Full name : Gobec Stanislav
First name : Stanislav
Mail : Faculty of Pharmacy, University of Ljubljana , Askerceva 7, 1000 Ljubljana
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Country : Slovenia
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Comment
| Title : Synthesis and biochemical evaluation of new 3-amido-4-substituted monocyclic -lactams as inhibitors of penicillin-binding protein(s) - Grabrijan_2024_Acta.Pharm_74_423 |
| Author(s) : Grabrijan K , Benedik NS , Krajnc A , Bozovicar K , Knez D , Proj M , Zdovc I , Sosic I , Contreras-Martel C , Dessen A , Rambaher MH , Gobec S |
| Ref : Acta Pharm , 74 :423 , 2024 |
| Abstract : |
| PubMedSearch : Grabrijan_2024_Acta.Pharm_74_423 |
| PubMedID: 39279527 |
| Title : Dual inhibition of butyrylcholinesterase and p38alpha mitogen-activated protein kinase: A new approach for the treatment of Alzheimer's disease - Benetik_2024_Pharmacol.Ther__108748 |
| Author(s) : Benetik SF , Knez D , Obreza A , Kosak U , Gobec S |
| Ref : Pharmacol Ther , :108748 , 2024 |
| Abstract : |
| PubMedSearch : Benetik_2024_Pharmacol.Ther__108748 |
| PubMedID: 39521443 |
| Title : Development of novel aza-stilbenes as a new class of selective MAO-B inhibitors for the treatment of Parkinson's disease - Knez_2024_Bioorg.Chem_153_107877 |
| Author(s) : Knez D , Wang F , Duan WX , Hrast Rambaher M , Gobec S , Cheng XY , Wang XB , Mao CJ , Liu CF , Frlan R |
| Ref : Bioorg Chem , 153 :107877 , 2024 |
| Abstract : |
| PubMedSearch : Knez_2024_Bioorg.Chem_153_107877 |
| PubMedID: 39396452 |
| Title : Biological Evaluation of Valeriana Extracts from Argentina with Potent Cholinesterase Inhibition for the Treatment of Neurodegenerative Disorders and Their Comorbidities-The Case of Valeriana carnosa Sm. (Caprifoliaceae) Studied in Mice - Marcucci_2023_Pharmaceuticals.(Basel)_16_ |
| Author(s) : Marcucci C , Rademacher M , Kamecki F , Pastore V , Bach HG , Ricco RA , Wagner ML , Knez D , Gobec S , Colettis N , Marder M |
| Ref : Pharmaceuticals (Basel) , 16 : , 2023 |
| Abstract : |
| PubMedSearch : Marcucci_2023_Pharmaceuticals.(Basel)_16_ |
| PubMedID: 36678626 |
| Title : 8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases - Knez_2023_Acta.Pharmaceutica.Sinica.B_13_2152 |
| Author(s) : Knez D , Diez-Iriepa D , Chioua M , Gottinger A , Denic M , Chantegreil F , Nachon F , Brazzolotto X , Skrzypczak-Wiercioch A , Meden A , Pislar A , Kos J , Zakelj S , Stojan J , Salat K , Serrano J , Patricia Fernandez AP , Sanchez-Garcia A , Martinez-Murillo R , Binda C , Lopez-Munoz F , Gobec S , Marco-Contelles J |
| Ref : Acta Pharmaceutica Sinica B , 13 :2152 , 2023 |
| Abstract : |
| PubMedSearch : Knez_2023_Acta.Pharmaceutica.Sinica.B_13_2152 |
| PubMedID: 37250172 |
| Gene_locus related to this paper: human-BCHE |
