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PROTAC

General

Proteolysis-targeting chimeras (PROTACs). PROTACs are bifunctional molecules consisting of a ligand targeting a protein of interest, a ligand recruiting an E3 ligase, and a connecting linker. The compound targets the protein toward degradation
Inhibitor Main targeted enzyme families Type Structure
PROTAC-FL412 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Multitarget Piperidine Indol
PROTAC-JSF67 Epoxide_hydrolase PROTAC Multitarget Trifluoro Piperidine Indol Triazol Sulfur Compound Sulfonamide Carboxamide
PROTAC-JSF234 Epoxide_hydrolase PROTAC Multitarget Sulfur Compound Sulfonamide Trifluoro Indol Carboxamide
t-TUCB-PROTAC-Cpd8 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Multitarget Piperazine
ALT-PG2 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Piperidine Indol Multitarget