NMDA-Ligand

General

The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel found in neurons. Not an alpha/beta hydrolase target but can be used as a building block for larger inhibitors of enzymes of the family designed as multitarget compounds. NMDA receptor: ionotropic clas of glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner.
Inhibitor Main targeted enzyme families Type Structure
7-Methyloxyde-PhO-cpd-I52 ACHE BCHE Multitarget NMDA-Ligand Derivative of Tacrine
7-PhO-THA ACHE BCHE Multitarget NMDA-Ligand Derivative of Tacrine
Amiridine-Admantyl-5d BCHE Quinoline Derivative of Tacrine Derivative of Amiridine Adamantyl NMDA-Ligand Multitarget
Memagal ACHE Multitarget Derivative of Galanthamine NMDA-Ligand Alkyl linked bis-ligand Benzazepin Azepane
Carbacrine BCHE ACHE Alkyl linked bis-ligand Multitarget Carbazol Derivative of Tacrine NMDA-Ligand
ARN14140-doubleboundlink ACHE Adamantyl Alkyl linked bis-ligand Multitarget Derivative of Galanthamine NMDA-Ligand Azepane
ARN14140 ACHE Adamantyl Multitarget Derivative of Galanthamine NMDA-Ligand Alkyl linked bis-ligand
benzohomoadamantane-chlorotacrine-18a ACHE Multitarget NMDA-Ligand Adamantyl Derivative of Tacrine
benzohomoadamantane-chlorotacrine-18b BCHE ACHE Multitarget NMDA-Ligand Adamantyl Derivative of Tacrine Alkyl linked bis-ligand
triazole-aryl-adamantane-Cpd32 ACHE Multitarget NMDA-Ligand Adamantyl Triazol
7-methoxytacrine-memantine-Cpd4 ACHE Multitarget NMDA-Ligand Adamantyl Urea derivative Alkyl linked bis-ligand Sulfur Compound Derivative of Tacrine
NMDA-BCHE-C-2h BCHE Multitarget NMDA-Ligand Carbazol Adamantyl
NMDA-BCHE-4a BCHE Multitarget NMDA-Ligand Carbazol Adamantyl
Gamma-carboline-phenothiazine-Cpd7b BCHE beta-carboline Phenothiazine Indole NMDA-Ligand Multitarget
Gamma-carboline-nonyl-bivalent BCHE ACHE beta-carboline Indole NMDA-Ligand Multitarget Alkyl linked bis-ligand