KT-2-74
General
Type : Pyrrolidine, Pyrazole, Pyridine, Carboxamide
Chemical_Nomenclature : 4-chloro-1,3-dimethyl-N-(2-{[3-oxo-3-(pyrrolidin-1-yl)propyl](3-phenylpropyl)amino}ethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide
Canonical SMILES : C[N]1N=C(C)C2=C(Cl)C(=CN=C12)C(=O)NCCN(CCCC3=CC=CC=C3)CCC(=O)N4CCCC4
InChI : InChI=1S\/C27H35ClN6O2\/c1-20-24-25(28)22(19-30-26(24)32(2)31-20)27(36)29-13-18-33(14-8-11-21-9-4-3-5-10-21)17-12-23(35)34-15-6-7-16-34\/h3-5,9-10,19H,6-8,11-18H2,1-2H3,(H,29,36)
InChIKey : NWHPUFLAUFXDCP-UHFFFAOYSA-N
Other name(s) : A1CQT
Target
Families : KT-2-74 ligand of proteins in family
S9N_PPCE_Peptidase_S9
Protein :
human-PREP
References (2)
| Title : Structure-Guided Optimization of 4-Chloro-Pyrazolopyridine Analogs for Covalent PREP Inhibition - Thakur_2026_J.Med.Chem__ |
| Author(s) : Thakur K , Fucci I , Pandian J , Suazo KF , Monteiro DCF , Yoo E |
| Ref : Journal of Medicinal Chemistry , : , 2026 |
| Abstract : |
| PubMedSearch : Thakur_2026_J.Med.Chem__ |
| PubMedID: 41512187 |
| Gene_locus related to this paper: human-PREPL |
| Title : Structure-Guided Optimization of 4-Chloro-Pyrazolopyridine Analogs for Covalent PREP Inhibition - Thakur_2026_J.Med.Chem__ |
| Author(s) : Thakur K , Fucci I , Pandian J , Suazo KF , Monteiro DCF , Yoo E |
| Ref : Journal of Medicinal Chemistry , : , 2026 |
| Abstract : |
| PubMedSearch : Thakur_2026_J.Med.Chem__ |
| PubMedID: 41512187 |
| Gene_locus related to this paper: human-PREPL |