OTFP
compound 4 of Roe et al. 1997. IC50 (M) Trichoplusia ni JH esterase 3.1 109; Eel AChE 4.7 10-6; Trichoplusia ni 1-NAE 2.7 107
General
Type : Trifluoro, Halo ketone, Sulfur Compound
Chemical_Nomenclature : 1,1,1-trifluoro-3-octylsulfanylpropan-2-one
Canonical SMILES : CCCCCCCCSCC(=O)C(F)(F)F
InChI : InChI=1S\/C11H19F3OS\/c1-2-3-4-5-6-7-8-16-9-10(15)11(12,13)14\/h2-9H2,1H3
InChIKey : WMQHRXUKAYSPPK-UHFFFAOYSA-N
Other name(s) : TFC || CHEMBL89506 || 3-Octylthio-1,1,1-trifluoro-2-propanone || 2-Propanone,1,1,1-trifluoro-3-(octylthio)- || 1,1,1-trifluoro-3-(octylsulfanyl)propan-2-one || 1,1,1-trifluoro-3-(octylthio)acetone || 3-octylthio-1,1,1-trifluoropropan-2-one
MW : 256.32
Formula : C11H19F3OS
CAS_number : 89820-00-8
PubChem : 146089
UniChem : WMQHRXUKAYSPPK-UHFFFAOYSA-N
Target
Families : OTFP ligand of proteins in family
Juvenile_hormone_esterase
Cutinase
Structure :
2FJ0
Protein :
manse-jhest
monfr-CUT1
trini-jhestrp
References (27)
| Title : Transcriptomic Analysis of the Diamondback Moth Under Exposure to the Juvenile Hormone Esterase (JHE) Inhibitor 3-Octylthio-1,1,1-trifluoro-2-propanone (OTFP) - Wang_2025_Insects_16_1152 |
| Author(s) : Wang Y , Wang X , Lin Y , Zheng S , Qiu J , Gao J , Gu X , Huang J |
| Ref : Insects , 16 :1152 , 2025 |
| Abstract : |
| PubMedSearch : Wang_2025_Insects_16_1152 |
| PubMedID: 41302898 |
| Title : Transcriptomic Analysis of the Diamondback Moth Under Exposure to the Juvenile Hormone Esterase (JHE) Inhibitor 3-Octylthio-1,1,1-trifluoro-2-propanone (OTFP) - Wang_2025_Insects_16_1152 |
| Author(s) : Wang Y , Wang X , Lin Y , Zheng S , Qiu J , Gao J , Gu X , Huang J |
| Ref : Insects , 16 :1152 , 2025 |
| Abstract : |
| PubMedSearch : Wang_2025_Insects_16_1152 |
| PubMedID: 41302898 |
| Title : Transcriptomic Analysis of the Diamondback Moth Under Exposure to the Juvenile Hormone Esterase (JHE) Inhibitor 3-Octylthio-1,1,1-trifluoro-2-propanone (OTFP) - Wang_2025_Insects_16_1152 |
| Author(s) : Wang Y , Wang X , Lin Y , Zheng S , Qiu J , Gao J , Gu X , Huang J |
| Ref : Insects , 16 :1152 , 2025 |
| Abstract : |
| PubMedSearch : Wang_2025_Insects_16_1152 |
| PubMedID: 41302898 |
| Title : Structural studies of a potent insect maturation inhibitor bound to the juvenile hormone esterase of Manduca sexta - Wogulis_2006_Biochemistry_45_4045 |
| Author(s) : Wogulis M , Wheelock CE , Kamita SG , Hinton AC , Whetstone PA , Hammock BD , Wilson DK |
| Ref : Biochemistry , 45 :4045 , 2006 |
| Abstract : |
| PubMedSearch : Wogulis_2006_Biochemistry_45_4045 |
| PubMedID: 16566578 |
| Gene_locus related to this paper: manse-jhest |
| Title : Structural studies of a potent insect maturation inhibitor bound to the juvenile hormone esterase of Manduca sexta - Wogulis_2006_Biochemistry_45_4045 |
| Author(s) : Wogulis M , Wheelock CE , Kamita SG , Hinton AC , Whetstone PA , Hammock BD , Wilson DK |
| Ref : Biochemistry , 45 :4045 , 2006 |
| Abstract : |
| PubMedSearch : Wogulis_2006_Biochemistry_45_4045 |
| PubMedID: 16566578 |
