pNP

General

Esters of 4-Nitrophenol (also called p-nitrophenol or 4-hydroxynitrobenzene) which is a phenolic compound that has a nitro group at the opposite position of the hydroxyl group on the benzene ring. Amounts of 4-nitrophenol produced by a particular enzyme in the presence of its corresponding substrate can be measured with a spectrophotometer at or around 405 nm and used as a proxy measurement for the amount of the enzyme activity in the sample.
Inhibitor Main targeted enzyme familyes Type Structure
H-Lys(4-nitro-Z)-pyrrolidide DPP4N_Peptidase_S9 Pyrrolidine Carbamate pNP Peptide
WWL153 PAF-Acetylhydrolase Piperazine Quinoline pNP
DOTA-(amide)4-(EG)n-tetraphosphonate Cutinase Polymer Poly-ethylene-glycol Organophosphate pNP
NCMP ACHE Chemical Warfare Agent Organophosphate Nerve Agent G-series Derivative of Sarin pNP
VXS BCHE ACHE PET probe Organophosphate Derivative of Paraoxon Derivative of VX pNP
Butoxyhexylphosphonate Hormone-sensitive_lipase_like Organophosphate pNP
B4-4NHP Hormone-sensitive_lipase_like Organophosphate pNP
M4-4NHP Hormone-sensitive_lipase_like Organophosphate pNP
MHH Hormone-sensitive_lipase_like Organophosphate pNP
Ru-NHC-1 Cutinase Organophosphate Pincer-Metal-cofactor pNP
Ru-NHC-3 Cutinase Organophosphate Pincer-Metal-cofactor pNP
Rh-pNP Canar_LipB Cutinase Organophosphate Pincer-Metal-cofactor pNP
ArM-Rhubidium-cofactor-8 Canar_LipB Cutinase Organophosphate Pincer-Metal-cofactor pNP
C12-myristoyl-MAG-like-phosphonate CarbLipBact_2 Organophosphate pNP Analogue of substrate Lipase inhibitor Azido
C14-palmitoyl-MAG-like-phosphonate CarbLipBact_2 Organophosphate pNP Lipase inhibitor Analogue of substrate Azido
C16-stearoyl-MAG-like-phosphonate CarbLipBact_2 Organophosphate Analogue of substrate Lipase inhibitor pNP Azido
C18-octadecyl-MAG-like-phosphonate Monoglyceridelipase_lysophospholip Organophosphate Analogue of substrate Lipase inhibitor pNP Azido
SXC Cutinase Organophosphate Pincer-Metal-cofactor pNP Sulfur Compound
5ALP-QYD Epoxide_hydrolase Carboxamide Sulfur Compound Thiomorpholine pNP Morpholine
PNPMPC ACPH_Peptidase_S9 pNP Carbamate
p-nitrophenyl-N-butyl-carbamate Cholesterol_esterase pNP Carbamate
p-nitrophenyl-N-butyl-N-methyl-carbamate Cholesterol_esterase pNP Carbamate
p-nitrophenyl-N-octyl-carbamate Cholesterol_esterase pNP Carbamate
PNPPC ACPH_Peptidase_S9 pNP Carbamate
JZL195 Monoglyceridelipase_lysophospholip Carb_B_Chordata ABHD6-Lip Piperazine FAAH inhibitor Multitarget pNP Phenoxyphenyl
JZL184 Monoglyceridelipase_lysophospholip Carb_B_Chordata ABHD6-Lip Piperidine Benzodioxo FAAH inhibitor Multitarget pNP
WWL222 AlphaBeta_hydrolase pNP Carbamate
WWL229 Carb_B_Chordata pNP Carbamate Piperidine
ABP-C6 Hormone-sensitive_lipase_like Monoglyceridelipase_lysophospholip ABHD11-Acetyl_transferase Carb_B_Chordata A85-EsteraseD-FGH LYsophospholipase_carboxylesterase PPase_methylesterase_euk ACPH_Peptidase_S9 CGI-58_ABHD5_ABHD4 Arylacetamide_deacetylase BCHE Prolylcarboxypeptidase DPP4N_Peptidase_S9 PC-sterol_acyltransferase pNP Organophosphate ABPP-Probe Azido