| Title : Pseudo-irreversible butyrylcholinesterase inhibitors: Structure-activity relationships, computational and crystallographic study of the N-dialkyl O-arylcarbamate warhead - Meden_2023_Eur.J.Med.Chem_247_115048 |
| Author(s) : Meden A , Knez D , Brazzolotto X , Modeste F , Perdih A , Pislar A , Zorman M , Zorovic M , Denic M , Pajk S , Zivin M , Nachon F , Gobec S |
| Ref : Eur Journal of Medicinal Chemistry , 247 :115048 , 2023 |
| Abstract : |
| PubMedSearch : Meden_2023_Eur.J.Med.Chem_247_115048 |
| PubMedID: 36586299 |
| Gene_locus related to this paper: human-BCHE |
| Title : Synthesis and Cholinesterase Inhibitory Activity of Selected Indole-Based Compounds - Groselj_2023_Acta.Chim.Slov_70_545 |
| Author(s) : Groselj U , Grsic M , Meden A , Knez D , Jukic M , Svete J , Gobec S |
| Ref : Acta Chim Slov , 70 :545 , 2023 |
| Abstract : |
| PubMedSearch : Groselj_2023_Acta.Chim.Slov_70_545 |
| PubMedID: 38124635 |
| Title : From tryptophan-based amides to tertiary amines: Optimization of a butyrylcholinesterase inhibitor series - Meden_2022_Eur.J.Med.Chem_230_114248 |
| Author(s) : Meden A , Knez D , Brazzolotto X , Nachon F , Dias J , Svete J , Stojan J , Groselj U , Gobec S |
| Ref : Eur Journal of Medicinal Chemistry , 230 :114248 , 2022 |
| Abstract : |
| PubMedSearch : Meden_2022_Eur.J.Med.Chem_230_114248 |
| PubMedID: 35299116 |
| Title : Pseudo-irreversible butyrylcholinesterase inhibitors: SAR, kinetic, computational, and crystallographic study of the N-dialkyl O-arylcarbamate warhead - Meden_2022_Chemrxiv__ |
| Author(s) : Meden A , Knez D , Brazzolotto X , Modeste F , Perdih A , Pislar A , Zorman M , Denic M , Pajk S , Nachon F , Gobec S |
| Ref : Chemrxiv , : , 2022 |
| Abstract : |
| PubMedSearch : Meden_2022_Chemrxiv__ |
| PubMedID: |
| Gene_locus related to this paper: human-BCHE |
| Title : N-Hydroxy-N-Propargylamide Derivatives of Ferulic Acid: Inhibitors of Cholinesterases and Monoamine Oxidases - Bautista-Aguilera_2022_Molecules_27_ |
| Author(s) : Bautista-Aguilera M , Alonso JM , Catto M , Iriepa I , Knez D , Gobec S , Marco-Contelles J |
| Ref : Molecules , 27 : , 2022 |
| Abstract : |
| PubMedSearch : Bautista-Aguilera_2022_Molecules_27_ |
| PubMedID: 36364263 |
| Title : Repurposing of 8-Hydroxyquinoline-based Butyrylcholinesterase and Cathepsin B Ligands as Potent Non-peptidic Deoxyribonuclease I Inhibitors - Gajic_2022_ChemMedChem__ |
| Author(s) : Gajic M , Knez D , Sosic I , Mravljak J , Meden A , Kosak U , Leitzbach L , George S , Hofmann B , Zivkovic A , Steinhilber D , Stark H , Gobec S , Smelcerovic A , Anderluh M |
| Ref : ChemMedChem , : , 2022 |
| Abstract : |
| PubMedSearch : Gajic_2022_ChemMedChem__ |
| PubMedID: 34994078 |
| Title : Screening of Big Pharma's Library against Various in-house Biological Targets - Knez_2022_Molecules_27_ |
| Author(s) : Knez D , Gobec S , Hrast M |
| Ref : Molecules , 27 : , 2022 |
| Abstract : |
| PubMedSearch : Knez_2022_Molecules_27_ |
| PubMedID: 35889355 |
