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NMDA-Ligand

General

The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel found in neurons. Not an alpha/beta hydrolase target but can be used as a building block for larger inhibitors of enzymes of the family designed as multitarget compounds. NMDA receptor: ionotropic clas of glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. Used as building blocks of Multi-target drug ligand MTDL
Inhibitor Main targeted enzyme families Type Structure
Methylthiophen-tacrine-Amine-cpd5m ACHE BCHE Multitarget NMDA-Ligand Derivative of Tacrine Acridine Sulfur Compound Thiophen
7-Methyloxyde-PhO-cpd-II52 ACHE BCHE Multitarget NMDA-Ligand Derivative of Tacrine Acridine
7-Methyloxyde-PhO-cpd-I52 ACHE BCHE Multitarget NMDA-Ligand Derivative of Tacrine
7-PhO-THA ACHE BCHE Multitarget NMDA-Ligand Derivative of Tacrine Acridine
Amiridine-Adamantyl-5d BCHE Quinoline Derivative of Tacrine Derivative of Amiridine Adamantyl NMDA-Ligand Multitarget Naphthalen
Memagal ACHE Multitarget Derivative of Galanthamine NMDA-Ligand Alkyl linked bis-ligand Benzazepin Azepane
Carbacrine BCHE ACHE Alkyl linked bis-ligand Multitarget Carbazol beta-carboline Derivative of Tacrine Acridine NMDA-Ligand Organochlorine
ARN14140-doubleboundlink ACHE Adamantyl Alkyl linked bis-ligand Multitarget Derivative of Galanthamine NMDA-Ligand Benzazepin Azepane
ARN14140 ACHE Adamantyl Multitarget Derivative of Galanthamine NMDA-Ligand Alkyl linked bis-ligand Benzazepin Azepane
benzohomoadamantane-chlorotacrine-18a ACHE Multitarget NMDA-Ligand Adamantyl Derivative of Tacrine Acridine
benzohomoadamantane-chlorotacrine-18b BCHE ACHE Multitarget NMDA-Ligand Adamantyl Derivative of Tacrine Acridine Alkyl linked bis-ligand
triazole-aryl-adamantane-Cpd32 ACHE Multitarget NMDA-Ligand Adamantyl Triazol
7-methoxytacrine-memantine-Cpd4 ACHE Multitarget NMDA-Ligand Adamantyl Urea derivative Alkyl linked bis-ligand Sulfur Compound Derivative of Tacrine Acridine
NMDA-BCHE-C-2h BCHE Multitarget NMDA-Ligand Carbazol beta-carboline Adamantyl
NMDA-BCHE-4a BCHE Multitarget NMDA-Ligand Carbazol Adamantyl
Gamma-carboline-phenothiazine-Cpd7b BCHE beta-carboline Phenothiazine Indole NMDA-Ligand Multitarget
Gamma-carboline-nonyl-bivalent BCHE ACHE beta-carboline Indole NMDA-Ligand Multitarget Alkyl linked bis-ligand