Pro drug of Sitagliptin (cetagliptin) carboxylate
Type : Drug, Gliptin, Triazol, Trifluoro, Pro-Drug, Imidazole
Chemical_Nomenclature : methyl 7-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(trifluoromethyl)-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-1-carboxylate
Canonical SMILES : COC(=O)C1=C2CN(CCN2C(=N1)C(F)(F)F)C(=O)CC(CC3=CC(=C(C=C3F)F)F)N
InChI : InChI=1S\/C19H18F6N4O3\/c1-32-17(31)16-14-8-28(2-3-29(14)18(27-16)19(23,24)25)15(30)6-10(26)4-9-5-12(21)13(22)7-11(9)20\/h5,7,10H,2-4,6,8,26H2,1H3\/t10-\/m1\/s1
InChIKey : WIIAMRXFUJLYEF-SNVBAGLBSA-N
Other name(s) : SP-2086, SP2086, 328C4R3P9L
MW : 464.4
Formula : C19H18F6N4O3
CAS_number : 1174122-54-3
PubChem : 44193830
UniChem : WIIAMRXFUJLYEF-SNVBAGLBSA-N
Families : Retagliptin ligand of proteins in family
DPP4N_Peptidase_S9
Protein :
human-DPP4
Title : Retagliptin as add-on therapy to metformin in Chinese patients with type 2 diabetes inadequately controlled with metformin: A multicentre, randomized, double-blind, placebo-controlled, phase 3 trial - Guo_2024_Diabetes.Obes.Metab__ |
Author(s) : Guo L , Tian F , Liu L , Chen M , Jiang C , Li S , Liu C , Zhang Y , Qin J , Yu D , Zong Y , Dai W |
Ref : Diabetes Obes Metab , : , 2024 |
PubMedID: 38602409 |
Title : Combination of retagliptin and henagliflozin as add-on therapy to metformin in patients with type 2 diabetes inadequately controlled with metformin: A multicentre, randomized, double-blind, active-controlled, phase 3 trial - Wang_2024_Diabetes.Obes.Metab__ |
Author(s) : Wang W , Guo X , Zhang C , Ning T , Ma G , Huang Y , Jia R , Zhou D , Cao M , Zhang T , Yao L , Yuan J , Chen L , Wang Y , Jiang C , Dong X , Chen M , Gu Q , Zhang L , Fu Y , Pan T , Bi Y , Song W , Xu J , Lu W , Sun X , Ye Z , Zhang D , Peng L , Lin X , Dai W , Wang Q , Yang W |
Ref : Diabetes Obes Metab , : , 2024 |
PubMedID: 38221859 || 38618970 |