| Title : Polyfunctionalized alpha-Phenyl-tert-butyl(benzyl)nitrones: Multifunctional Antioxidants for Stroke Treatment - Diez-Iriepa_2022_Antioxidants.(Basel)_11_ |
| Author(s) : Diez-Iriepa D , Knez D , Gobec S , Iriepa I , de los Rios C , Bravo I , Lopez-Munoz F , Marco-Contelles J , Hadjipavlou-Litina D |
| Ref : Antioxidants (Basel) , 11 : , 2022 |
| Abstract : |
| PubMedSearch : Diez-Iriepa_2022_Antioxidants.(Basel)_11_ |
| PubMedID: 36139811 |
| Title : Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT6R antagonists with beta-amyloid anti-aggregation properties - Wichur_2021_Eur.J.Med.Chem_225_113792 |
| Author(s) : Wichur T , Godyn J , Goral I , Latacz G , Bucki A , Siwek A , Gluch-Lutwin M , Mordyl B , Sniecikowska J , Walczak M , Knez D , Jukic M , Salat K , Gobec S , Kolaczkowski M , Malawska B , Brazzolotto X , Wieckowska A |
| Ref : Eur Journal of Medicinal Chemistry , 225 :113792 , 2021 |
| Abstract : |
| PubMedSearch : Wichur_2021_Eur.J.Med.Chem_225_113792 |
| PubMedID: 34530376 |
| Gene_locus related to this paper: human-BCHE |
| Title : Discovery of multifunctional anti-Alzheimers agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and gamma-aminobutyric acid transporters - Pasieka_2021_Eur.J.Med.Chem_218_113397 |
| Author(s) : Pasieka A , Panek D , Jonczyk J , Godyn J , Szalaj N , Latacz G , Tabor J , Mezeiova E , Chantegreil F , Dias J , Knez D , Lu J , Pi R , Korabecny J , Brazzolotto X , Gobec S , Hofner G , Wanner K , Wieckowska Q , Malawska B |
| Ref : Eur Journal of Medicinal Chemistry , 218 :113397 , 2021 |
| Abstract : |
| PubMedSearch : Pasieka_2021_Eur.J.Med.Chem_218_113397 |
| PubMedID: 33838585 |
| Title : Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT(6) receptor with anti-aggregation properties against amyloid-beta and tau - Wichur_2021_Eur.J.Med.Chem_225_113783 |
| Author(s) : Wichur T , Pasieka A , Godyn J , Panek D , Goral I , Latacz G , Honkisz-Orzechowska E , Bucki A , Siwek A , Gluch-Lutwin M , Knez D , Brazzolotto X , Gobec S , Kolaczkowski M , Sabate R , Malawska B , Wieckowska A |
| Ref : Eur Journal of Medicinal Chemistry , 225 :113783 , 2021 |
| Abstract : |
| PubMedSearch : Wichur_2021_Eur.J.Med.Chem_225_113783 |
| PubMedID: 34461507 |
| Title : Longitudinal evaluation of a novel BChE PET tracer as an early in vivo biomarker in the brain of a mouse model for Alzheimer disease - Rejc_2021_Theranostics_11_6542 |
| Author(s) : Rejc L , Gomez-Vallejo V , Joya A , Moreno O , Egimendia A , Castellnou P , Rios-Anglada X , Cossio U , Baz Z , Passannante R , Tobalina-Larrea I , Ramos-Cabrer P , Giralt A , Sastre M , Capetillo-Zarate E , Kosak U , Knez D , Gobec S , Marder M , Martin A , Llop J |
| Ref : Theranostics , 11 :6542 , 2021 |
| Abstract : |
| PubMedSearch : Rejc_2021_Theranostics_11_6542 |
| PubMedID: 33995675 |
| Title : Synthesis and Initial Characterization of a Reversible, Selective (18)F-Labeled Radiotracer for Human Butyrylcholinesterase - Gentzsch_2021_Mol.Imaging.Biol__ |
