| Title : Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization - Butini_2024_J.Med.Chem__ |
| Author(s) : Butini S , Grether U , Jung KM , Ligresti A , Allara M , Postmus AGJ , Maramai S , Brogi S , Papa A , Carullo G , Sykes D , Veprintsev D , Federico S , Grillo A , Di Guglielmo B , Ramunno A , Stevens AF , Heer D , Lamponi S , Gemma S , Benz J , Di Marzo V , van der Stelt M , Piomelli D , Campiani G |
| Ref : Journal of Medicinal Chemistry , : , 2024 |
| Abstract : |
| PubMedSearch : Butini_2024_J.Med.Chem__ |
| PubMedID: 38241614 |
| Gene_locus related to this paper: human-MGLL |
| Title : The endocannabinoidome in human placenta: Possible contribution to the pathogenesis of preeclampsia - Maia_2023_Biofactors__ |
| Author(s) : Maia J , Iannotti FA , Piscitelli F , Fonseca BM , Braga A , Braga J , Teixeira N , Di Marzo V , Correia-da-Silva G |
| Ref : Biofactors , : , 2023 |
| Abstract : |
| PubMedSearch : Maia_2023_Biofactors__ |
| PubMedID: 37092955 |
| Title : Genetic Manipulation of sn-1-Diacylglycerol Lipase and CB(1) Cannabinoid Receptor Gain-of-Function Uncover Neuronal 2-Linoleoyl Glycerol Signaling in Drosophila melanogaster - Tortoriello_2021_Cannabis.Cannabinoid.Res_6_119 |
| Author(s) : Tortoriello G , Beiersdorf J , Romani S , Williams G , Cameron GA , Mackie K , Williams MJ , Di Marzo V , Keimpema E , Doherty P , Harkany T |
| Ref : Cannabis Cannabinoid Res , 6 :119 , 2021 |
| Abstract : |
| PubMedSearch : Tortoriello_2021_Cannabis.Cannabinoid.Res_6_119 |
| PubMedID: 33912677 |
| Gene_locus related to this paper: drome-CG33174 |
| Title : Role of 2-Arachidonoyl-Glycerol and CB1 Receptors in Orexin-A-Mediated Prevention of Oxygen-Glucose Deprivation-Induced Neuronal Injury - Palomba_2020_Cells_9_ |
| Author(s) : Palomba L , Motta A , Imperatore R , Piscitelli F , Capasso R , Mastroiacovo F , Battaglia G , Bruno V , Cristino L , Di Marzo V |
| Ref : Cells , 9 : , 2020 |
| Abstract : |
| PubMedSearch : Palomba_2020_Cells_9_ |
| PubMedID: 32575773 |
| Title : Mgll Knockout Mouse Resistance to Diet-Induced Dysmetabolism Is Associated with Altered Gut Microbiota - Dione_2020_Cells_9_ |
| Author(s) : Dione N , Lacroix S , Taschler U , Deschenes T , Abolghasemi A , Leblanc N , Di Marzo V , Silvestri C |
| Ref : Cells , 9 : , 2020 |
| Abstract : |
| PubMedSearch : Dione_2020_Cells_9_ |
| PubMedID: 33348740 |
| Gene_locus related to this paper: mouse-MGLL |
| Title : Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment - Montanari_2019_Eur.J.Med.Chem_178_243 |
| Author(s) : Montanari S , Mahmoud AM , Pruccoli L , Rabbito A , Naldi M , Petralla S , Moraleda I , Bartolini M , Monti B , Iriepa I , Belluti F , Gobbi S , Di Marzo V , Bisi A , Tarozzi A , Ligresti A , Rampa A |
| Ref : Eur Journal of Medicinal Chemistry , 178 :243 , 2019 |
| Abstract : |
| PubMedSearch : Montanari_2019_Eur.J.Med.Chem_178_243 |
| PubMedID: 31185414 |
