Methoxybenzoxazol-tacrine-cpd44
General
Type : Benzoxazol, Derivative of Tacrine, Acridine, Multitarget, GSK-3 kinase inhibitor, anti-Abeta-aggregation
Chemical_Nomenclature : N1-(7-methoxybenzo[d]oxazol-6-yl)-N3-(1,2,3,4-tetrahydroacridin-9-yl) propane-1,3-diamine
Canonical SMILES : C1CC2=C(CC1)C(=C3C(=N2)C=CC=C3)NCCCNC4=CC=C5C(=C4OC)OC=N5
InChI : InChI=1S\/C24H26N4O2\/c1-29-23-20(11-12-21-24(23)30-15-27-21)25-13-6-14-26-22-16-7-2-4-9-18(16)28-19-10-5-3-8-17(19)22\/h2,4,7,9,11-12,15,25H,3,5-6,8,10,13-14H2,1H3,(H,26,28)
InChIKey : PMCDTVBRDLMIDB-UHFFFAOYSA-N
Other name(s) : Compound 44
Target
Families : Methoxybenzoxazol-tacrine-cpd44 ligand of proteins in family
ACHE
References (1)
| Title : Triple-Target Inhibition of Cholinesterase, Amyloid Aggregation, and GSK3beta to Ameliorate Cognitive Deficits and Neuropathology in the Triple-Transgenic Mouse Model of Alzheimer's Disease - He_2025_Neurosci.Bull__ |
| Author(s) : He J , Sun S , Wang H , Ying Z , Tam KY |
| Ref : Neurosci Bull , : , 2025 |
| Abstract : |
| PubMedSearch : He_2025_Neurosci.Bull__ |
| PubMedID: 39907971 |