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Derivative of Nicotine

General

Nicotine is an alkaloid that is naturally produced in tobacco. Nicotine acts as a receptor agonist at most nicotinic acetylcholine receptors (nAChRs). not alpha/beta hydrolase target but used as building block for multitarget compounds
Inhibitor Main targeted enzyme families Type Structure
Hydrazide-Hydrazone-Cpd12 ACHE BCHE Carbonic anhydrase inhibitor Multitarget Derivative of Nicotine Benzoate Naphthalen
Cotinine Pectinacetylesterase-Notum Derivative of Nicotine Pyrrolidine Natural Alkaloid Drug Nicotinic agonist Not A\/B H target
Tacrine-nicotinamide ACHE Derivative of Tacrine Derivative of Nicotine Alkyl linked bis-ligand Nicotinamide Carboxamide
Nicotine ACHE BCHE Pectinacetylesterase-Notum Derivative of Nicotine Pyrrolidine Natural Alkaloid Drug Nicotinic agonist Not A\/B H target