| Title : Human leukocytes differentially express endocannabinoid-glycerol lipases and hydrolyze 2-arachidonoyl-glycerol and its metabolites from the 15-lipoxygenase and cyclooxygenase pathways - Turcotte_2019_J.Leukoc.Biol_106_1337 |
| Author(s) : Turcotte C , Dumais E , Archambault AS , Martin C , Blanchet MR , Bissonnette E , Boulet LP , Laviolette M , Di Marzo V , Flamand N |
| Ref : J Leukoc Biol , 106 :1337 , 2019 |
| Abstract : |
| PubMedSearch : Turcotte_2019_J.Leukoc.Biol_106_1337 |
| PubMedID: 31556464 |
| Gene_locus related to this paper: human-ABHD6 , human-ABHD12 , human-ABHD16A , human-CES1 , human-LYPLA2 , human-PPT1 |
| Title : Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity - Soethoudt_2017_Nat.Commun_8_13958 |
| Author(s) : Soethoudt M , Grether U , Fingerle J , Grim TW , Fezza F , De Petrocellis L , Ullmer C , Rothenhausler B , Perret C , van Gils N , Finlay D , MacDonald C , Chicca A , Gens MD , Stuart J , de Vries H , Mastrangelo N , Xia L , Alachouzos G , Baggelaar MP , Martella A , Mock ED , Deng H , Heitman LH , Connor M , Di Marzo V , Gertsch J , Lichtman AH , Maccarrone M , Pacher P , Glass M , van der Stelt M |
| Ref : Nat Commun , 8 :13958 , 2017 |
| Abstract : |
| PubMedSearch : Soethoudt_2017_Nat.Commun_8_13958 |
| PubMedID: 28045021 |
| Title : Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474 - van Esbroeck_2017_Science_356_1084 |
| Author(s) : van Esbroeck ACM , Janssen APA , Cognetta AB, 3rd , Ogasawara D , Shpak G , van der Kroeg M , Kantae V , Baggelaar MP , de Vrij FMS , Deng H , Allara M , Fezza F , Lin Z , van der Wel T , Soethoudt M , Mock ED , den Dulk H , Baak IL , Florea BI , Hendriks G , De Petrocellis L , Overkleeft HS , Hankemeier T , De Zeeuw CI , Di Marzo V , Maccarrone M , Cravatt BF , Kushner SA , van der Stelt M |
| Ref : Science , 356 :1084 , 2017 |
| Abstract : |
| PubMedSearch : van Esbroeck_2017_Science_356_1084 |
| PubMedID: 28596366 |
| Title : Pharmacological inhibition of MAGL attenuates experimental colon carcinogenesis - Pagano_2017_Pharmacol.Res_119_227 |
| Author(s) : Pagano E , Borrelli F , Orlando P , Romano B , Monti M , Morbidelli L , Aviello G , Imperatore R , Capasso R , Piscitelli F , Buono L , Di Marzo V , Izzo AA |
| Ref : Pharmacol Res , 119 :227 , 2017 |
| Abstract : |
| PubMedSearch : Pagano_2017_Pharmacol.Res_119_227 |
| PubMedID: 28193521 |
| Title : Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain - Brindisi_2016_J.Med.Chem_59_2612 |
| Author(s) : Brindisi M , Maramai S , Gemma S , Brogi S , Grillo A , Di Cesare Mannelli L , Gabellieri E , Lamponi S , Saponara S , Gorelli B , Tedesco D , Bonfiglio T , Landry C , Jung KM , Armirotti A , Luongo L , Ligresti A , Piscitelli F , Bertucci C , Dehouck MP , Campiani G , Maione S , Ghelardini C , Pittaluga A , Piomelli D , Di Marzo V , Butini S |
| Ref : Journal of Medicinal Chemistry , 59 :2612 , 2016 |
| Abstract : |
| PubMedSearch : Brindisi_2016_J.Med.Chem_59_2612 |
| PubMedID: 26888301 |
| Title : Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents - Montanari_2016_J.Med.Chem_59_6387 |
