human-DAGLB

Homo sapiens (Human) DAGLB Sn1-specific diacylglycerol lipase beta kccr13l FLJ36639

Comment

Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.DAGLB hydrolyses diacyglycerols preferencially on the sn-1 position. Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction. (Liu et al.<\/A>)

Relationship

Family : Lipase_3

Block : L

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

No mutation

No structure

No kinetic

Sequence

Peptide

MPGMVLFGRR WAIASDDLVF PGFFELVVRV LWWIGILTLY LMHRGKLDCA GGALLSSYLI VLMILLAVVI CTVSAIMCVS MRGTICNPGP RKSMSKLLYI RLALFFPEMV WASLGAAWVA DGVQCDRTVV NGIIATVVVS WIIIAATVVS IIIVFDPLGG KMAPYSSAGP SHLDSHDSSQ LLNGLKTAAT SVWETRIKLL CCCIGKDDHT RVAFSSTAEL FSTYFSDTDL VPSDIAAGLA LLHQQQDNIR NNQEPAQVVC HAPGSSQEAD LDAELENCHH YMQFAAAAYG WPLYIYRNPL TGLCRIGGDC CRSRTTDYDL VGGDQLNCHF GSILHTTGLQ YRDFIHVSFH DKVYELPFLV ALDHRKESVV VAVRGTMSLQ DVLTDLSAES EVLDVECEVQ DRLAHKGISQ AARYVYQRLI NDGILSQAFS IAPEYRLVIV GHSLGGGAAA LLATMLRAAY PQVRCYAFSP PRGLWSKALQ EYSQSFIVSL VLGKDVIPRL SVTNLEDLKR RILRVVAHCN KPKYKILLHG LWYELFGGNP NNLPTELDGG DQEVLTQPLL GEQSLLTRWS PAYSFSSDSP LDSSPKYPPL YPPGRIIHLQ EEGASGRFGC CSAAHYSAKW SHEAEFSKIL IGPKMLTDHM PDILMRALDS VVSDRAACVS CPAQGVSSVD VA

References (18)

Title : Pharmacological diacylglycerol lipase inhibition impairs contextual fear extinction in mice - Ramos-Medina_2024_Psychopharmacology.(Berl)__
Author(s) : Ramos-Medina L , Rosas-Vidal LE , Patel S
Ref : Psychopharmacology (Berl) , : , 2024
PubMedID: 38182791
Gene_locus related to this paper: human-DAGLA , human-DAGLB

Title : Inhibition of diacylglycerol lipase beta modulates lipid and endocannabinoid levels in the ex vivo human placenta - Berger_2023_Front.Endocrinol.(Lausanne)_14_1092024
Author(s) : Berger N , van der Wel T , Hirschmugl B , Baernthaler T , Gindlhuber J , Fawzy N , Eichmann T , Birner-Gruenberger R , Zimmermann R , van der Stelt M , Wadsack C
Ref : Front Endocrinol (Lausanne) , 14 :1092024 , 2023
PubMedID: 36864832
Gene_locus related to this paper: human-DAGLA , human-DAGLB

Title : DAGLbeta is the principal synthesizing enzyme of 2-AG and promotes aggressive intrahepatic cholangiocarcinoma via AP-1\/DAGLbeta\/miR4516 feedforward circuitry - Ma_2023_Am.J.Physiol.Gastrointest.Liver.Physiol__
Author(s) : Ma M , Zeng G , Tan B , Zhao G , Su Q , Zhang W , Song Y , Liang J , Xu B , Wang Z , Chen J , Hou M , Yang C , Yun J , Huang Y , Lin Y , Chen D , Han Y , DeMorrow S , Liang L , Lai J , Huang L
Ref : American Journal of Physiology Gastrointest Liver Physiol , : , 2023
PubMedID: 37366545
Gene_locus related to this paper: human-DAGLB

Title : Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction - Liu_2022_Nat.Commun_13_3490
Author(s) : Liu Z , Yang N , Dong J , Tian W , Chang L , Ma J , Guo J , Tan J , Dong A , He K , Zhou J , Cinar R , Wu J , Salinas AG , Sun L , Kumar M , Sullivan BT , Oldham BB , Pitz V , Makarious MB , Ding J , Kung J , Xie C , Hawes SL , Wang L , Wang T , Chan P , Zhang Z , Le W , Chen S , Lovinger DM , Blauwendraat C , Singleton AB , Cui G , Li Y , Cai H , Tang B
Ref : Nat Commun , 13 :3490 , 2022
PubMedID: 35715418
Gene_locus related to this paper: human-DAGLB , mouse-DGLB

Title : Inhibition of DAGLbeta as a therapeutic target for pain in sickle cell disease - Khasabova_2022_Haematologica__
Author(s) : Khasabova IA , Gable J , Johns M , Khasabov SG , Kalyuzhny AE , Golovko MY , Golovko SA , Kiven S , Gupta K , Seybold VS , Simone DA
Ref : Haematologica , : , 2022
PubMedID: 35615929
Gene_locus related to this paper: human-DAGLB

