SCHEMBL6685995-3SA-f
BChE Ki of 24.20 +/- 2.26 nM; Ki ALR2 11.33 +/- 1.10 nM; Ki AChE 0.9883 72.33 +/- 3.75 || ALR2 is responsible for catalyzing the NADPH-dependent reduction of glucose to sorbitol. P15121 ALDR_HUMAN Aldo-keto reductase family 1 member B1 AKR1B1, ALDR1, ALR2
General
Type : Sulfur Compound, Sulfonamide, Urea derivative, ALR2 inhibitor, Multitarget
Chemical_Nomenclature : 1-(3,4-dichlorophenyl)-3-(3-sulfamoylphenyl)urea || 3-[3-(3,4-Dichlorophenyl)ureido]benzenesulfonamide
Canonical SMILES : C1=CC(=CC(=C1)S(=O)(=O)N)NC(=O)NC2=CC(=C(C=C2)Cl)Cl
InChI : InChI=1S\/C13H11Cl2N3O3S\/c14-11-5-4-9(7-12(11)15)18-13(19)17-8-2-1-3-10(6-8)22(16,20)21\/h1-7H,(H2,16,20,21)(H2,17,18,19)
InChIKey : YCJWPPIOSGNRDI-UHFFFAOYSA-N
Other name(s) : SCHEMBL6685995 || 3SA-f
MW : 360.2
Formula : C13H11Cl2N3O3S
CAS_number :
PubChem : 10570487
UniChem : YCJWPPIOSGNRDI-UHFFFAOYSA-N
Target
Families : SCHEMBL6685995-3SA-f ligand of proteins in family
BCHE
ACHE
Protein :
human-BCHE
human-ACHE
References (1)
| Title : Molecular and structural characterization of ureido-benzenesulfonamides as dual inhibitors of aldose reductase and cholinesterases - Turkes_2025_Arch.Biochem.Biophys_773_110594 |
| Author(s) : Turkes C , Lolak N , Duran HE , Yapar G , Akocak S |
| Ref : Archives of Biochemistry & Biophysics , 773 :110594 , 2025 |
| Abstract : |
| PubMedSearch : Turkes_2025_Arch.Biochem.Biophys_773_110594 |
| PubMedID: 40818624 |