| Author(s) : Montanari S , Scalvini L , Bartolini M , Belluti F , Gobbi S , Andrisano V , Ligresti A , Di Marzo V , Rivara S , Mor M , Bisi A , Rampa A |
| Ref : Journal of Medicinal Chemistry , 59 :6387 , 2016 |
| Abstract : |
| PubMedSearch : Montanari_2016_J.Med.Chem_59_6387 |
| PubMedID: 27309570 |
| Title : Genetic deletion of monoacylglycerol lipase leads to impaired cannabinoid receptor CB1 R signaling and anxiety-like behavior - Imperatore_2015_J.Neurochem_135_799 |
| Author(s) : Imperatore R , Morello G , Luongo L , Taschler U , Romano R , De Gregorio D , Belardo C , Maione S , Di Marzo V , Cristino L |
| Ref : Journal of Neurochemistry , 135 :799 , 2015 |
| Abstract : |
| PubMedSearch : Imperatore_2015_J.Neurochem_135_799 |
| PubMedID: 26223500 |
| Title : Inhibiting endocannabinoid biosynthesis: a novel approach to the treatment of constipation - Bashashati_2015_Br.J.Pharmacol_172_3099 |
| Author(s) : Bashashati M , Nasser Y , Keenan CM , Ho W , Piscitelli F , Nalli M , Mackie K , Storr MA , Di Marzo V , Sharkey KA |
| Ref : British Journal of Pharmacology , 172 :3099 , 2015 |
| Abstract : |
| PubMedSearch : Bashashati_2015_Br.J.Pharmacol_172_3099 |
| PubMedID: 25684407 |
| Title : Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons - Baggelaar_2015_J.Am.Chem.Soc_137_8851 |
| Author(s) : Baggelaar MP , Chameau PJ , Kantae V , Hummel J , Hsu KL , Janssen F , van der Wel T , Soethoudt M , Deng H , den Dulk H , Allara M , Florea BI , Di Marzo V , Wadman WJ , Kruse CG , Overkleeft HS , Hankemeier T , Werkman TR , Cravatt BF , van der Stelt M |
| Ref : Journal of the American Chemical Society , 137 :8851 , 2015 |
| Abstract : |
| PubMedSearch : Baggelaar_2015_J.Am.Chem.Soc_137_8851 |
| PubMedID: 26083464 |
| Gene_locus related to this paper: human-DAGLA , human-DAGLB |
| Title : The endocannabinoid system mediates aerobic exercise-induced antinociception in rats - Galdino_2014_Neuropharmacol_77_313 |
| Author(s) : Galdino G , Romero TR , Silva JF , Aguiar DC , de Paula AM , Cruz JS , Parrella C , Piscitelli F , Duarte ID , Di Marzo V , Perez AC |
| Ref : Neuropharmacology , 77 :313 , 2014 |
| Abstract : |
| PubMedSearch : Galdino_2014_Neuropharmacol_77_313 |
| PubMedID: 24148812 |
| Title : Discovery of Glycine Sulfonamides as Dual Inhibitors of sn-1-Diacylglycerol Lipase alpha and alpha\/beta-Hydrolase Domain 6 - Janssen_2014_J.Med.Chem_57_6610 |
| Author(s) : Janssen FJ , Deng H , Baggelaar MP , Allara M , van der Wel T , den Dulk H , Ligresti A , van Esbroeck AC , McGuire R , Di Marzo V , Overkleeft HS , van der Stelt M |
| Ref : Journal of Medicinal Chemistry , 57 :6610 , 2014 |
| Abstract : |
| PubMedSearch : Janssen_2014_J.Med.Chem_57_6610 |
| PubMedID: 24988361 |
| Title : Biaryl tetrazolyl ureas as inhibitors of endocannabinoid metabolism: modulation at the N-portion and distal phenyl ring - Ortar_2013_Eur.J.Med.Chem_63_118 |