| Author(s) : Gentzsch C , Chen X , Spatz P , Kosak U , Knez D , Nose N , Gobec S , Higuchi T , Decker M |
| Ref : Mol Imaging Biol , : , 2021 |
| Abstract : |
| PubMedSearch : Gentzsch_2021_Mol.Imaging.Biol__ |
| PubMedID: 33660167 |
| Title : Treatment of canine cognitive dysfunction with novel butyrylcholinesterase inhibitor - Zakosek Pipan_2021_Sci.Rep_11_18098 |
| Author(s) : Zakosek Pipan M , Prpar Mihevc S , Strbenc M , Kosak U , German Ilic I , Trontelj J , Zakelj S , Gobec S , Pavlin D , Majdic G |
| Ref : Sci Rep , 11 :18098 , 2021 |
| Abstract : |
| PubMedSearch : Zakosek Pipan_2021_Sci.Rep_11_18098 |
| PubMedID: 34518582 |
| Title : 4-Phenethyl-1-Propargylpiperidine-Derived Dual Inhibitors of Butyrylcholinesterase and Monoamine Oxidase B - Mazej_2021_Molecules_26_ |
| Author(s) : Mazej T , Knez D , Meden A , Gobec S , Sova M |
| Ref : Molecules , 26 : , 2021 |
| Abstract : |
| PubMedSearch : Mazej_2021_Molecules_26_ |
| PubMedID: 34299393 |
| Title : Multitarget 2'-hydroxychalcones as potential drugs for the treatment of neurodegenerative disorders and their comorbidities - Kamecki_2021_Neuropharmacol_201_108837 |
| Author(s) : Kamecki F , Knez D , Carvalho D , Marcucci C , Rademacher M , Higgs J , akelj S , Marcos A , de Tezanos Pinto F , Abin-Carriquiry JA , Gobec S , Colettis N , Marder M |
| Ref : Neuropharmacology , 201 :108837 , 2021 |
| Abstract : |
| PubMedSearch : Kamecki_2021_Neuropharmacol_201_108837 |
| PubMedID: 34653442 |
| Title : Structure-activity relationship study of tryptophan-based butyrylcholinesterase inhibitors - Meden_2020_Eur.J.Med.Chem_208_112766 |
| Author(s) : Meden A , Knez D , Malikowska-Racia N , Brazzolotto X , Nachon F , Svete J , Salat K , Groselj U , Gobec S |
| Ref : Eur Journal of Medicinal Chemistry , 208 :112766 , 2020 |
| Abstract : |
| PubMedSearch : Meden_2020_Eur.J.Med.Chem_208_112766 |
| PubMedID: 32919297 |
| Gene_locus related to this paper: human-BCHE |
| Title : N-alkylpiperidine carbamates as potential anti-Alzheimer's agents - Kosak_2020_Eur.J.Med.Chem_197_112282 |
| Author(s) : Kosak U , Strasek N , Knez N , Jukic M , Zakelj S , Zahirovic A , Pislar A , Brazzolotto X , Nachon F , Kos J , Gobec S , Knez D |
| Ref : Eur Journal of Medicinal Chemistry , 197 :112282 , 2020 |
| Abstract : |
| PubMedSearch : Kosak_2020_Eur.J.Med.Chem_197_112282 |
| PubMedID: 32380361 |
| Gene_locus related to this paper: human-BCHE |
| Title : Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes - Pajk_2020_J.Enzyme.Inhib.Med.Chem_35_498 |
| Author(s) : Pajk S , Knez D , Kosak U , Zorovic M , Brazzolotto X , Coquelle N , Nachon F , Colletier JP , Zivin M , Stojan J , Gobec S |
| Ref : J Enzyme Inhib Med Chem , 35 :498 , 2020 |
| Abstract : |
| PubMedSearch : Pajk_2020_J.Enzyme.Inhib.Med.Chem_35_498 |
| PubMedID: 31914836 |
