Lyplal1-IN-1
inhibitor of Lysophospholipase-like 1 (LYPLAL1) with an IC50 of 0.006 microM
General
Type : Piperidine, Urea derivative, Triazol, Morpholine, Pyrimidine
Chemical_Nomenclature : (2R,3R)-1-[3-[4-(2-morpholin-4-ylpyrimidin-5-yl)phenyl]-1,2,4-triazole-1-carbonyl]-2-phenylpiperidine-3-carboxylic acid
Canonical SMILES : C1C[C@H]([C@@H](N(C1)C(=O)N2C=NC(=N2)C3=CC=C(C=C3)C4=CN=C(N=C4)N5CCOCC5)C6=CC=CC=C6)C(=O)O
InChI : InChI=1S\/C29H29N7O4\/c37-27(38)24-7-4-12-35(25(24)21-5-2-1-3-6-21)29(39)36-19-32-26(33-36)22-10-8-20(9-11-22)23-17-30-28(31-18-23)34-13-15-40-16-14-34\/h1-3,5-6,8-11,17-19,24-25H,4,7,12-16H2,(H,37,38)\/t24-,25+\/m1\/s1
InChIKey : OWBNMAVVNDAXQY-RPBOFIJWSA-N
Other name(s) : CHEMBL4543373 || BDBM195580 || AKOS040741994 || PD128359 || HY-124700 || CS-0087355
MW : 539.6
Formula : C29H29N7O4
CAS_number : 1966129-74-7
PubChem : 122172795
UniChem : OWBNMAVVNDAXQY-RPBOFIJWSA-N
Target
Families : Lyplal1-IN-1 ligand of proteins in family
LYsophospholipase_carboxylesterase
Protein :
human-LYPLAL1
References (2)
| Title : Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the response to anti-tumor immunotherapy - Fan_2023_Mol.Cell_83_3520 |
| Author(s) : Fan Y , Gao Y , Nie L , Hou T , Dan W , Wang Z , Liu T , Wei Y , Wang Y , Liu B , Que T , Lei Y , Zeng J , Ma J , Wei W , Li L |
| Ref : Mol Cell , 83 :3520 , 2023 |
| Abstract : |
| PubMedSearch : Fan_2023_Mol.Cell_83_3520 |
| PubMedID: 37802025 |
| Gene_locus related to this paper: human-LYPLAL1 |
| Title : Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism - Ahn_2016_ACS.Chem.Biol_11_2529 |
| Author(s) : Ahn K , Boehm M , Brown MF , Calloway J , Che Y , Chen J , Fennell KF , Geoghegan KF , Gilbert AM , Gutierrez JA , Kalgutkar AS , Lanba A , Limberakis C , Magee TV , O'Doherty I , Oliver R , Pabst B , Pandit J , Parris K , Pfefferkorn JA , Rolph TP , Patel R , Schuff B , Shanmugasundaram V , Starr JT , Varghese AH , Vera NB , Vernochet C , Yan J |
| Ref : ACS Chemical Biology , 11 :2529 , 2016 |
| Abstract : |
| PubMedSearch : Ahn_2016_ACS.Chem.Biol_11_2529 |
| PubMedID: 27391855 |
| Gene_locus related to this paper: human-LYPLAL1 |