JW912
JW912 selectively labels MAGL and ABHD6 at concentrations below 10 microM oss the proteome
General
Type : Carbamate, BODIPY-derivative, Boranuidatricyclo, Boron compound, Trifluoro, Near-Infrared fluorescent Probe, Fluorescent Probe
Chemical_Nomenclature : 5,5-difluoro-7-(3-((2-(1-(((1,1,1,3,3,3-hexafluoropropan-2-yl)oxy)carbonyl)piperidine-4-carboxamido)ethyl)amino)-3-oxopropyl)-1,3-dimethyl-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uide
Canonical SMILES : C23=CC1=CC=C([N]1[B-]([N+]2=C(C=C3C)C)(F)F)CCC(NCCNC(=O)C4CCN(CC4)C(=O)OC(C(F)(F)F)C(F)(F)F)=O
InChI : InChI=1S\/C26H30BF8N5O4\/c1-15-13-16(2)39-20(15)14-19-4-3-18(40(19)27(39,34)35)5-6-21(41)36-9-10-37-22(42)17-7-11-38(12-8-17)24(43)44-23(25(28,29)30)26(31,32)33\/h3-4,13-14,17,23H,5-12H2,1-2H3,(H,36,41)(H,37,42)
InChIKey : XDYYGPCTGNBTGF-UHFFFAOYSA-N
Other name(s) :
Target
References (6)
| Title : Monoacylglycerol lipase inhibitors: modulators for lipid metabolism in cancer malignancy, neurological and metabolic disorders - Deng_2020_Acta.Pharm.Sin.B_10_582 |
| Author(s) : Deng H , Li W |
| Ref : Acta Pharm Sin B , 10 :582 , 2020 |
| Abstract : |
| PubMedSearch : Deng_2020_Acta.Pharm.Sin.B_10_582 |
| PubMedID: 32322464 |
| Title : Monoacylglycerol lipase inhibitors: modulators for lipid metabolism in cancer malignancy, neurological and metabolic disorders - Deng_2020_Acta.Pharm.Sin.B_10_582 |
| Author(s) : Deng H , Li W |
| Ref : Acta Pharm Sin B , 10 :582 , 2020 |
| Abstract : |
| PubMedSearch : Deng_2020_Acta.Pharm.Sin.B_10_582 |
| PubMedID: 32322464 |
| Title : Monoacylglycerol lipase inhibitors: modulators for lipid metabolism in cancer malignancy, neurological and metabolic disorders - Deng_2020_Acta.Pharm.Sin.B_10_582 |
| Author(s) : Deng H , Li W |
| Ref : Acta Pharm Sin B , 10 :582 , 2020 |
| Abstract : |
| PubMedSearch : Deng_2020_Acta.Pharm.Sin.B_10_582 |
| PubMedID: 32322464 |
| Title : Proteome-wide reactivity profiling identifies diverse carbamate chemotypes tuned for serine hydrolase inhibition - Chang_2013_ACS.Chem.Biol_8_1590 |
| Author(s) : Chang JW , Cognetta AB, 3rd , Niphakis MJ , Cravatt BF |
| Ref : ACS Chemical Biology , 8 :1590 , 2013 |
| Abstract : |
| PubMedSearch : Chang_2013_ACS.Chem.Biol_8_1590 |
| PubMedID: 23701408 |
| Title : Proteome-wide reactivity profiling identifies diverse carbamate chemotypes tuned for serine hydrolase inhibition - Chang_2013_ACS.Chem.Biol_8_1590 |
| Author(s) : Chang JW , Cognetta AB, 3rd , Niphakis MJ , Cravatt BF |
| Ref : ACS Chemical Biology , 8 :1590 , 2013 |
| Abstract : |
| PubMedSearch : Chang_2013_ACS.Chem.Biol_8_1590 |
| PubMedID: 23701408 |
| Title : Proteome-wide reactivity profiling identifies diverse carbamate chemotypes tuned for serine hydrolase inhibition - Chang_2013_ACS.Chem.Biol_8_1590 |
| Author(s) : Chang JW , Cognetta AB, 3rd , Niphakis MJ , Cravatt BF |
| Ref : ACS Chemical Biology , 8 :1590 , 2013 |
| Abstract : |
| PubMedSearch : Chang_2013_ACS.Chem.Biol_8_1590 |
| PubMedID: 23701408 |