| Gene_locus related to this paper: manse-jhest |
| Title : Structural studies of a potent insect maturation inhibitor bound to the juvenile hormone esterase of Manduca sexta - Wogulis_2006_Biochemistry_45_4045 |
| Author(s) : Wogulis M , Wheelock CE , Kamita SG , Hinton AC , Whetstone PA , Hammock BD , Wilson DK |
| Ref : Biochemistry , 45 :4045 , 2006 |
| Abstract : |
| PubMedSearch : Wogulis_2006_Biochemistry_45_4045 |
| PubMedID: 16566578 |
| Gene_locus related to this paper: manse-jhest |
| Title : In vitro expression and biochemical characterization of juvenile hormone esterase from Manduca sexta - Hinton_2003_Insect.Biochem.Mol.Biol_33_317 |
| Author(s) : Hinton AC , Hammock BD |
| Ref : Insect Biochemistry & Molecular Biology , 33 :317 , 2003 |
| Abstract : |
| PubMedSearch : Hinton_2003_Insect.Biochem.Mol.Biol_33_317 |
| PubMedID: 12609517 |
| Title : Juvenile hormone esterase (JHE) from Tenebrio molitor: full-length cDNA sequence, in vitro expression, and characterization of the recombinant protein - Hinton_2003_Insect.Biochem.Mol.Biol_33_477 |
| Author(s) : Hinton AC , Hammock BD |
| Ref : Insect Biochemistry & Molecular Biology , 33 :477 , 2003 |
| Abstract : |
| PubMedSearch : Hinton_2003_Insect.Biochem.Mol.Biol_33_477 |
| PubMedID: 12706627 |
| Gene_locus related to this paper: tenmo-Q8WRD8 |
| Title : Juvenile hormone esterase (JHE) from Tenebrio molitor: full-length cDNA sequence, in vitro expression, and characterization of the recombinant protein - Hinton_2003_Insect.Biochem.Mol.Biol_33_477 |
| Author(s) : Hinton AC , Hammock BD |
| Ref : Insect Biochemistry & Molecular Biology , 33 :477 , 2003 |
| Abstract : |
| PubMedSearch : Hinton_2003_Insect.Biochem.Mol.Biol_33_477 |
| PubMedID: 12706627 |
| Gene_locus related to this paper: tenmo-Q8WRD8 |
| Title : In vitro expression and biochemical characterization of juvenile hormone esterase from Manduca sexta - Hinton_2003_Insect.Biochem.Mol.Biol_33_317 |
| Author(s) : Hinton AC , Hammock BD |
| Ref : Insect Biochemistry & Molecular Biology , 33 :317 , 2003 |
| Abstract : |
| PubMedSearch : Hinton_2003_Insect.Biochem.Mol.Biol_33_317 |
| PubMedID: 12609517 |
| Title : Juvenile hormone esterase (JHE) from Tenebrio molitor: full-length cDNA sequence, in vitro expression, and characterization of the recombinant protein - Hinton_2003_Insect.Biochem.Mol.Biol_33_477 |
| Author(s) : Hinton AC , Hammock BD |
| Ref : Insect Biochemistry & Molecular Biology , 33 :477 , 2003 |
| Abstract : |
| PubMedSearch : Hinton_2003_Insect.Biochem.Mol.Biol_33_477 |
| PubMedID: 12706627 |
| Gene_locus related to this paper: tenmo-Q8WRD8 |
| Title : In vitro expression and biochemical characterization of juvenile hormone esterase from Manduca sexta - Hinton_2003_Insect.Biochem.Mol.Biol_33_317 |
| Author(s) : Hinton AC , Hammock BD |
| Ref : Insect Biochemistry & Molecular Biology , 33 :317 , 2003 |
| Abstract : |
| PubMedSearch : Hinton_2003_Insect.Biochem.Mol.Biol_33_317 |
| PubMedID: 12609517 |
