ML30
human MAGL [3H]-2-OG hydrolysis IC50 0.000540 microM ; p-nitrophenylpropionate as substrate Ki 0.075700 microM
General
Type : Piperazine, Triazol, FAAH inhibitor, Urea derivative
Chemical_Nomenclature : (4-benzhydrylpiperazin-1-yl)-(benzotriazol-1-yl)methanone
Canonical SMILES : C1CN(CCN1C(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)N4C5=CC=CC=C5N=N4
InChI : InChI=1S\/C24H23N5O\/c30-24(29-22-14-8-7-13-21(22)25-26-29)28-17-15-27(16-18-28)23(19-9-3-1-4-10-19)20-11-5-2-6-12-20\/h1-14,23H,15-18H2
InChIKey : XOZPAZLUHXWSDR-UHFFFAOYSA-N
Other name(s) : CHEMBL2159781 || ml30 || GLXC-02032 || BDBM50394369 || (4-Benzhydryl-piperazin-1-yl)-benzotriazol-1-yl-methanone
MW : 397.5
Formula : C24H23N5O
CAS_number : 1403353-52-5
PubChem : 71453311
UniChem : XOZPAZLUHXWSDR-UHFFFAOYSA-N
Target
Families : ML30 ligand of proteins in family
Monoglyceridelipase_lysophospholip
Protein :
human-MGLL
References (1)
| Title : Development and characterization of endocannabinoid hydrolases FAAH and MAGL inhibitors bearing a benzotriazol-1-yl carboxamide scaffold - Morera_2012_Bioorg.Med.Chem_20_6260 |
| Author(s) : Morera L , Labar G , Ortar G , Lambert DM |
| Ref : Bioorganic & Medicinal Chemistry , 20 :6260 , 2012 |
| Abstract : |
| PubMedSearch : Morera_2012_Bioorg.Med.Chem_20_6260 |
| PubMedID: 23036333 |