This family corresponds to the Carbohydrate Esterase family CE5 in CAZy - Carbohydrate-Active enZYmes database (CE_5). (from interpro) Aerial plant organs are protected by a cuticle composed of an insoluble polymeric structural compound, cutin, which is a polyester composed of hydroxy and hydroxyepoxy fatty acids. Plant pathogenic fungi produce extracellular degradative enzymes that play an important role in pathogenesis. They include cutinase, which hydrolyses cutin, facilitating fungus penetration through the cuticle. Inhibition of the enzyme can prevent fungal infection through intact cuticles. Cutin monomers released from the cuticle by small amounts of cutinase on fungal spore surfaces can greatly increase the amount of cutinase secreted by the spore, the mechanism for which process is as yet unknown. It is shown by Masaki et al. that some Cutinase-Like enzyme hydrolyzes polylactic acid and other biodegradable plastics. This family differs substantially from the Polyesterase-lipase-cutinase family. Here bacterial and fungal enzymes important in plant pathogenicity
Interpro : IPR011150 Cutinase, monofunctional Cutinase_monf , IPR000675 Cutinase\/acetylxylan esterase Cutinase\/axe
PIRSF : No PIRSF
Pdoc : PDOC00140
Pfam : PF01083 Cutinase
Prints : PR00129
EC Number : 3.1.1.74
Structures (65)
Genes Proteins in Cutinase family (562)
Fragments of genes in Cutinase family (16)
Structures in Cutinase family (65)Substrates in Cutinase family (33)
Inhibitors in Cutinase family (34)
Title : Structural and functional studies of a Fusarium oxysporum cutinase with polyethylene terephthalate modification potential - Dimarogona_2015_Biochim.Biophys.Acta_1850_2308 |
Author(s) : Dimarogona M , Nikolaivits E , Kanelli M , Christakopoulos P , Sandgren M , Topakas E |
Ref : Biochimica & Biophysica Acta , 1850 :2308 , 2015 |
Abstract : Dimarogona_2015_Biochim.Biophys.Acta_1850_2308 |
ESTHER : Dimarogona_2015_Biochim.Biophys.Acta_1850_2308 |
PubMedSearch : Dimarogona_2015_Biochim.Biophys.Acta_1850_2308 |
PubMedID: 26291558 |
Gene_locus related to this paper: fusox-CUT |
Title : A Cutinase from Trichoderma reesei with a Lid-Covered Active Site and Kinetic Properties of True Lipases - Roussel_2014_J.Mol.Biol_426_3757 |
Author(s) : Roussel A , Amara S , Nyyssola A , Mateos-Diaz E , Blangy S , Kontkanen H , Westerholm-Parvinen A , Carriere F , Cambillau C |
Ref : Journal of Molecular Biology , 426 :3757 , 2014 |
Abstract : Roussel_2014_J.Mol.Biol_426_3757 |
ESTHER : Roussel_2014_J.Mol.Biol_426_3757 |
PubMedSearch : Roussel_2014_J.Mol.Biol_426_3757 |
PubMedID: 25219509 |
Gene_locus related to this paper: hypjq-g0rh85 |
Title : Thermodynamic and structural investigation of the specific SDS binding of humicola insolens cutinase - Kold_2014_Protein.Sci_23_1023 |
Author(s) : Kold D , Dauter Z , Laustsen AK , Brzozowski AM , Turkenburg JP , Nielsen AD , Koldso H , Petersen E , Schiott B , De Maria L , Wilson KS , Svendsen A , Wimmer R |
Ref : Protein Science , 23 :1023 , 2014 |
Abstract : Kold_2014_Protein.Sci_23_1023 |
ESTHER : Kold_2014_Protein.Sci_23_1023 |
PubMedSearch : Kold_2014_Protein.Sci_23_1023 |
PubMedID: 24832484 |
Gene_locus related to this paper: humin-cut |
Title : Tetrahydrolipstatin inhibition, functional analyses, and three-dimensional structure of a lipase essential for mycobacterial viability - Crellin_2010_J.Biol.Chem_285_30050 |
Author(s) : Crellin PK , Vivian JP , Scoble J , Chow FM , West NP , Brammananth R , Proellocks NI , Shahine A , Le Nours J , Wilce MC , Britton WJ , Coppel RL , Rossjohn J , Beddoe T |
