JM-20
GABAergic receptor. Neuroprotective ability, anti-excitotoxic, anti-inflammatory, anti-apoptotic, mitoprotective and antioxidant effects. JM-20 inhibited all tested AChE but not BChE. The IC50 values were 123 nM +/- 0.2 (EeAChE), 158 nM +/- 0.1 (ghost HsAChE), and 172 nM +/- 0.2 (erythrocytic HsAChE)
General
Type : Benzodiazepin, Not A\/B H target, Pyridine, Multitarget, 2-nitrophenyl, Azepane
Chemical_Nomenclature : ethyl 2-methyl-4-(2-nitrophenyl)-4,11-dihydro-1H-pyrido[2,3-b][1,5]benzodiazepine-3-carboxylate
Canonical SMILES : CCOC(=O)C1=C(NC2=C(C1C3=CC=CC=C3[N+](=O)[O-])C=NC4=CC=CC=C4N2)C
InChI : InChI=1S\/C22H20N4O4\/c1-3-30-22(27)19-13(2)24-21-15(12-23-16-9-5-6-10-17(16)25-21)20(19)14-8-4-7-11-18(14)26(28)29\/h4-12,20,24-25H,3H2,1-2H3
InChIKey : SJSJDWHYJXEJSQ-UHFFFAOYSA-N
Other name(s) : SCHEMBL16089112 || 3-ethoxycarbonyl-2-methyl-4-(2-nitrophenyl)-4,11-dihydro-1h-pyrido[2,3-b][1,5]benzodiazepine
MW : 404.4
Formula : C22H20N4O4
CAS_number :
PubChem : 90451879
UniChem : SJSJDWHYJXEJSQ-UHFFFAOYSA-N
Target
Families : JM-20 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (3)
| Title : JM-20 Treatment After Mild Traumatic Brain Injury Reduces Glial Cell Pro-inflammatory Signaling and Behavioral and Cognitive Deficits by Increasing Neurotrophin Expression - Furtado_2021_Mol.Neurobiol_58_4615 |
| Author(s) : Furtado ABV , Goncalves DF , Hartmann DD , Courtes AA , Cassol G , Nunez-Figueredo Y , Argolo DS , do Nascimento RP , Costa SL , da Silva VDA , Royes LFF , Soares FAA |
| Ref : Molecular Neurobiology , 58 :4615 , 2021 |
| Abstract : |
| PubMedSearch : Furtado_2021_Mol.Neurobiol_58_4615 |
| PubMedID: 34148214 |
| Title : Molecular docking and in vitro evaluation of a new hybrid molecule (JM-20) on cholinesterase activity from different sources - D'Avila da Silva_2020_Biochimie_168_297 |
| Author(s) : D'Avila da Silva F , Nogara PA , Ochoa-Rodriguez E , Nunez-Figueredo Y , Wong-Guerra M , Rosemberg DB , Rocha J |
| Ref : Biochimie , 168 :297 , 2020 |
| Abstract : |
| PubMedSearch : D'Avila da Silva_2020_Biochimie_168_297 |
| PubMedID: 31770565 |
| Title : Anti-hypernociceptive and anti-inflammatory effects of JM-20: A novel hybrid neuroprotective compound - Garrido-Suarez_2020_Brain.Res.Bull_165_185 |
| Author(s) : Garrido-Suarez BB , Garrido G , Castro-Labrada M , Merino N , Valdes O , Pardo Z , Ochoa-Rodriguez E , Verdecia-Reyes Y , Delgado-Hernandez R , Godoy-Figueiredo J , Ferreira SH |
| Ref : Brain Research Bulletin , 165 :185 , 2020 |
| Abstract : |
| PubMedSearch : Garrido-Suarez_2020_Brain.Res.Bull_165_185 |
| PubMedID: 33096198 |