KT-2-126
General
Type : Pyrrolidine, Pyrazole, Pyridine, Carboxamide
Chemical_Nomenclature : 4-chloro-N-[3-oxo-3-(pyrrolidin-1-yl)propyl]-3-phenyl-1-(2-phenylethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide
Canonical SMILES : ClC2=C1C(=N[N](C1=NC=C2C(=O)NCCC(=O)N3CCCC3)CCC4=CC=CC=C4)C5=CC=CC=C5
InChI : InChI=1S\/C28H28ClN5O2\/c29-25-22(28(36)30-15-13-23(35)33-16-7-8-17-33)19-31-27-24(25)26(21-11-5-2-6-12-21)32-34(27)18-14-20-9-3-1-4-10-20\/h1-6,9-12,19H,7-8,13-18H2,(H,30,36)
InChIKey : DJVUDQJDGKLLLE-UHFFFAOYSA-N
Other name(s) : A1CQ0 || A1CQU
Target
Families : KT-2-126 ligand of proteins in family
S9N_PPCE_Peptidase_S9
Structure :
9Q6J
Protein :
human-PREP
References (2)
| Title : Structure-Guided Optimization of 4-Chloro-Pyrazolopyridine Analogs for Covalent PREP Inhibition - Thakur_2026_J.Med.Chem__ |
| Author(s) : Thakur K , Fucci I , Pandian J , Suazo KF , Monteiro DCF , Yoo E |
| Ref : Journal of Medicinal Chemistry , : , 2026 |
| Abstract : |
| PubMedSearch : Thakur_2026_J.Med.Chem__ |
| PubMedID: 41512187 |
| Gene_locus related to this paper: human-PREPL |
| Title : Structure-Guided Optimization of 4-Chloro-Pyrazolopyridine Analogs for Covalent PREP Inhibition - Thakur_2026_J.Med.Chem__ |
| Author(s) : Thakur K , Fucci I , Pandian J , Suazo KF , Monteiro DCF , Yoo E |
| Ref : Journal of Medicinal Chemistry , : , 2026 |
| Abstract : |
| PubMedSearch : Thakur_2026_J.Med.Chem__ |
| PubMedID: 41512187 |
| Gene_locus related to this paper: human-PREPL |