Hydrazide-Hydrazone-Cpd12
Carbonic anhydrase isoenzymes I and II AChE and BChE, with IC50 values of 42.75 +/- 0.81 23.45 +/- 0.41 21.45 +/- 0.38 18.42 +/- 0.36 nM respectively
General
Type : Carbonic anhydrase inhibitor, Multitarget, Derivative of Nicotine, Benzoate, Naphthalen
Chemical_Nomenclature : 1-((2-Nicotinoylhydrazono)methyl)naphthalen-2-yl 4-(Dimethylamino)benzoate
Canonical SMILES : N1=CC=CC(=C1)C(NN=CC2=C4C(=CC=C2OC(=O)C3=CC=C(C=C3)N(C)C)C=CC=C4)=O
InChI : 1S\/C26H22N4O3\/c1-30(2)21-12-9-19(10-13-21)26(32)33-24-14-11-18-6-3-4-8-22(18)23(24)17-28-29-25(31)20-7-5-15-27-16-20\/h3-17H,1-2H3,(H,29,31)
InChIKey : KEOOXIGLSOTSCF-UHFFFAOYSA-N
Other name(s) : Compound 12
Target
References (1)
| Title : Synthesis of Novel Hydrazide-Hydrazone Compounds and In Vitro and In Silico Investigation of Their Biological Activities against AChE, BChE, and hCA I and II - Cakmak_2024_ACS.Omega_9_20030 |
| Author(s) : Cakmak R , Basaran E , Sahin K , Senturk M , Durdagi S |
| Ref : ACS Omega , 9 :20030 , 2024 |
| Abstract : |
| PubMedSearch : Cakmak_2024_ACS.Omega_9_20030 |
| PubMedID: 38737075 |