Quinoline-ferulicacid-bromobenzyl-Cpd10f
IC50 AChE 0.62 +/- 0.17 microM; BChE 1.18 +/- 0.14 microM
General
Chemical_Nomenclature : (E)-3-(4-((4-bromobenzyl)oxy)-3-methoxyphenyl)-N-(2-((2-methylquinolin-4-yl)amino)ethyl)acrylamide
Canonical SMILES : N(CCNC(C=CC1=CC(=C(C=C1)OCC2=CC=C(C=C2)Br)OC)=O)C3=CC(=NC4=CC=CC=C34)C
InChI : InChI=1S\/C29H28BrN3O3\/c1-20-17-26(24-5-3-4-6-25(24)33-20)31-15-16-32-29(34)14-10-21-9-13-27(28(18-21)35-2)36-19-22-7-11-23(30)12-8-22\/h3-14,17-18H,15-16,19H2,1-2H3,(H,31,33)(H,32,34)
InChIKey : CTTUPJOFMMRTAS-UHFFFAOYSA-N
Other name(s) : Compound 10f
Target
Families : Quinoline-ferulicacid-bromobenzyl-Cpd10f ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Design, synthesis, biological evaluation, and molecular modeling studies of quinoline-ferulic acid hybrids as cholinesterase inhibitors - Mo_2019_Bioorg.Chem_93_103310 |
| Author(s) : Mo J , Yang H , Chen T , Li Q , Lin H , Feng F , Liu W , Qu W , Guo Q , Chi H , Chen Y , Sun H |
| Ref : Bioorg Chem , 93 :103310 , 2019 |
| Abstract : |
| PubMedSearch : Mo_2019_Bioorg.Chem_93_103310 |
| PubMedID: 31586704 |