NBD-CP Organophosphate ABPP-Probe NBD-nitro-benzoxadiazol-fluorescent Benzoxadiazole pNP Phenanthrene
NBD-TG Hormone-sensitive_lipase_like Monoglyceridelipase_lysophospholip ABHD11-Acetyl_transferase Triacylglycerol NBD-nitro-benzoxadiazol-fluorescent ABPP-Probe pNP Benzoxadiazole
NBD-HE-HP Hormone-sensitive_lipase_like Carb_B_Chordata Monoglyceridelipase_lysophospholip A85-EsteraseD-FGH ABHD11-Acetyl_transferase LYsophospholipase_carboxylesterase PPase_methylesterase_euk ACPH_Peptidase_S9 CGI-58_ABHD5_ABHD4 Bacterial_lip_FamI.2 Lipase_3 Carb_B_Arthropoda Juvenile_hormone_esterase S9N_PPCE_Peptidase_S9 Organophosphate ABPP-Probe NBD-nitro-benzoxadiazol-fluorescent pNP Benzoxadiazole
BNPP Carb_B_Chordata Arylacetamide_deacetylase Organophosphate pNP
Nitrophenyl-methyl-p-biotinamidophenylmethylphosphonate BCHE Organophosphate pNP Sulfur Compound Biotin derivative
Armin ACHE Chemical Warfare Agent Organophosphate pNP
Chlorthion ACHE Insecticide Organophosphate pNP Sulfur Compound
Isochlorthion ACHE Insecticide Organophosphate pNP Sulfur Compound
Ethylchlorthion ACHE Insecticide Organophosphate Sulfur Compound pNP
EPN ACHE Insecticide Organophosphate Sulfur Compound Organothiophosphate pNP
EPN-oxon ACHE Insecticide Organophosphate pNP
Fenitrothion ACHE Organophosphate Sulfur Compound Organothiophosphate Insecticide pNP
IMP-pNP ACHE Cholesterol_esterase Organophosphate Surrogate OP Nerve Agent G-series pNP Derivative of Sarin
IMP-pNP-F ACHE Organophosphate Surrogate OP Nerve Agent G-series pNP Derivative of Sarin
NEMP-F ACHE Organophosphate Surrogate OP Nerve Agent V-series Derivative of VX pNP
NEMP ACHE Cholesterol_esterase Organophosphate Surrogate OP Nerve Agent V-series Derivative of VX pNP
NEDPA ACHE Cholesterol_esterase Organophosphate Surrogate OP Nerve Agent G-series pNP
Parathion-S ACHE Organophosphate Sulfur Compound Organothiophosphate pNP
Isoparathion ACHE Organophosphate Sulfur Compound Organothiophosphate pNP
Methylparaoxon ACHE Carboxypeptidase_S10 Insecticide Organophosphate Derivative of Paraoxon pNP
Methylparathion ACHE Insecticide Organophosphate Sulfur Compound Organothiophosphate Derivative of Paraoxon pNP
Paraoxon BCHE ACHE Cutinase Bacterial_lip_FamI.1 A85-EsteraseD-FGH Acetyl-esterase_deacetylase Hormone-sensitive_lipase_like PAF-Acetylhydrolase CarbLipBact_1 Pancreatic_lipase 5_AlphaBeta_hydrolase Bacterial_lip_FamI.3 Plant_carboxylesterase A85-Mycolyl-transferase Lipase_3 Lipase_2 Dienelactone_hydrolase Organophosphate Insecticide Derivative of Paraoxon pNP
l,2-Dioctylcarbamoylglycero-3-O-p-nitrophenyloctylphosphonate Cutinase Bacterial_lip_FamI.6 Organophosphate Analogue of substrate Lipase inhibitor Triacylglycerol pNP
di-O-octylglycero-O-(p-nitrophenyl)-n-hexyl-phosphonate Bacterial_lip_FamI.2 Lipase_3 Analogue of substrate Lipase inhibitor Triacylglycerol Organophosphate pNP
Parathion BCHE ACHE Insecticide Organophosphate Sulfur Compound Organothiophosphate pNP Derivative of Paraoxon