Pyrrolidino-sulfonyl-indole-carbothioamide-Cpd7h
IC50 microM AChE 0.10 +/- 0.01; IC50 BChE 17.27 +/- 1.74; Ki AChE 0.08 +/- 0.01; Ki BChE 7.27 +/- 0.84
General
Type : Sulfur Compound, Pyrrolidine, Indole, Sulfonamide, Urea derivative, Carbothioamide
Chemical_Nomenclature : (E)-N-(4-fluorophenyl)-2-((1-(4-(pyrrolidin-1-ylsulfonyl)benzyl)-1H-indol-3-yl)methylene)hydrazinecarbothioamide
Canonical SMILES : C1(=CC=C(C=C1)NC(NN=CC2=C[N](C3=CC=CC=C23)CC4=CC=C(C=C4)[S](=O)(=O)N5CCCC5)=S)F
InChI : InChI=1S\/C27H26FN5O2S2\/c28-22-9-11-23(12-10-22)30-27(36)31-29-17-21-19-32(26-6-2-1-5-25(21)26)18-20-7-13-24(14-8-20)37(34,35)33-15-3-4-16-33\/h1-2,5-14,17,19H,3-4,15-16,18H2,(H2,30,31,36)
InChIKey : FPXAKEUFSFMYMQ-UHFFFAOYSA-N
Other name(s) : Compound 7h
Target
Families : Pyrrolidino-sulfonyl-indole-carbothioamide-Cpd7h ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Dual targeting of neuroblastoma and cholinesterase by morpholino\/pyrrolidino-sulfonyl-indole thiosemicarbazones: Synthesis, characterization, enzyme inhibition, cytotoxicity, docking and dynamics studies - Batool_2025_Bioorg.Chem_167_109252 |
| Author(s) : Batool Z , Toraman GO A , Cakir F , Topcu G , Taslimi P , Alharthy RD , Khan A , Al-Harrasi A , Shafiq Z , Senol H |
| Ref : Bioorg Chem , 167 :109252 , 2025 |
| Abstract : |
| PubMedSearch : Batool_2025_Bioorg.Chem_167_109252 |
| PubMedID: 41260066 |