| Author(s) : Ortar G , Morera E , De Petrocellis L , Ligresti A , Schiano Moriello A , Morera L , Nalli M , Ragno R , Pirolli A , Di Marzo V |
| Ref : Eur Journal of Medicinal Chemistry , 63 :118 , 2013 |
| Abstract : |
| PubMedSearch : Ortar_2013_Eur.J.Med.Chem_63_118 |
| PubMedID: 23474898 |
| Title : Acute inhibition of diacylglycerol lipase blocks endocannabinoid-mediated retrograde signalling: evidence for on-demand biosynthesis of 2-arachidonoylglycerol - Hashimotodani_2013_J.Physiol_591_4765 |
| Author(s) : Hashimotodani Y , Ohno-Shosaku T , Tanimura A , Kita Y , Sano Y , Shimizu T , Di Marzo V , Kano M |
| Ref : The Journal of Physiology , 591 :4765 , 2013 |
| Abstract : |
| PubMedSearch : Hashimotodani_2013_J.Physiol_591_4765 |
| PubMedID: 23858009 |
| Gene_locus related to this paper: human-DAGLA |
| Title : A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects - Bisogno_2013_Br.J.Pharmacol_169_784 |
| Author(s) : Bisogno T , Mahadevan A , Coccurello R , Chang JW , Allara M , Chen Y , Giacovazzo G , Lichtman A , Cravatt BF , Moles A , Di Marzo V |
| Ref : British Journal of Pharmacology , 169 :784 , 2013 |
| Abstract : |
| PubMedSearch : Bisogno_2013_Br.J.Pharmacol_169_784 |
| PubMedID: 23072382 |
| Gene_locus related to this paper: human-DAGLA , human-DAGLB |
| Title : Development of an activity-based probe and in silico design reveal highly selective inhibitors for diacylglycerol lipase-alpha in brain - |
| Author(s) : Baggelaar MP , Janssen FJ , van Esbroeck AC , den Dulk H , Allara M , Hoogendoorn S , McGuire R , Florea BI , Meeuwenoord N , van den Elst H , van der Marel GA , Brouwer J , Di Marzo V , Overkleeft HS , van der Stelt M |
| Ref : Angew Chem Int Ed Engl , 52 :12081 , 2013 |
| PubMedID: 24173880 |
| Gene_locus related to this paper: human-DAGLA |
| Title : The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG - Valdeolivas_2013_Cell.Death.Dis_4_e862 |
| Author(s) : Valdeolivas S , Pazos MR , Bisogno T , Piscitelli F , Iannotti FA , Allara M , Sagredo O , Di Marzo V , Fernandez-Ruiz J |
| Ref : Cell Death Dis , 4 :e862 , 2013 |
| Abstract : |
| PubMedSearch : Valdeolivas_2013_Cell.Death.Dis_4_e862 |
| PubMedID: 24136226 |
| Title : The First Dual ChE\/FAAH Inhibitors: New Perspectives for Alzheimer's Disease? - Rampa_2012_ACS.Med.Chem.Lett_3_182 |
| Author(s) : Rampa A , Bartolini M , Bisi A , Belluti F , Gobbi S , Andrisano V , Ligresti A , Di Marzo V |
| Ref : ACS Med Chem Lett , 3 :182 , 2012 |
| Abstract : |
| PubMedSearch : Rampa_2012_ACS.Med.Chem.Lett_3_182 |
| PubMedID: 24900454 |
| Title : Endocannabinoids generated by Ca2+ or by metabotropic glutamate receptors appear to arise from different pools of diacylglycerol lipase - Zhang_2011_PLoS.One_6_e16305 |
| Author(s) : Zhang L , Wang M , Bisogno T , Di Marzo V , Alger BE |
| Ref : PLoS ONE , 6 :e16305 , 2011 |
| Abstract : |
| PubMedSearch : Zhang_2011_PLoS.One_6_e16305 |
| PubMedID: 21305054 |
| Title : Diacylglycerol lipase is not involved in depolarization-induced suppression of inhibition at unitary inhibitory connections in mouse hippocampus - Min_2010_J.Neurosci_30_2710 |