Title : In situ localization of diacylglycerol lipase alpha and beta producing an endocannabinoid 2-arachidonoylglycerol and of cannabinoid receptor 1 in the primary oocytes of postnatal mice - Kamnate_2021_J.Anat__
Author(s) : Kamnate A , Sirisin J , Polsan Y , Chomphoo S , Watanabe M , Kondo H , Hipkaeo W
Ref : Journal of Anatomy , : , 2021
PubMedID: 33398893
Gene_locus related to this paper: human-DAGLA , human-DAGLB , mouse-DGLB , mouse-q6wqj1

Title : Diacylglycerol Lipase-beta Knockout Mice Display a Sex-Dependent Attenuation of Traumatic Brain Injury-Induced Mortality with No Impact on Memory or Other Functional Consequences - O'Brien_2021_Cannabis.Cannabinoid.Res__
Author(s) : O'Brien LD , Smith TL , Donvito G , Cravatt BF , Newton J , Spiegel S , Reeves TM , Phillips LL , Lichtman AH
Ref : Cannabis Cannabinoid Res , : , 2021
PubMedID: 34142866
Gene_locus related to this paper: human-DAGLB , mouse-DGLB

Title : Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition - Ogasawara_2016_Proc.Natl.Acad.Sci.U.S.A_113_26
Author(s) : Ogasawara D , Deng H , Viader A , Baggelaar MP , Breman A , den Dulk H , van den Nieuwendijk AM , Soethoudt M , van der Wel T , Zhou J , Overkleeft HS , Sanchez-Alavez M , Mori S , Nguyen W , Conti B , Liu X , Chen Y , Liu QS , Cravatt BF , van der Stelt M
Ref : Proc Natl Acad Sci U S A , 113 :26 , 2016
PubMedID: 26668358
Gene_locus related to this paper: human-DAGLA , human-DAGLB

Title : Assay and Inhibition of the Purified Catalytic Domain of Diacylglycerol Lipase Beta - Singh_2016_Biochemistry_55_2713
Author(s) : Singh PK , Markwick R , Lu L , Howell FV , Williams G , Doherty P
Ref : Biochemistry , 55 :2713 , 2016
PubMedID: 27115711
Gene_locus related to this paper: human-DAGLB

Title : Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons - Baggelaar_2015_J.Am.Chem.Soc_137_8851
Author(s) : Baggelaar MP , Chameau PJ , Kantae V , Hummel J , Hsu KL , Janssen F , van der Wel T , Soethoudt M , Deng H , den Dulk H , Allara M , Florea BI , Di Marzo V , Wadman WJ , Kruse CG , Overkleeft HS , Hankemeier T , Werkman TR , Cravatt BF , van der Stelt M
Ref : Journal of the American Chemical Society , 137 :8851 , 2015
PubMedID: 26083464
Gene_locus related to this paper: human-DAGLA , human-DAGLB

Title : A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects - Bisogno_2013_Br.J.Pharmacol_169_784
Author(s) : Bisogno T , Mahadevan A , Coccurello R , Chang JW , Allara M , Chen Y , Giacovazzo G , Lichtman A , Cravatt BF , Moles A , Di Marzo V
Ref : British Journal of Pharmacology , 169 :784 , 2013
PubMedID: 23072382
Gene_locus related to this paper: human-DAGLA , human-DAGLB

Title : Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis - Hsu_2013_J.Med.Chem_56_8257
Author(s) : Hsu KL , Tsuboi K , Whitby LR , Speers AE , Pugh H , Inloes J , Cravatt BF
Ref : Journal of Medicinal Chemistry , 56 :8257 , 2013
PubMedID: 24152245
Gene_locus related to this paper: human-DAGLB

Title : DAGLbeta inhibition perturbs a lipid network involved in macrophage inflammatory responses - Hsu_2012_Nat.Chem.Biol_8_999
Author(s) : Hsu KL , Tsuboi K , Adibekian A , Pugh H , Masuda K , Cravatt BF
Ref : Nat Chemical Biology , 8 :999 , 2012
PubMedID: 23103940
Gene_locus related to this paper: human-DAGLA , human-DAGLB

Title : DAGL-dependent endocannabinoid signalling: roles in axonal pathfinding, synaptic plasticity and adult neurogenesis - Oudin_2011_Eur.J.Neurosci_34_1634
Author(s) : Oudin MJ , Hobbs C , Doherty P
Ref : European Journal of Neuroscience , 34 :1634 , 2011
PubMedID: 22103420
Gene_locus related to this paper: human-DAGLA , human-DAGLB , mouse-DGLB , mouse-q6wqj1