| Gene_locus related to this paper: human-BCHE |
| Title : Tryptophan-derived butyrylcholinesterase inhibitors as promising leads against Alzheimer's disease - Meden_2019_Chem.Commun.(Camb)_55_3765 |
| Author(s) : Meden A , Knez D , Jukic M , Brazzolotto X , Grsic M , Pislar A , Zahirovic A , Kos J , Nachon F , Svete J , Gobec S , Groselj U |
| Ref : Chem Commun (Camb) , 55 :3765 , 2019 |
| Abstract : |
| PubMedSearch : Meden_2019_Chem.Commun.(Camb)_55_3765 |
| PubMedID: 30864579 |
| Gene_locus related to this paper: human-BCHE |
| Title : 1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease - Wichur_2019_Eur.J.Med.Chem_187_111916 |
| Author(s) : Wichur T , Wieckowska A , Wieckowski K , Godyn J , Jonczyk J , Valdivieso ADR , Panek D , Pasieka A , Sabate R , Knez D , Gobec S , Malawska B |
| Ref : Eur Journal of Medicinal Chemistry , 187 :111916 , 2019 |
| Abstract : |
| PubMedSearch : Wichur_2019_Eur.J.Med.Chem_187_111916 |
| PubMedID: 31812794 |
| Title : Biological Evaluation of 8-Hydroxyquinolines as Multi-Target Directed Ligands for Treating Alzheimer's Disease - Knez_2019_Curr.Alzheimer.Res_16_801 |
| Author(s) : Knez D , Sosic I , Pislar A , Mitrovic A , Jukic M , Kos J , Gobec S |
| Ref : Curr Alzheimer Res , 16 :801 , 2019 |
| Abstract : |
| PubMedSearch : Knez_2019_Curr.Alzheimer.Res_16_801 |
| PubMedID: 31660830 |
| Title : Novel Multitarget-Directed Ligands Aiming at Symptoms and Causes of Alzheimer's Disease - Wieckowska_2018_ACS.Chem.Neurosci_9_1195 |
| Author(s) : Wieckowska A , Wichur T , Godyn J , Bucki A , Marcinkowska M , Siwek A , Wieckowski K , Zareba P , Knez D , Gluch-Lutwin M , Kazek G , Latacz G , Mika K , Kolaczkowski M , Korabecny J , Soukup O , Benkova M , Kiec-Kononowicz K , Gobec S , Malawska B |
| Ref : ACS Chem Neurosci , 9 :1195 , 2018 |
| Abstract : |
| PubMedSearch : Wieckowska_2018_ACS.Chem.Neurosci_9_1195 |
| PubMedID: 29384656 |
| Title : Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer's Agents - Panek_2018_ACS.Chem.Neurosci_9_1074 |
| Author(s) : Panek D , Wieckowska A , Jonczyk J , Godyn J , Bajda M , Wichur T , Pasieka A , Knez D , Pislar A , Korabecny J , Soukup O , Sepsova V , Sabate R , Kos J , Gobec S , Malawska B |
| Ref : ACS Chem Neurosci , 9 :1074 , 2018 |
| Abstract : |
| PubMedSearch : Panek_2018_ACS.Chem.Neurosci_9_1074 |
| PubMedID: 29345897 |
| Title : Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities - Knez_2018_Eur.J.Med.Chem_156_598 |
| Author(s) : Knez D , Coquelle N , Pislar A , Zakelj S , Jukic M , Sova M , Mravljak J , Nachon F , Brazzolotto X , Kos J , Colletier JP , Gobec S |
| Ref : Eur Journal of Medicinal Chemistry , 156 :598 , 2018 |
| Abstract : |
| PubMedSearch : Knez_2018_Eur.J.Med.Chem_156_598 |
| PubMedID: 30031971 |
| Gene_locus related to this paper: human-BCHE |
| Title : Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3-Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer Agents - Panek_2018_Molecules_23_ |
