JN-PROTAC
Derivative of JZL184 with the MDM2 inhibitor Nutlin-3 analog. JN-PROTAC effectively induced MAGL targeted degradation and concomitantly enhanced P53 activation via MDM2 inhibition
General
Type : PROTAC, Piperidine, Benzodioxo, Multitarget, pNP
Chemical_Nomenclature :
Canonical SMILES : C1(=CC=C(C=C1)C(C2=CC=C3C(=C2)OCO3)(C4CCN(CC4)C(=O)OC5=CC=C(C=C5)[N+]([O-])=O)O)OCCOC(=O)CN6CCN(CC6=O)C(=O)N7C(=N[C@H]([C@H]7C8=CC=C(C=C8)Cl)C9=CC=C(C=C9)Cl)C\%10=C(C=C(C=C\%10)OC)OC(C)C
InChI : InChI=1S\/C60H58Cl2N6O14\/c1-37(2)81-51-33-48(76-3)21-22-49(51)57-63-55(38-4-11-43(61)12-5-38)56(39-6-13-44(62)14-7-39)67(57)58(71)66-29-28-65(53(69)34-66)35-54(70)78-31-30-77-46-17-8-40(9-18-46)60(73,42-10-23-50-52(32-42)80-36-79-50)41-24-26-64(27-25-41)59(72)82-47-19-15-45(16-20-47)68(74)75\/h4-23,32-33,37,41,55-56,73H,24-31,34-36H2,1-3H3\/t55-,56+,60?\/m0\/s1
InChIKey : KRVUYRMYSMFSLR-YLZSNNPHSA-N
Other name(s) :
Target
Families : JN-PROTAC ligand of proteins in family
Monoglyceridelipase_lysophospholip
Protein :
human-MGLL
References (1)
| Title : MAGL targeted PROTAC degrader simultaneously enhances P53 for synergistic treatment of glioblastoma stem cell - Yuan_2025_Cell.Death.Discov_11_109 |
| Author(s) : Yuan Z , Guo M , Zhang Y , Deng Y , Sun B , Hou Y , Wang X , Jin X , Liu Y , Shi B , Yin J |
| Ref : Cell Death Discov , 11 :109 , 2025 |
| Abstract : |
| PubMedSearch : Yuan_2025_Cell.Death.Discov_11_109 |
| PubMedID: 40113745 |
| Gene_locus related to this paper: human-MGLL |