Anisimova_2025_Mol.Biol.Cell__mbcE24080342 |
| PubMedID: 40105918 |
| Gene_locus related to this paper: rhoso-halo1 |
| Title : HaloPROTAC3 treatment activates the unfolded protein response of the endoplasmic reticulum in non-engineered mammalian cell lines - Anisimova_2025_Mol.Biol.Cell__mbcE24080342 |
| Author(s) : Anisimova AS , Karagoz GE |
| Ref : Mol Biology of the cell , :mbcE24080342 , 2025 |
| Abstract : |
| PubMedSearch : Anisimova_2025_Mol.Biol.Cell__mbcE24080342 |
| PubMedID: 40105918 |
| Gene_locus related to this paper: rhoso-halo1 |