Family: Juvenile_hormone_esterase

Block: C

Parent Family: Carboxylesterase


Juvenile hormone JH is an insect hormone containing an alpha,beta-unsaturated ester consisting of a small alcohol and long hydrophobic acid. JH degradation is required for proper insect development. One pathway of this degradation is through juvenile hormone esterase JHE which cleaves the JH ester bond to produce methanol and JH acid. Another way of degradation of JH is epoxyde hydrolysis. Most insect species contain only juvenile hormone (JH) III. To date JH 0, JH I, and JH II have been identified only in the Lepidoptera (butterflies and moths). The form JHB3 (JH III bisepoxide) appears to be the most important JH in the Diptera, or flies. Certain species of crustaceans have been shown to produce and secrete methyl farnesoate, which is juvenile hormone III lacking the epoxide group. Methyl farnesoate is believed to play a role similar to that of JH in crustaceans. In drosophila DmJHE is the hormone esterase with precise regulation and highly specific activity for its substrate, juvenile hormone. DmJHEdup is an odorant degrading esterase (ODE) responsible for processing various kairomones in antennae


Interpro : IPR002018 Carboxylesterase, type B

PIRSF : PIRSF005676 COesterase

Pdoc : No Pdoc

Pfam : PF00135 COesterase

Prints : No Print

EC Number :


Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (1)

Genes Proteins in Juvenile_hormone_esterase family (124)

Fragments of genes in Juvenile_hormone_esterase family (40)

Structures in Juvenile_hormone_esterase family (1)

Substrates in Juvenile_hormone_esterase family (4)

Inhibitors in Juvenile_hormone_esterase family (6)

References (3)

Title : The molecular basis for the neofunctionalization of the juvenile hormone esterase duplication in Drosophila - Hopkins_2019_Insect.Biochem.Mol.Biol_106_10
Author(s) : Hopkins DH , Rane RV , Younus F , Coppin CW , Pandey G , Jackson CJ , Oakeshott JG
Ref : Insect Biochemistry & Molecular Biology , 106 :10 , 2019
PubMedID: 30611903
Gene_locus related to this paper: drome-CG8424 , drome-CG8425

Title : Juvenile hormone esterase: biochemistry and structure - Kamita_2010_J.Pestic.Sci_35_265
Author(s) : Kamita SG , Hammock BD
Ref : Journal of Pesticide Science , 35 :265 , 2010
PubMedID: 23543805

Title : Structural studies of a potent insect maturation inhibitor bound to the juvenile hormone esterase of Manduca sexta - Wogulis_2006_Biochemistry_45_4045
Author(s) : Wogulis M , Wheelock CE , Kamita SG , Hinton AC , Whetstone PA , Hammock BD , Wilson DK
Ref : Biochemistry , 45 :4045 , 2006
PubMedID: 16566578
Gene_locus related to this paper: manse-jhest