| Author(s) : Panek D , Wieckowska A , Pasieka A , Godyn J , Jonczyk J , Bajda M , Knez D , Gobec S , Malawska B |
| Ref : Molecules , 23 : , 2018 |
| Abstract : |
| PubMedSearch : Panek_2018_Molecules_23_ |
| PubMedID: 29414887 |
| Title : The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity - Kosak_2018_J.Med.Chem_61_119 |
| Author(s) : Kosak U , Brus B , Knez D , Zakelj S , Trontelj J , Pislar A , Sink R , Jukic M , Zivin M , Podkowa A , Nachon F , Brazzolotto X , Stojan J , Kos J , Coquelle N , Salat K , Colletier JP , Gobec S |
| Ref : Journal of Medicinal Chemistry , 61 :119 , 2018 |
| Abstract : |
| PubMedSearch : Kosak_2018_J.Med.Chem_61_119 |
| PubMedID: 29227101 |
| Gene_locus related to this paper: human-BCHE |
| Title : N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents - Kosak_2017_Bioorg.Med.Chem_25_633 |
| Author(s) : Kosak U , Knez D , Coquelle N , Brus B , Pislar A , Nachon F , Brazzolotto X , Kos J , Colletier JP , Gobec S |
| Ref : Bioorganic & Medicinal Chemistry , 25 :633 , 2017 |
| Abstract : |
| PubMedSearch : Kosak_2017_Bioorg.Med.Chem_25_633 |
| PubMedID: 27908752 |
| Gene_locus related to this paper: human-BCHE |
| Title : Dual inhibitors of cholinesterases and monoamine oxidases for Alzheimer's disease - Knez_2017_Future.Med.Chem_9_811 |
| Author(s) : Knez D , Sova M , Kosak U , Gobec S |
| Ref : Future Med Chem , 9 :811 , 2017 |
| Abstract : |
| PubMedSearch : Knez_2017_Future.Med.Chem_9_811 |
| PubMedID: 28504893 |
| Title : Synthesis and preliminary biological evaluations of (+)-isocampholenic acid-derived amides - Groselj_2016_Mol.Divers_20_667 |
| Author(s) : Groselj U , Golobic A , Knez D , Hrast M , Gobec S , Ricko S , Svete J |
| Ref : Mol Divers , 20 :667 , 2016 |
| Abstract : |
| PubMedSearch : Groselj_2016_Mol.Divers_20_667 |
| PubMedID: 27017352 |
| Title : Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta - Hebda_2016_Molecules_21_ |
| Author(s) : Hebda M , Bajda M , Wieckowska A , Szalaj N , Pasieka A , Panek D , Godyn J , Wichur T , Knez D , Gobec S , Malawska B |
| Ref : Molecules , 21 : , 2016 |
| Abstract : |
| PubMedSearch : Hebda_2016_Molecules_21_ |
| PubMedID: 27023510 |
| Title : Development of an in-vivo active reversible butyrylcholinesterase inhibitor - Kosak_2016_Sci.Rep_6_39495 |
| Author(s) : Kosak U , Brus B , Knez D , Sink R , Zakelj S , Trontelj J , Pislar A , Slenc J , Gobec M , Zivin M , Tratnjek L , Perse M , Salat K , Podkowa A , Filipek B , Nachon F , Brazzolotto X , Wieckowska A , Malawska B , Stojan J , Rascan IM , Kos J , Coquelle N , Colletier JP , Gobec S |
| Ref : Sci Rep , 6 :39495 , 2016 |
| Abstract : |
| PubMedSearch : Kosak_2016_Sci.Rep_6_39495 |
| PubMedID: 28000737 |
| Gene_locus related to this paper: human-BCHE |
| Title : Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer's Disease - Dgachi_2016_Molecules_21_ |
