KT-2-186
General
Type : Pyrrolidine, Pyrazole, Pyridine, Carboxamide
Chemical_Nomenclature : 4-chloro-3-methyl-N-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1-[2-(pyridin-3-yl)ethyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxamide
Canonical SMILES : CC2=N[N](CCC1=CC=CN=C1)C3=C2C(=C(C=N3)C(=O)NCC(=O)N4CCCC4)Cl
InChI : InChI=1S\/C21H23ClN6O2\/c1-14-18-19(22)16(21(30)25-13-17(29)27-8-2-3-9-27)12-24-20(18)28(26-14)10-6-15-5-4-7-23-11-15\/h4-5,7,11-12H,2-3,6,8-10,13H2,1H3,(H,25,30)
InChIKey : WYZBSXHPELEZFB-UHFFFAOYSA-N
Other name(s) : A1CQ1 || A1CQU
Target
Families : KT-2-186 ligand of proteins in family
S9N_PPCE_Peptidase_S9
Structure :
9Q6X
Protein :
human-PREP
References (2)
| Title : Structure-Guided Optimization of 4-Chloro-Pyrazolopyridine Analogs for Covalent PREP Inhibition - Thakur_2026_J.Med.Chem__ |
| Author(s) : Thakur K , Fucci I , Pandian J , Suazo KF , Monteiro DCF , Yoo E |
| Ref : Journal of Medicinal Chemistry , : , 2026 |
| Abstract : |
| PubMedSearch : Thakur_2026_J.Med.Chem__ |
| PubMedID: 41512187 |
| Gene_locus related to this paper: human-PREPL |
| Title : Structure-Guided Optimization of 4-Chloro-Pyrazolopyridine Analogs for Covalent PREP Inhibition - Thakur_2026_J.Med.Chem__ |
| Author(s) : Thakur K , Fucci I , Pandian J , Suazo KF , Monteiro DCF , Yoo E |
| Ref : Journal of Medicinal Chemistry , : , 2026 |
| Abstract : |
| PubMedSearch : Thakur_2026_J.Med.Chem__ |
| PubMedID: 41512187 |
| Gene_locus related to this paper: human-PREPL |