| Author(s) : Min R , Testa-Silva G , Heistek TS , Canto CB , Lodder JC , Bisogno T , Di Marzo V , Brussaard AB , Burnashev N , Mansvelder HD |
| Ref : Journal of Neuroscience , 30 :2710 , 2010 |
| Abstract : |
| PubMedSearch : Min_2010_J.Neurosci_30_2710 |
| PubMedID: 20164355 |
| Title : FAAH and MAGL inhibitors: therapeutic opportunities from regulating endocannabinoid levels - Petrosino_2010_Curr.Opin.Investig.Drugs_11_51 |
| Author(s) : Petrosino S , Di Marzo V |
| Ref : Curr Opin Investig Drugs , 11 :51 , 2010 |
| Abstract : |
| PubMedSearch : Petrosino_2010_Curr.Opin.Investig.Drugs_11_51 |
| PubMedID: 20047159 |
| Title : DAG lipase involvement in depolarization-induced suppression of inhibition: does endocannabinoid biosynthesis always meet the demand? - Min_2010_Neuroscientist_16_608 |
| Author(s) : Min R , Di Marzo V , Mansvelder HD |
| Ref : Neuroscientist , 16 :608 , 2010 |
| Abstract : |
| PubMedSearch : Min_2010_Neuroscientist_16_608 |
| PubMedID: 20837870 |
| Title : Development of a potent inhibitor of 2-arachidonoylglycerol hydrolysis with antinociceptive activity in vivo - Bisogno_2009_Biochim.Biophys.Acta_1791_53 |
| Author(s) : Bisogno T , Ortar G , Petrosino S , Morera E , Palazzo E , Nalli M , Maione S , Di Marzo V |
| Ref : Biochimica & Biophysica Acta , 1791 :53 , 2009 |
| Abstract : |
| PubMedSearch : Bisogno_2009_Biochim.Biophys.Acta_1791_53 |
| PubMedID: 19027877 |
| Gene_locus related to this paper: human-DAGLA , human-DAGLB |
| Title : Tetrahydrolipstatin analogues as modulators of endocannabinoid 2-arachidonoylglycerol metabolism - Ortar_2008_J.Med.Chem_51_6970 |
| Author(s) : Ortar G , Bisogno T , Ligresti A , Morera E , Nalli M , Di Marzo V |
| Ref : Journal of Medicinal Chemistry , 51 :6970 , 2008 |
| Abstract : |
| PubMedSearch : Ortar_2008_J.Med.Chem_51_6970 |
| PubMedID: 18831576 |
| Title : Endocannabinoid dysregulation in the pancreas and adipose tissue of mice fed with a high-fat diet - Starowicz_2008_Obesity.(Silver.Spring)_16_553 |
| Author(s) : Starowicz KM , Cristino L , Matias I , Capasso R , Racioppi A , Izzo AA , Di Marzo V |
| Ref : Obesity (Silver Spring) , 16 :553 , 2008 |
| Abstract : |
| PubMedSearch : Starowicz_2008_Obesity.(Silver.Spring)_16_553 |
| PubMedID: 18239598 |
| Title : Study of the regulation of the endocannabinoid system in a virus model of multiple sclerosis reveals a therapeutic effect of palmitoylethanolamide - Loria_2008_Eur.J.Neurosci_28_633 |
| Author(s) : Loria F , Petrosino S , Mestre L , Spagnolo A , Correa F , Hernangomez M , Guaza C , Di Marzo V , Docagne F |
| Ref : European Journal of Neuroscience , 28 :633 , 2008 |
| Abstract : |
| PubMedSearch : Loria_2008_Eur.J.Neurosci_28_633 |
| PubMedID: 18657182 |
| Title : Antinociceptive effects of tetrazole inhibitors of endocannabinoid inactivation: cannabinoid and non-cannabinoid receptor-mediated mechanisms - Maione_2008_Br.J.Pharmacol_155_775 |
