O-3841

General

Type : Organophosphate, Lipase inhibitor

Chemical_Nomenclature : (Z)-1-[1-(fluoro-methyl-oxidophosphaniumyl)oxy-3-methoxypropan-2-yl]oxyoctadec-9-ene

Canonical SMILES : CCCCCCCCC=CCCCCCCCCOC(COC)CO[P+](C)([O-])F

InChI : InChI=1S\/C23H46FO4P\/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-27-23(21-26-2)22-28-29(3,24)25\/h11-12,23H,4-10,13-22H2,1-3H3\/b12-11-

InChIKey : DEONOLSRIXDMGT-QXMHVHEDSA-N

Other name(s) :


MW : 436.6

Formula : C23H46FO4P

CAS_number :

PubChem : 102182137

UniChem : DEONOLSRIXDMGT-QXMHVHEDSA-N

Target

Families : O-3841 ligand of proteins in family
Lipase_3

Protein :
human-DAGLA human-DAGLB

References (2)

Title : Assay and inhibition of diacylglycerol lipase activity - Johnston_2012_Bioorg.Med.Chem.Lett_22_4585
Author(s) : Johnston M , Bhatt SR , Sikka S , Mercier RW , West JM , Makriyannis A , Gatley SJ , Duclos RI, Jr.
Ref : Bioorganic & Medicinal Chemistry Lett , 22 :4585 , 2012
Abstract :
PubMedSearch : Johnston_2012_Bioorg.Med.Chem.Lett_22_4585
PubMedID: 22738638

Title : Development of the first potent and specific inhibitors of endocannabinoid biosynthesis - Bisogno_2006_Biochim.Biophys.Acta_1761_205
Author(s) : Bisogno T , Cascio MG , Saha B , Mahadevan A , Urbani P , Minassi A , Appendino G , Saturnino C , Martin B , Razdan R , Di Marzo V
Ref : Biochimica & Biophysica Acta , 1761 :205 , 2006
Abstract :
PubMedSearch : Bisogno_2006_Biochim.Biophys.Acta_1761_205
PubMedID: 16466961
Gene_locus related to this paper: human-DAGLA , human-DAGLB