Memagal
balanced inhibiting profile against the acetylcholinesterase enzyme (galantamine) and the NMDA receptor (memantine): rAChE IC50 =1.16 nM; NMDAR Ki 4.60 muM
General
Type : Multitarget, Derivative of Galanthamine, NMDA-Ligand, Alkyl linked bis-ligand, Benzazepin, Azepane
Chemical_Nomenclature : (1S,12S,14R)-4-[6-[(3,5-dimethyl-1-adamantyl)amino]hexyl]-9-methoxy-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-ol
Canonical SMILES : CC12CC3CC(C1)(CC(C3)(C2)NCCCCCCN4CCC56C=CC(CC5OC7=C(C=CC(=C67)C4)OC)O)C
InChI : InChI=1S\/C34H50N2O3\/c1-31-17-24-18-32(2,21-31)23-33(19-24,22-31)35-13-6-4-5-7-14-36-15-12-34-11-10-26(37)16-28(34)39-30-27(38-3)9-8-25(20-36)29(30)34\/h8-11,24,26,28,35,37H,4-7,12-23H2,1-3H3\/t24?,26-,28-,31?,32?,33?,34-\/m0\/s1
InChIKey : LUJPPSLEDAYBGR-WDOOIYNRSA-N
Other name(s) : CHEMBL2178784 || BDBM50398928
MW : 534.8
Formula : C34H50N2O3
CAS_number :
PubChem : 71450067
UniChem : LUJPPSLEDAYBGR-WDOOIYNRSA-N
Target
Families : Memagal ligand of proteins in family
ACHE
References (1)
| Title : Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease - Simoni_2012_J.Med.Chem_55_9708 |
| Author(s) : Simoni E , Daniele S , Bottegoni G , Pizzirani D , Trincavelli ML , Goldoni L , Tarozzo G , Reggiani A , Martini C , Piomelli D , Melchiorre C , Rosini M , Cavalli A |
| Ref : Journal of Medicinal Chemistry , 55 :9708 , 2012 |
| Abstract : |
| PubMedSearch : Simoni_2012_J.Med.Chem_55_9708 |
| PubMedID: 23033965 |