Title : Development of a potent inhibitor of 2-arachidonoylglycerol hydrolysis with antinociceptive activity in vivo - Bisogno_2009_Biochim.Biophys.Acta_1791_53
Author(s) : Bisogno T , Ortar G , Petrosino S , Morera E , Palazzo E , Nalli M , Maione S , Di Marzo V
Ref : Biochimica & Biophysica Acta , 1791 :53 , 2009
PubMedID: 19027877
Gene_locus related to this paper: human-DAGLA , human-DAGLB

Title : Development of the first potent and specific inhibitors of endocannabinoid biosynthesis - Bisogno_2006_Biochim.Biophys.Acta_1761_205
Author(s) : Bisogno T , Cascio MG , Saha B , Mahadevan A , Urbani P , Minassi A , Appendino G , Saturnino C , Martin B , Razdan R , Di Marzo V
Ref : Biochimica & Biophysica Acta , 1761 :205 , 2006
PubMedID: 16466961
Gene_locus related to this paper: human-DAGLA , human-DAGLB

Title : Complete sequencing and characterization of 21,243 full-length human cDNAs - Ota_2004_Nat.Genet_36_40
Author(s) : Ota T , Suzuki Y , Nishikawa T , Otsuki T , Sugiyama T , Irie R , Wakamatsu A , Hayashi K , Sato H , Nagai K , Kimura K , Makita H , Sekine M , Obayashi M , Nishi T , Shibahara T , Tanaka T , Ishii S , Yamamoto J , Saito K , Kawai Y , Isono Y , Nakamura Y , Nagahari K , Murakami K , Yasuda T , Iwayanagi T , Wagatsuma M , Shiratori A , Sudo H , Hosoiri T , Kaku Y , Kodaira H , Kondo H , Sugawara M , Takahashi M , Kanda K , Yokoi T , Furuya T , Kikkawa E , Omura Y , Abe K , Kamihara K , Katsuta N , Sato K , Tanikawa M , Yamazaki M , Ninomiya K , Ishibashi T , Yamashita H , Murakawa K , Fujimori K , Tanai H , Kimata M , Watanabe M , Hiraoka S , Chiba Y , Ishida S , Ono Y , Takiguchi S , Watanabe S , Yosida M , Hotuta T , Kusano J , Kanehori K , Takahashi-Fujii A , Hara H , Tanase TO , Nomura Y , Togiya S , Komai F , Hara R , Takeuchi K , Arita M , Imose N , Musashino K , Yuuki H , Oshima A , Sasaki N , Aotsuka S , Yoshikawa Y , Matsunawa H , Ichihara T , Shiohata N , Sano S , Moriya S , Momiyama H , Satoh N , Takami S , Terashima Y , Suzuki O , Nakagawa S , Senoh A , Mizoguchi H , Goto Y , Shimizu F , Wakebe H , Hishigaki H , Watanabe T , Sugiyama A , Takemoto M , Kawakami B , Watanabe K , Kumagai A , Itakura S , Fukuzumi Y , Fujimori Y , Komiyama M , Tashiro H , Tanigami A , Fujiwara T , Ono T , Yamada K , Fujii Y , Ozaki K , Hirao M , Ohmori Y , Kawabata A , Hikiji T , Kobatake N , Inagaki H , Ikema Y , Okamoto S , Okitani R , Kawakami T , Noguchi S , Itoh T , Shigeta K , Senba T , Matsumura K , Nakajima Y , Mizuno T , Morinaga M , Sasaki M , Togashi T , Oyama M , Hata H , Komatsu T , Mizushima-Sugano J , Satoh T , Shirai Y , Takahashi Y , Nakagawa K , Okumura K , Nagase T , Nomura N , Kikuchi H , Masuho Y , Yamashita R , Nakai K , Yada T , Ohara O , Isogai T , Sugano S
Ref : Nat Genet , 36 :40 , 2004
PubMedID: 14702039
Gene_locus related to this paper: human-ABHD1 , human-ABHD4 , human-ABHD12 , human-ABHD16A , human-ACOT1 , human-LDAH , human-ABHD18 , human-CES1 , human-CES4A , human-CES5A , human-CPVL , human-DAGLB , human-EPHX2 , human-KANSL3 , human-LIPA , human-LPL , human-MEST , human-NDRG1 , human-NLGN1 , human-NLGN4X , human-PRCP , human-PRSS16 , human-SERAC1 , human-TMEM53

Title : Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain - Bisogno_2003_J.Cell.Biol_163_463
Author(s) : Bisogno T , Howell F , Williams G , Minassi A , Cascio MG , Ligresti A , Matias I , Schiano-Moriello A , Paul P , Williams EJ , Gangadharan U , Hobbs C , Di Marzo V , Doherty P
Ref : Journal of Cell Biology , 163 :463 , 2003
PubMedID: 14610053
Gene_locus related to this paper: human-DAGLA , human-DAGLB , mouse-DGLB , mouse-q6wqj1