| Title : Molecular cloning, characterization, and expression of a redox-responsive cutinase from Monilinia fructicola (Wint.) Honey - Wang_2002_Fungal.Genet.Biol_35_261 |
| Author(s) : Wang GY , Michailides TJ , Hammock BD , Lee YM , Bostock RM |
| Ref : Fungal Genet Biol , 35 :261 , 2002 |
| Abstract : |
| PubMedSearch : Wang_2002_Fungal.Genet.Biol_35_261 |
| PubMedID: 11929215 |
| Gene_locus related to this paper: monfr-CUT1 |
| Title : Molecular cloning, characterization, and expression of a redox-responsive cutinase from Monilinia fructicola (Wint.) Honey - Wang_2002_Fungal.Genet.Biol_35_261 |
| Author(s) : Wang GY , Michailides TJ , Hammock BD , Lee YM , Bostock RM |
| Ref : Fungal Genet Biol , 35 :261 , 2002 |
| Abstract : |
| PubMedSearch : Wang_2002_Fungal.Genet.Biol_35_261 |
| PubMedID: 11929215 |
| Gene_locus related to this paper: monfr-CUT1 |
| Title : Molecular cloning, characterization, and expression of a redox-responsive cutinase from Monilinia fructicola (Wint.) Honey - Wang_2002_Fungal.Genet.Biol_35_261 |
| Author(s) : Wang GY , Michailides TJ , Hammock BD , Lee YM , Bostock RM |
| Ref : Fungal Genet Biol , 35 :261 , 2002 |
| Abstract : |
| PubMedSearch : Wang_2002_Fungal.Genet.Biol_35_261 |
| PubMedID: 11929215 |
| Gene_locus related to this paper: monfr-CUT1 |
| Title : Synthesis of new carboxylesterase inhibitors and evaluation of potency and water solubility - Wheelock_2001_Chem.Res.Toxicol_14_1563 |
| Author(s) : Wheelock CE , Severson TF , Hammock BD |
| Ref : Chemical Research in Toxicology , 14 :1563 , 2001 |
| Abstract : |
| PubMedSearch : Wheelock_2001_Chem.Res.Toxicol_14_1563 |
| PubMedID: 11743738 |
| Title : Synthesis of new carboxylesterase inhibitors and evaluation of potency and water solubility - Wheelock_2001_Chem.Res.Toxicol_14_1563 |
| Author(s) : Wheelock CE , Severson TF , Hammock BD |
| Ref : Chemical Research in Toxicology , 14 :1563 , 2001 |
| Abstract : |
| PubMedSearch : Wheelock_2001_Chem.Res.Toxicol_14_1563 |
| PubMedID: 11743738 |
| Title : Synthesis of new carboxylesterase inhibitors and evaluation of potency and water solubility - Wheelock_2001_Chem.Res.Toxicol_14_1563 |
| Author(s) : Wheelock CE , Severson TF , Hammock BD |
| Ref : Chemical Research in Toxicology , 14 :1563 , 2001 |
| Abstract : |
| PubMedSearch : Wheelock_2001_Chem.Res.Toxicol_14_1563 |
| PubMedID: 11743738 |
| Title : Affinity purification and characterization of a cutinase from the fungal plant pathogen Monilinia fructicola (Wint.) honey - Wang_2000_Arch.Biochem.Biophys_382_31 |
| Author(s) : Wang GY , Michailides TJ , Hammock BD , Lee YM , Bostock RM |
| Ref : Archives of Biochemistry & Biophysics , 382 :31 , 2000 |
| Abstract : |
| PubMedSearch : Wang_2000_Arch.Biochem.Biophys_382_31 |
| PubMedID: 11051094 |
| Gene_locus related to this paper: monfr-CUT1 |
| Title : Affinity purification and characterization of a cutinase from the fungal plant pathogen Monilinia fructicola (Wint.) honey - Wang_2000_Arch.Biochem.Biophys_382_31 |
| Author(s) : Wang GY , Michailides TJ , Hammock BD , Lee YM , Bostock RM |