Ref : Journal of Biological Chemistry , 285 :30050 , 2010 |
Abstract : Crellin_2010_J.Biol.Chem_285_30050 |
ESTHER : Crellin_2010_J.Biol.Chem_285_30050 |
PubMedSearch : Crellin_2010_J.Biol.Chem_285_30050 |
PubMedID: 20656688 |
Gene_locus related to this paper: mycs2-a0r619 |
Title : Mycobacteriophage Lysin B is a novel mycolylarabinogalactan esterase - Payne_2009_Mol.Microbiol_73_367 |
Author(s) : Payne K , Sun Q , Sacchettini J , Hatfull GF |
Ref : Molecular Microbiology , 73 :367 , 2009 |
Abstract : Payne_2009_Mol.Microbiol_73_367 |
ESTHER : Payne_2009_Mol.Microbiol_73_367 |
PubMedSearch : Payne_2009_Mol.Microbiol_73_367 |
PubMedID: 19555454 |
Gene_locus related to this paper: bpmd2-vg12 |
Title : Catalysis by Glomerella cingulata cutinase requires conformational cycling between the active and inactive states of its catalytic triad - Nyon_2009_J.Mol.Biol_385_226 |
Author(s) : Nyon MP , Rice DW , Berrisford JM , Hounslow AM , Moir AJ , Huang H , Nathan S , Mahadi NM , Bakar FD , Craven CJ |
Ref : Journal of Molecular Biology , 385 :226 , 2009 |
Abstract : Nyon_2009_J.Mol.Biol_385_226 |
ESTHER : Nyon_2009_J.Mol.Biol_385_226 |
PubMedSearch : Nyon_2009_J.Mol.Biol_385_226 |
PubMedID: 18983850 |
Gene_locus related to this paper: colgl-cutas |
Title : Solid-state structural characterization of cutinase-ECE-pincer-metal hybrids - Rutten_2009_Chemistry_15_4270 |
Author(s) : Rutten L , Wieczorek B , Mannie JP , Kruithof CA , Dijkstra HP , Egmond MR , Lutz M , Klein Gebbink RJ , Gros P , van Koten G |
Ref : Chemistry , 15 :4270 , 2009 |
Abstract : Rutten_2009_Chemistry_15_4270 |
ESTHER : Rutten_2009_Chemistry_15_4270 |
PubMedSearch : Rutten_2009_Chemistry_15_4270 |
PubMedID: 19219875 |
Gene_locus related to this paper: fusso-cutas |
Title : Structural and functional studies of Aspergillus oryzae cutinase: enhanced thermostability and hydrolytic activity of synthetic ester and polyester degradation - Liu_2009_J.Am.Chem.Soc_131_15711 |
Author(s) : Liu Z , Gosser Y , Baker PJ , Ravee Y , Lu Z , Alemu G , Li H , Butterfoss GL , Kong XP , Gross R , Montclare JK |
Ref : Journal of the American Chemical Society , 131 :15711 , 2009 |
Abstract : Liu_2009_J.Am.Chem.Soc_131_15711 |
ESTHER : Liu_2009_J.Am.Chem.Soc_131_15711 |
PubMedSearch : Liu_2009_J.Am.Chem.Soc_131_15711 |
PubMedID: 19810726 |
Gene_locus related to this paper: aspor-cutas |
Title : Crystal structure and enhanced activity of a cutinase-like enzyme from Cryptococcus sp. strain S-2 - Kodama_2009_Proteins_77_710 |
Author(s) : Kodama Y , Masaki K , Kondo H , Suzuki M , Tsuda S , Nagura T , Shimba N , Suzuki E , Iefuji H |
Ref : Proteins , 77 :710 , 2009 |
Abstract : Kodama_2009_Proteins_77_710 |
ESTHER : Kodama_2009_Proteins_77_710 |
PubMedSearch : Kodama_2009_Proteins_77_710 |
PubMedID: 19544571 |
Gene_locus related to this paper: crysp-Q874E9 |
Title : Lipase active-site-directed anchoring of organometallics: metallopincer\/protein hybrids - Kruithof_2005_Chemistry_11_6869 |
Author(s) : Kruithof CA , Casado MA , Guillena G , Egmond MR , van der Kerk-van Hoof A , Heck AJ , Klein Gebbink RJ , van Koten G |
Ref : Chemistry , 11 :6869 , 2005 |
Abstract : Kruithof_2005_Chemistry_11_6869 |
ESTHER : Kruithof_2005_Chemistry_11_6869 |
PubMedSearch : Kruithof_2005_Chemistry_11_6869 |
PubMedID: 16224766 |
Gene_locus related to this paper: fusso-cutas |
Title : Cutinase-like enzyme from the yeast Cryptococcus sp. strain S-2 hydrolyzes polylactic acid and other biodegradable plastics - Masaki_2005_Appl.Environ.Microbiol_71_7548 |
Author(s) : Masaki K , Kamini NR , Ikeda H , Iefuji H |
