JP-2-1-7
General
Type : Pyrrolidine, Pyrazole, Pyridine, Carboxamide
Chemical_Nomenclature : 4-chloro-3-methyl-N-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1-(2-phenylethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide
Canonical SMILES : CC3=N[N](CCC1=CC=CC=C1)C4=NC=C(C(=O)NCC(=O)N2CCCC2)C(=C34)Cl
InChI : InChI=1S\/C22H24ClN5O2\/c1-15-19-20(23)17(22(30)25-14-18(29)27-10-5-6-11-27)13-24-21(19)28(26-15)12-9-16-7-3-2-4-8-16\/h2-4,7-8,13H,5-6,9-12,14H2,1H3,(H,25,30)
InChIKey : JYRCKPLREKYKRY-UHFFFAOYSA-N
Other name(s) : A1CQZ || A1CQU
Target
Families : JP-2-1-7 ligand of proteins in family
S9N_PPCE_Peptidase_S9
Structure :
9Q6K
Protein :
human-PREP
References (1)
| Title : Structure-Guided Optimization of 4-Chloro-Pyrazolopyridine Analogs for Covalent PREP Inhibition - Thakur_2026_J.Med.Chem__ |
| Author(s) : Thakur K , Fucci I , Pandian J , Suazo KF , Monteiro DCF , Yoo E |
| Ref : Journal of Medicinal Chemistry , : , 2026 |
| Abstract : |
| PubMedSearch : Thakur_2026_J.Med.Chem__ |
| PubMedID: 41512187 |
| Gene_locus related to this paper: human-PREPL |