| Author(s) : Dgachi Y , Bautista-Aguilera OM , Benchekroun M , Martin H , Bonet A , Knez D , Godyn J , Malawska B , Gobec S , Chioua M , Janockova J , Soukup O , Chabchoub F , Marco-Contelles J , Ismaili L |
| Ref : Molecules , 21 : , 2016 |
| Abstract : |
| PubMedSearch : Dgachi_2016_Molecules_21_ |
| PubMedID: 27187348 |
| Title : Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation - Panek_2016_Eur.J.Med.Chem_125_676 |
| Author(s) : Panek D , Wieckowska A , Wichur T , Bajda M , Godyn J , Jonczyk J , Mika K , Janockova J , Soukup O , Knez D , Korabecny J , Gobec S , Malawska B |
| Ref : Eur Journal of Medicinal Chemistry , 125 :676 , 2016 |
| Abstract : |
| PubMedSearch : Panek_2016_Eur.J.Med.Chem_125_676 |
| PubMedID: 27721153 |
| Title : Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT6 receptor antagonists. Design, synthesis and biological evaluation - Wieckowska_2016_Eur.J.Med.Chem_124_63 |
| Author(s) : Wieckowska A , Kolaczkowski M , Bucki A , Godyn J , Marcinkowska M , Wieckowski K , Zareba P , Siwek A , Kazek G , Gluch-Lutwin M , Mierzejewski P , Bienkowski P , Sienkiewicz-Jarosz H , Knez D , Wichur T , Gobec S , Malawska B |
| Ref : Eur Journal of Medicinal Chemistry , 124 :63 , 2016 |
| Abstract : |
| PubMedSearch : Wieckowska_2016_Eur.J.Med.Chem_124_63 |
| PubMedID: 27560283 |
| Title : Synthesis and Biological Assessment of Racemic Benzochromenopyrimidinimines as Antioxidant, Cholinesterase, and Abeta1-42 Aggregation Inhibitors for Alzheimer's Disease Therapy - Dgachi_2016_ChemMedChem_11_1318 |
| Author(s) : Dgachi Y , Ismaili L , Knez D , Benchekroun M , Martin H , Szalaj N , Wehle S , Bautista-Aguilera OM , Luzet V , Bonnet A , Malawska B , Gobec S , Chioua M , Decker M , Chabchoub F , Marco-Contelles J |
| Ref : ChemMedChem , 11 :1318 , 2016 |
| Abstract : |
| PubMedSearch : Dgachi_2016_ChemMedChem_11_1318 |
| PubMedID: 26804623 |
| Title : Development of multifunctional, heterodimeric isoindoline-1,3-dione derivatives as cholinesterase and beta-amyloid aggregation inhibitors with neuroprotective properties - Guzior_2015_Eur.J.Med.Chem_92C_738 |
| Author(s) : Guzior N , Bajda M , Skrok M , Kurpiewska K , Lewinski K , Brus B , Pislar A , Kos J , Gobec S , Malawska B |
| Ref : Eur Journal of Medicinal Chemistry , 92C :738 , 2015 |
| Abstract : |
| PubMedSearch : Guzior_2015_Eur.J.Med.Chem_92C_738 |
| PubMedID: 25621991 |
| Title : Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents - Knez_2015_Bioorg.Med.Chem_23_4442 |
| Author(s) : Knez D , Brus B , Coquelle N , Sosic I , Sink R , Brazzolotto X , Mravljak J , Colletier JP , Gobec S |
| Ref : Bioorganic & Medicinal Chemistry , 23 :4442 , 2015 |
| Abstract : |
| PubMedSearch : Knez_2015_Bioorg.Med.Chem_23_4442 |
| PubMedID: 26116179 |
| Gene_locus related to this paper: human-BCHE |
