KT-2-75
General
Type : Pyrrolidine, Pyrazole, Pyridine, Carboxamide
Chemical_Nomenclature : 4-chloro-1,3-dimethyl-N-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxamide
Canonical SMILES : C[N]1N=C(C)C2=C1N=CC(=C2Cl)C(=O)NCCC(=O)N3CCCC3
InChI : InChI=1S\/C16H20ClN5O2\/c1-10-13-14(17)11(9-19-15(13)21(2)20-10)16(24)18-6-5-12(23)22-7-3-4-8-22\/h9H,3-8H2,1-2H3,(H,18,24)
InChIKey : ZZTUZSXNOWFVDG-UHFFFAOYSA-N
Other name(s) : A1CQU
Target
Families : KT-2-75 ligand of proteins in family
S9N_PPCE_Peptidase_S9
Structure :
9Q65
Protein :
human-PREP
References (2)
| Title : Structure-Guided Optimization of 4-Chloro-Pyrazolopyridine Analogs for Covalent PREP Inhibition - Thakur_2026_J.Med.Chem__ |
| Author(s) : Thakur K , Fucci I , Pandian J , Suazo KF , Monteiro DCF , Yoo E |
| Ref : Journal of Medicinal Chemistry , : , 2026 |
| Abstract : |
| PubMedSearch : Thakur_2026_J.Med.Chem__ |
| PubMedID: 41512187 |
| Gene_locus related to this paper: human-PREPL |
| Title : Structure-Guided Optimization of 4-Chloro-Pyrazolopyridine Analogs for Covalent PREP Inhibition - Thakur_2026_J.Med.Chem__ |
| Author(s) : Thakur K , Fucci I , Pandian J , Suazo KF , Monteiro DCF , Yoo E |
| Ref : Journal of Medicinal Chemistry , : , 2026 |
| Abstract : |
| PubMedSearch : Thakur_2026_J.Med.Chem__ |
| PubMedID: 41512187 |
| Gene_locus related to this paper: human-PREPL |