| Ref : Archives of Biochemistry & Biophysics , 382 :31 , 2000 |
| Abstract : |
| PubMedSearch : Wang_2000_Arch.Biochem.Biophys_382_31 |
| PubMedID: 11051094 |
| Gene_locus related to this paper: monfr-CUT1 |
| Title : Affinity purification and characterization of a cutinase from the fungal plant pathogen Monilinia fructicola (Wint.) honey - Wang_2000_Arch.Biochem.Biophys_382_31 |
| Author(s) : Wang GY , Michailides TJ , Hammock BD , Lee YM , Bostock RM |
| Ref : Archives of Biochemistry & Biophysics , 382 :31 , 2000 |
| Abstract : |
| PubMedSearch : Wang_2000_Arch.Biochem.Biophys_382_31 |
| PubMedID: 11051094 |
| Gene_locus related to this paper: monfr-CUT1 |
| Title : A novel geminal diol as a highly specific and stable in vivo inhibitor of insect juvenile hormone esterase - Roe_1997_Arch.Insect.Biochem.Physiol_36_165 |
| Author(s) : Roe, R.M , Anspaugh DD , Venkatesh K , Linderman RJ , Graves DM |
| Ref : Archives of Insect Biochemistry & Physiology , 36 :165 , 1997 |
| Abstract : |
| PubMedSearch : Roe_1997_Arch.Insect.Biochem.Physiol_36_165 |
| PubMedID: |
| Title : A novel geminal diol as a highly specific and stable in vivo inhibitor of insect juvenile hormone esterase - Roe_1997_Arch.Insect.Biochem.Physiol_36_165 |
| Author(s) : Roe, R.M , Anspaugh DD , Venkatesh K , Linderman RJ , Graves DM |
| Ref : Archives of Insect Biochemistry & Physiology , 36 :165 , 1997 |
| Abstract : |
| PubMedSearch : Roe_1997_Arch.Insect.Biochem.Physiol_36_165 |
| PubMedID: |
| Title : A novel geminal diol as a highly specific and stable in vivo inhibitor of insect juvenile hormone esterase - Roe_1997_Arch.Insect.Biochem.Physiol_36_165 |
| Author(s) : Roe, R.M , Anspaugh DD , Venkatesh K , Linderman RJ , Graves DM |
| Ref : Archives of Insect Biochemistry & Physiology , 36 :165 , 1997 |
| Abstract : |
| PubMedSearch : Roe_1997_Arch.Insect.Biochem.Physiol_36_165 |
| PubMedID: |
| Title : Substituted thiotrifluoropropanones as potent selective inhibitors of juvenile hormone esterase - Hammock_1984_Pestic.Biochem.Physiol_22_209 |
| Author(s) : Hammock BD , Abdel-Aalab YAI , Mullin CA , Hanzlik TN , Roe RM |
| Ref : Pestic Biochem Physiol , 22 :209 , 1984 |
| Abstract : |
| PubMedSearch : Hammock_1984_Pestic.Biochem.Physiol_22_209 |
| PubMedID: |
| Title : Substituted thiotrifluoropropanones as potent selective inhibitors of juvenile hormone esterase - Hammock_1984_Pestic.Biochem.Physiol_22_209 |
| Author(s) : Hammock BD , Abdel-Aalab YAI , Mullin CA , Hanzlik TN , Roe RM |
| Ref : Pestic Biochem Physiol , 22 :209 , 1984 |
| Abstract : |
| PubMedSearch : Hammock_1984_Pestic.Biochem.Physiol_22_209 |
| PubMedID: |
| Title : Substituted thiotrifluoropropanones as potent selective inhibitors of juvenile hormone esterase - Hammock_1984_Pestic.Biochem.Physiol_22_209 |
| Author(s) : Hammock BD , Abdel-Aalab YAI , Mullin CA , Hanzlik TN , Roe RM |
| Ref : Pestic Biochem Physiol , 22 :209 , 1984 |
| Abstract : |
| PubMedSearch : Hammock_1984_Pestic.Biochem.Physiol_22_209 |
| PubMedID: |