N-saccharinopentyl-chlorobenzylamino-cpd42
EeAChE IC50 = 70 nM
General
Type : Alkyl linked bis-ligand, Sulfur Compound, Derivative of Saccharin, Organochlorine
Chemical_Nomenclature : 2-(5-(3-chlorobenzylamino)pentyl)benzo[d]isothiazol-3(2H)-one 1,1-dioxide
Canonical SMILES : C12=C(C=CC=C1)[S](N(C2=O)CCCCCNCC3=CC=CC(=C3)Cl)(=O)=O
InChI : InChI=1S\/C19H21ClN2O3S\/c20-16-8-6-7-15(13-16)14-21-11-4-1-5-12-22-19(23)17-9-2-3-10-18(17)26(22,24)25\/h2-3,6-10,13,21H,1,4-5,11-12,14H2
InChIKey : QZBHSCWBOIJDRO-UHFFFAOYSA-N
Other name(s) : Compound 42
Target
Families : N-saccharinopentyl-chlorobenzylamino-cpd42 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (3)
| Title : Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta - Hebda_2016_Molecules_21_410 |
| Author(s) : Hebda M , Bajda M , Wieckowska A , Szalaj N , Pasieka A , Panek D , Godyn J , Wichur T , Knez D , Gobec S , Malawska B |
| Ref : Molecules , 21 :410 , 2016 |
| Abstract : |
| PubMedSearch : Hebda_2016_Molecules_21_410 |
| PubMedID: 27023510 |
| Title : Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta - Hebda_2016_Molecules_21_410 |
| Author(s) : Hebda M , Bajda M , Wieckowska A , Szalaj N , Pasieka A , Panek D , Godyn J , Wichur T , Knez D , Gobec S , Malawska B |
| Ref : Molecules , 21 :410 , 2016 |
| Abstract : |
| PubMedSearch : Hebda_2016_Molecules_21_410 |
| PubMedID: 27023510 |
| Title : Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta - Hebda_2016_Molecules_21_410 |
| Author(s) : Hebda M , Bajda M , Wieckowska A , Szalaj N , Pasieka A , Panek D , Godyn J , Wichur T , Knez D , Gobec S , Malawska B |
| Ref : Molecules , 21 :410 , 2016 |
| Abstract : |
| PubMedSearch : Hebda_2016_Molecules_21_410 |
| PubMedID: 27023510 |