1. Home
  2. Type Inhibitor
  3. PROTAC

PROTAC

General

Proteolysis-targeting chimeras (PROTACs). PROTACs are bifunctional molecules consisting of a ligand targeting a protein of interest, a ligand recruiting an E3 ligase, and a connecting linker. The compound targets the protein toward degradation
Inhibitor Main targeted enzyme families Type Structure
t-TUCB-PROTAC-P3 Epoxide_hydrolase Urea derivative Multitarget FAAH inhibitor Triazol Trifluoro Piperidine Indole Isoindole PROTAC
t-TUCB-PROTAC-P4 Epoxide_hydrolase Urea derivative Triazol Trifluoro Piperidine Indole Piperazine Multitarget Isoindole FAAH inhibitor PROTAC
HaloPROTAC3 Haloalkane_dehalogenase-HLD2 HaloTag-ligand PROTAC Sulfur Compound Thiazole Pyrrolidine Organochlorine
JN-PROTAC Monoglyceridelipase_lysophospholip PROTAC Piperidine Benzodioxo Multitarget pNP Organochlorine
PROTAC-FL412 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Multitarget Piperidine Isoindole Indole
PROTAC-JSF67 Epoxide_hydrolase PROTAC Multitarget Trifluoro Piperidine Indole Isoindole Triazol Sulfur Compound Sulfonamide Carboxamide
PROTAC-JSF234 Epoxide_hydrolase PROTAC Multitarget Sulfur Compound Sulfonamide Trifluoro Indole Carboxamide
t-TUCB-PROTAC-Cpd8 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Multitarget Piperazine
ALT-PG2 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Piperidine Indole Isoindole Multitarget
t-TUCB-PROTAC-P3 Epoxide_hydrolase Urea derivative Multitarget FAAH inhibitor Triazol Trifluoro Piperidine Indole Isoindole PROTAC
t-TUCB-PROTAC-P4 Epoxide_hydrolase Urea derivative Triazol Trifluoro Piperidine Indole Piperazine Multitarget Isoindole FAAH inhibitor PROTAC
HaloPROTAC3 Haloalkane_dehalogenase-HLD2 HaloTag-ligand PROTAC Sulfur compound Thiazole Pyrrolidine Organochlorine
JN-PROTAC Monoglyceridelipase_lysophospholip PROTAC Piperidine Benzodioxo Multitarget pNP Organochlorine
PROTAC-FL412 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Multitarget Piperidine Isoindole Indole
PROTAC-JSF67 Epoxide_hydrolase PROTAC Multitarget Trifluoro Piperidine Indole Isoindole Triazol Sulfur compound Sulfonamide Carboxamide
PROTAC-JSF234 Epoxide_hydrolase PROTAC Multitarget Sulfur compound Sulfonamide Trifluoro Indole Carboxamide
t-TUCB-PROTAC-Cpd8 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Multitarget Piperazine
ALT-PG2 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Piperidine Indole Isoindole Multitarget
t-TUCB-PROTAC-P3 Epoxide_hydrolase Urea derivative Multitarget FAAH inhibitor Triazol Trifluoro Piperidine Indole Isoindole PROTAC
t-TUCB-PROTAC-P4 Epoxide_hydrolase Urea derivative Triazol Trifluoro Piperidine Indole Piperazine Multitarget Isoindole FAAH inhibitor PROTAC
HaloPROTAC3 Haloalkane_dehalogenase-HLD2 HaloTag-ligand PROTAC Sulfur compound Thiazole Pyrrolidine Organochlorine
JN-PROTAC Monoglyceridelipase_lysophospholip PROTAC Piperidine Benzodioxo Multitarget pNP Organochlorine
PROTAC-FL412 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Multitarget Piperidine Isoindole Indole
PROTAC-JSF67 Epoxide_hydrolase PROTAC Multitarget Trifluoro Piperidine Indole Isoindole Triazol Sulfur compound Sulfonamide Carboxamide
PROTAC-JSF234 Epoxide_hydrolase PROTAC Multitarget Sulfur compound Sulfonamide Trifluoro Indole Carboxamide
t-TUCB-PROTAC-Cpd8 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Multitarget Piperazine
ALT-PG2 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Piperidine Indole Isoindole Multitarget