QST-0837
IC50 0.2 nM human-MGLL clearance rate low at neutral condition, clearance rate rapid at acidic condition
General
Type : PET probe, Carbamate, Trifluoro, Azetidine, Pyrazole
Chemical_Nomenclature : 1,1,1,3,3,3-hexafluoropropan-2-yl 3-(1-phenylpyrazol-3-yl)azetidine-1-carboxylate
Canonical SMILES : C1C(CN1C(=O)OC(C(F)(F)F)C(F)(F)F)C2=NN(C=C2)C3=CC=CC=C3
InChI : InChI=1S\/C16H13F6N3O2\/c17-15(18,19)13(16(20,21)22)27-14(26)24-8-10(9-24)12-6-7-25(23-12)11-4-2-1-3-5-11\/h1-7,10,13H,8-9H2
InChIKey : ZWEMGIQYCJPRLW-UHFFFAOYSA-N
Other name(s) : QST-0837 || 1,1,1,3,3,3-hexafluoropropan-2-yl-3-(1-phenyl-1H-pyrazol-3-yl)azetidine-1-[11C]carboxylate || CHEMBL4059676 || BDBM50250848 || PD127858 || [11C]QST-0837
MW : 393.28
Formula : C16H13F6N3O2
CAS_number :
PubChem : 137635585
UniChem : ZWEMGIQYCJPRLW-UHFFFAOYSA-N
Target
Families : QST-0837 ligand of proteins in family
Monoglyceridelipase_lysophospholip
Protein :
human-MGLL
References (1)
| Title : Potential for in vivo visualization of intracellular pH gradient in the brain using PET imaging - Yamasaki_2024_Brain.Commun_6_fcae172 |
| Author(s) : Yamasaki T , Mori W , Ohkubo T , Hiraishi A , Zhang Y , Kurihara Y , Nengaki N , Tashima H , Fujinaga M , Zhang MR |
| Ref : Brain Commun , 6 :fcae172 , 2024 |
| Abstract : |
| PubMedSearch : Yamasaki_2024_Brain.Commun_6_fcae172 |
| PubMedID: 38863573 |
| Gene_locus related to this paper: human-MGLL |