Ref : Applied Environmental Microbiology , 71 :7548 , 2005 |
Abstract : Masaki_2005_Appl.Environ.Microbiol_71_7548 |
ESTHER : Masaki_2005_Appl.Environ.Microbiol_71_7548 |
PubMedSearch : Masaki_2005_Appl.Environ.Microbiol_71_7548 |
PubMedID: 16269800 |
Gene_locus related to this paper: crysp-Q874E9 |
Title : Genome structure of mycobacteriophage D29: implications for phage evolution - Ford_1998_J.Mol.Biol_279_143 |
Author(s) : Ford ME , Sarkis GJ , Belanger AE , Hendrix RW , Hatfull GF |
Ref : Journal of Molecular Biology , 279 :143 , 1998 |
Abstract : Ford_1998_J.Mol.Biol_279_143 |
ESTHER : Ford_1998_J.Mol.Biol_279_143 |
PubMedSearch : Ford_1998_J.Mol.Biol_279_143 |
PubMedID: 9636706 |
Gene_locus related to this paper: bpmd2-vg12 , bpmdd-prxh |
Title : Crystal structure of cutinase covalently inhibited by a triglyceride analogue - Longhi_1997_Protein.Sci_6_275 |
Author(s) : Longhi S , Mannesse M , Verheij HM , De Haas GH , Egmond M , Knoops-Mouthuy E , Cambillau C |
Ref : Protein Science , 6 :275 , 1997 |
Abstract : Longhi_1997_Protein.Sci_6_275 |
ESTHER : Longhi_1997_Protein.Sci_6_275 |
PubMedSearch : Longhi_1997_Protein.Sci_6_275 |
PubMedID: 9041628 |
Gene_locus related to this paper: fusso-cutas |
Title : Dynamics of Fusarium solani cutinase investigated through structural comparison among different crystal forms of its variants - Longhi_1996_Proteins_26_442 |
Author(s) : Longhi S , Nicolas A , Creveld L , Egmond M , Verrips CT , de Vlieg J , Martinez C , Cambillau C |
Ref : Proteins , 26 :442 , 1996 |
Abstract : Longhi_1996_Proteins_26_442 |
ESTHER : Longhi_1996_Proteins_26_442 |
PubMedSearch : Longhi_1996_Proteins_26_442 |
PubMedID: 8990497 |
Gene_locus related to this paper: fusso-cutas |
Title : Cutinase, a lipolytic enzyme with a preformed oxyanion hole - Martinez_1994_Biochemistry_33_83 |
Author(s) : Martinez C , Nicolas A , van Tilbeurgh H , Egloff MP , Cudrey C , Verger R , Cambillau C |
Ref : Biochemistry , 33 :83 , 1994 |
Abstract : Martinez_1994_Biochemistry_33_83 |
ESTHER : Martinez_1994_Biochemistry_33_83 |
PubMedSearch : Martinez_1994_Biochemistry_33_83 |
PubMedID: 8286366 |
Gene_locus related to this paper: fusso-cutas , orysa-LPL1 |
Title : Cloning and analysis of CUT1, a cutinase gene from Magnaporthe grisea - Sweigard_1992_Mol.Gen.Genet_232_174 |
Author(s) : Sweigard JA , Chumley FG , Valent B |
Ref : Molecular & General Genetics , 232 :174 , 1992 |
Abstract : Sweigard_1992_Mol.Gen.Genet_232_174 |
ESTHER : Sweigard_1992_Mol.Gen.Genet_232_174 |
PubMedSearch : Sweigard_1992_Mol.Gen.Genet_232_174 |
PubMedID: 1557023 |
Gene_locus related to this paper: maggr-cutas |
Title : Fusarium solani cutinase is a lipolytic enzyme with a catalytic serine accessible to solvent - Martinez_1992_Nature_356_615 |
Author(s) : Martinez C , de Geus P , Lauwereys M , Matthyssens G , Cambillau C |
Ref : Nature , 356 :615 , 1992 |
Abstract : Martinez_1992_Nature_356_615 |
ESTHER : Martinez_1992_Nature_356_615 |
PubMedSearch : Martinez_1992_Nature_356_615 |
PubMedID: 1560844 |
Gene_locus related to this paper: fusso-cutas , orysa-LPL1 |
Title : Structure of cutinase gene, cDNA, and the derived amino acid sequence from phytopathogenic fungi - Ettinger_1987_Biochemistry_26_7883 |
Author(s) : Ettinger WF , Thukral SK , Kolattukudy PE |
Ref : Biochemistry , 26 :7883 , 1987 |
Abstract : Ettinger_1987_Biochemistry_26_7883 |
ESTHER : Ettinger_1987_Biochemistry_26_7883 |
PubMedSearch : Ettinger_1987_Biochemistry_26_7883 |
PubMedID: |
Gene_locus related to this paper: colca-cutas , colgl-cutas |