| Title : Multiple Ligands Targeting Cholinesterases and beta-Amyloid: Synthesis, Biological Evaluation of Heterodimeric Compounds with Benzylamine Pharmacophore - Szalaj_2015_Arch.Pharm.(Weinheim)_348_556 |
| Author(s) : Szalaj N , Bajda M , Dudek K , Brus B , Gobec S , Malawska B |
| Ref : Arch Pharm (Weinheim) , 348 :556 , 2015 |
| Abstract : |
| PubMedSearch : Szalaj_2015_Arch.Pharm.(Weinheim)_348_556 |
| PubMedID: 26032855 |
| Title : Isoindoline-1,3-dione derivatives targeting cholinesterases: Design, synthesis and biological evaluation of potential anti-Alzheimer's agents - Guzior_2015_Bioorg.Med.Chem_23_1629 |
| Author(s) : Guzior N , Bajda M , Rakoczy J , Brus B , Gobec S , Malawska B |
| Ref : Bioorganic & Medicinal Chemistry , 23 :1629 , 2015 |
| Abstract : |
| PubMedSearch : Guzior_2015_Bioorg.Med.Chem_23_1629 |
| PubMedID: 25707322 |
| Title : Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with beta-amyloid anti-aggregation properties and beneficial effects on memory in vivo - Wieckowska_2015_Bioorg.Med.Chem_23_2445 |
| Author(s) : Wieckowska A , Wieckowski K , Bajda M , Brus B , Salat K , Czerwinska P , Gobec S , Filipek B , Malawska B |
| Ref : Bioorganic & Medicinal Chemistry , 23 :2445 , 2015 |
| Abstract : |
| PubMedSearch : Wieckowska_2015_Bioorg.Med.Chem_23_2445 |
| PubMedID: 25868744 |
| Title : LiSiCA: A Software for Ligand-Based Virtual Screening and Its Application for the Discovery of Butyrylcholinesterase Inhibitors - Lesnik_2015_J.Chem.Inf.Model_55_1521 |
| Author(s) : Lesnik S , Stular T , Brus B , Knez D , Gobec S , Janezic D , Konc J |
| Ref : J Chem Inf Model , 55 :1521 , 2015 |
| Abstract : |
| PubMedSearch : Lesnik_2015_J.Chem.Inf.Model_55_1521 |
| PubMedID: 26158767 |
| Title : Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor - Brus_2014_J.Med.Chem_57_8167 |
| Author(s) : Brus B , Kosak U , Turk S , Pislar A , Coquelle N , Kos J , Stojan J , Colletier JP , Gobec S |
| Ref : Journal of Medicinal Chemistry , 57 :8167 , 2014 |
| Abstract : |
| PubMedSearch : Brus_2014_J.Med.Chem_57_8167 |
| PubMedID: 25226236 |
| Gene_locus related to this paper: human-BCHE |
| Title : Exploring the aryl esterase catalysis of paraoxonase-1 through solvent kinetic isotope effects and phosphonate-based isosteric analogues of the tetrahedral reaction intermediate - Bavec_2014_Biochimie_106_184 |
| Author(s) : Bavec A , Knez D , Makovec T , Stojan J , Gobec S , Golicnik M |
| Ref : Biochimie , 106 :184 , 2014 |
| Abstract : |
| PubMedSearch : Bavec_2014_Biochimie_106_184 |
| PubMedID: 25180809 |
| Title : Phosphonate inhibitors of antigen 85C, a crucial enzyme involved in the biosynthesis of the Mycobacterium tuberculosis cell wall - Gobec_2004_Bioorg.Med.Chem.Lett_14_3559 |
| Author(s) : Gobec S , Plantan I , Mravljak J , Wilson RA , Besra GS , Kikelj D |
| Ref : Bioorganic & Medicinal Chemistry Lett , 14 :3559 , 2004 |
| Abstract : |
| PubMedSearch : Gobec_2004_Bioorg.Med.Chem.Lett_14_3559 |
| PubMedID: 15177473 |