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Promethazine

Tricyclic amine-containing compound || Promethazine is a phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.Promethazine has antiemetic and antihistaminic properties. Promethazine antagonizes the central and peripheral effects of histamine mediated by histamine H1 receptors. The effects include bronchoconstriction, vasodilation and spasmodic contractions of gastrointestinal smooth muscle. In addition, this agent binds to muscarinic receptors, resulting in anticholinergic and antiemetic activities.

General

Type : Phenothiazine, Drug, Not A\/B H target, Muscarinic antagonist, Sulfur Compound

Chemical_Nomenclature : 10-[2-(dimethylamino)propyl]phenothiazine

Canonical SMILES : CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C

InChI : InChI=1S\/C17H20N2S\/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19\/h4-11,13H,12H2,1-3H3

InChIKey : PWWVAXIEGOYWEE-UHFFFAOYSA-N

Other name(s) : promethazine  ||  Proazamine  ||  Diphergan  ||  Promethazin  ||  Isophenergan  ||  Phenargan  ||  CHEMBL643  ||  CHEBI:8461  ||  SCHEMBL4700  ||  RP-3277

MW : 320.90

Formula : C17H20N2S

CAS_number : 58-33-3,    60-87-7

PubChem : 4927

UniChem : PWWVAXIEGOYWEE-UHFFFAOYSA-N

IUPHAR : 7282

Wikipedia : Promethazine

Target

Families : Promethazine ligand of proteins in family
ACHE BCHE

References (2)

Title : Repurposing promethazine hydrochloride to inhibit biofilm formation against Burkholderia thailandensis - Xu_2024_Med.Microbiol.Immunol_213_16
Author(s) : Xu KZ , You C , Wang YJ , Dar OI , Yin LJ , Xiang SL , Jia AQ
Ref : Med Microbiol Immunol , 213 :16 , 2024
Abstract :
PubMedSearch : Xu_2024_Med.Microbiol.Immunol_213_16
PubMedID: 39033094

Title : Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors - Radic_1993_Biochemistry_32_12074
Author(s) : Radic Z , Pickering NA , Vellom DC , Camp S , Taylor P
Ref : Biochemistry , 32 :12074 , 1993
Abstract :
PubMedSearch : Radic_1993_Biochemistry_32_12074
PubMedID: 8218285