| Author(s) : Maione S , Morera E , Marabese I , Ligresti A , Luongo L , Ortar G , Di Marzo V |
| Ref : British Journal of Pharmacology , 155 :775 , 2008 |
| Abstract : |
| PubMedSearch : Maione_2008_Br.J.Pharmacol_155_775 |
| PubMedID: 18660824 |
| Title : Development of the first potent and specific inhibitors of endocannabinoid biosynthesis - Bisogno_2006_Biochim.Biophys.Acta_1761_205 |
| Author(s) : Bisogno T , Cascio MG , Saha B , Mahadevan A , Urbani P , Minassi A , Appendino G , Saturnino C , Martin B , Razdan R , Di Marzo V |
| Ref : Biochimica & Biophysica Acta , 1761 :205 , 2006 |
| Abstract : |
| PubMedSearch : Bisogno_2006_Biochim.Biophys.Acta_1761_205 |
| PubMedID: 16466961 |
| Gene_locus related to this paper: human-DAGLA , human-DAGLB |
| Title : Endocannabinoid metabolic pathways and enzymes - Ligresti_2005_Curr.Drug.Targets.CNS.Neurol.Disord_4_615 |
| Author(s) : Ligresti A , Cascio MG , Di Marzo V |
| Ref : Curr Drug Targets CNS Neurol Disord , 4 :615 , 2005 |
| Abstract : |
| PubMedSearch : Ligresti_2005_Curr.Drug.Targets.CNS.Neurol.Disord_4_615 |
| PubMedID: 16375679 |
| Title : Differential diurnal variations of anandamide and 2-arachidonoyl-glycerol levels in rat brain - Valenti_2004_Cell.Mol.Life.Sci_61_945 |
| Author(s) : Valenti M , Vigano D , Casico MG , Rubino T , Steardo L , Parolaro D , Di Marzo V |
| Ref : Cell Mol Life Sciences , 61 :945 , 2004 |
| Abstract : |
| PubMedSearch : Valenti_2004_Cell.Mol.Life.Sci_61_945 |
| PubMedID: 15095014 |
| Title : Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain - Bisogno_2003_J.Cell.Biol_163_463 |
| Author(s) : Bisogno T , Howell F , Williams G , Minassi A , Cascio MG , Ligresti A , Matias I , Schiano-Moriello A , Paul P , Williams EJ , Gangadharan U , Hobbs C , Di Marzo V , Doherty P |
| Ref : Journal of Cell Biology , 163 :463 , 2003 |
| Abstract : |
| PubMedSearch : Bisogno_2003_J.Cell.Biol_163_463 |
| PubMedID: 14610053 |
| Gene_locus related to this paper: human-DAGLA , human-DAGLB , mouse-DGLB , mouse-q6wqj1 |
| Title : Highly selective CB(1) cannabinoid receptor ligands and novel CB(1)\/VR(1) vanilloid receptor hybrid ligands - Di Marzo_2001_Biochem.Biophys.Res.Commun_281_444 |
| Author(s) : Di Marzo V , Bisogno T , De Petrocellis L , Brandi I , Jefferson RG , Winckler RL , Davis JB , Dasse O , Mahadevan A , Razdan RK , Martin BR |
| Ref : Biochemical & Biophysical Research Communications , 281 :444 , 2001 |
| Abstract : |
| PubMedSearch : Di Marzo_2001_Biochem.Biophys.Res.Commun_281_444 |
| PubMedID: 11181068 |
| Title : Cannabinoid properties of methylfluorophosphonate analogs - Martin_2000_J.Pharmacol.Exp.Ther_294_1209 |
| Author(s) : Martin BR , Beletskaya I , Patrick G , Jefferson R , Winckler R , Deutsch DG , Di Marzo V , Dasse O , Mahadevan A , Razdan RK |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 294 :1209 , 2000 |
| Abstract : |
| PubMedSearch : Martin_2000_J.Pharmacol.Exp.Ther_294_1209 |
| PubMedID: 10945879 |