Phenolidene-dimethoxy-inden-CpdB7
human-CES2 IC50 0.11 +/- 0.02 microM
General
Type : Derivative of Donepezil, Indole, Inden
Chemical_Nomenclature : 2-phenolidene-5,6-dimethoxy-3H-inden-1-one
Canonical SMILES : C1(=C(C=C2C(=C1)C(C(C2)=CC3=CC=CC=C3O)=O)OC)OC
InChI : InChI=1S\/C18H16O4\/c1-21-16-9-12-8-13(7-11-5-3-4-6-15(11)19)18(20)14(12)10-17(16)22-2\/h3-7,9-10,19H,8H2,1-2H3
InChIKey : CTWKMRAEVXYMNU-UHFFFAOYSA-N
Other name(s) : Compound B7
Target
Families : Phenolidene-dimethoxy-inden-CpdB7 ligand of proteins in family
Carb_B_Chordata
Protein :
human-CES2
References (1)
| Title : Discovery of orally active and serine-targeting covalent inhibitors against hCES2A for ameliorating irinotecan-triggered gut toxicity - Zhang_2025_Acta.Pharm.Sin.B_15_5312 |
| Author(s) : Zhang Y , Fan Y , Song Y , Zhu G , Li X , Huang J , Guo X , Luan C , Kang D , Chen L , Xiao Z , Guo Z , Zeng H , Chen D , Sang Z , Ge G |
| Ref : Acta Pharm Sin B , 15 :5312 , 2025 |
| Abstract : |
| PubMedSearch : Zhang_2025_Acta.Pharm.Sin.B_15_5312 |
| PubMedID: 41132852 |