Salidroside
Salidroside from Rhodiola plants, known for its adaptogenic, antioxidant, and neuroprotective effects, helping the body resist stress and improve function Also used as substrate for synthesis of novel salidroside esters by lipase-mediated acylation with various functional acyl groups
General
Type : Natural, Alkaloid, Glycoside, Antioxidant
Chemical_Nomenclature : (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[2-(4-hydroxyphenyl)ethoxy]oxane-3,4,5-triol
Canonical SMILES : C1=CC(=CC=C1CCO[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)O
InChI : InChI=1S\/C14H20O7\/c15-7-10-11(17)12(18)13(19)14(21-10)20-6-5-8-1-3-9(16)4-2-8\/h1-4,10-19H,5-7H2\/t10-,11-,12+,13-,14-\/m1\/s1
InChIKey : ILRCGYURZSFMEG-RKQHYHRCSA-N
Other name(s) : Rhodioloside || Rhodosin || sallidroside || Glc(b)-O-EtPh(4-OH) || [2-(4-hydroxyphenyl)ethyl] beta-D-gluco-hexopyranoside || RefChem:48959 || CHEMBL465208 || SCHEMBL148079 || CHEBI:9009
MW : 300
Formula : C14H20O7
CAS_number : 10338-51-9
PubChem : 159278
UniChem : ILRCGYURZSFMEG-RKQHYHRCSA-N
Target
Families : Salidroside ligand of proteins in family
Pancreatic_lipase
Canar_LipB
Protein :
human-PNLIP
canar-LipB
References (15)
| Title : Insights into the dual inhibitory effects of phenylethanoid glycosides from Osmanthus fragrans flower on glycolipid metabolizing enzymes - Li_2025_Bioorg.Chem_168_109328 |
| Author(s) : Li W , Qiu G , Kang M , Zhang C , Quan W , Zhou H , Fan X , Luo J , Lu B , Li M |
| Ref : Bioorg Chem , 168 :109328 , 2025 |
| Abstract : |
| PubMedSearch : Li_2025_Bioorg.Chem_168_109328 |
| PubMedID: 41401698 |
| Title : Insights into the dual inhibitory effects of phenylethanoid glycosides from Osmanthus fragrans flower on glycolipid metabolizing enzymes - Li_2025_Bioorg.Chem_168_109328 |
| Author(s) : Li W , Qiu G , Kang M , Zhang C , Quan W , Zhou H , Fan X , Luo J , Lu B , Li M |
| Ref : Bioorg Chem , 168 :109328 , 2025 |
| Abstract : |
| PubMedSearch : Li_2025_Bioorg.Chem_168_109328 |
| PubMedID: 41401698 |
| Title : Insights into the dual inhibitory effects of phenylethanoid glycosides from Osmanthus fragrans flower on glycolipid metabolizing enzymes - Li_2025_Bioorg.Chem_168_109328 |
| Author(s) : Li W , Qiu G , Kang M , Zhang C , Quan W , Zhou H , Fan X , Luo J , Lu B , Li M |
| Ref : Bioorg Chem , 168 :109328 , 2025 |
| Abstract : |
| PubMedSearch : Li_2025_Bioorg.Chem_168_109328 |
| PubMedID: 41401698 |
| Title : Salidroside attenuates beta amyloid-induced cognitive deficits via modulating oxidative stress and inflammatory mediators in rat hippocampus - Zhang_2013_Behav.Brain.Res_244C_70 |
| Author(s) : Zhang J , Zhena YF , Pu Bu Ci R , Song LG , Kong WN , Shao TM , Li X , Chai XQ |
| Ref : Behavioural Brain Research , 244C :70 , 2013 |
| Abstract : |
| PubMedSearch : Zhang_2013_Behav.Brain.Res_244C_70 |
| PubMedID: 23396166 |
| Title : Salidroside attenuates beta amyloid-induced cognitive deficits via modulating oxidative stress and inflammatory mediators in rat hippocampus - Zhang_2013_Behav.Brain.Res_244C_70 |
| Author(s) : Zhang J , Zhena YF , Pu Bu Ci R , Song LG , Kong WN , Shao TM , Li X , Chai XQ |
| Ref : Behavioural Brain Research , 244C :70 , 2013 |
| Abstract : |
| PubMedSearch : Zhang_2013_Behav.Brain.Res_244C_70 |
| PubMedID: 23396166 |
| Title : Salidroside attenuates beta amyloid-induced cognitive deficits via modulating oxidative stress and inflammatory mediators in rat hippocampus - Zhang_2013_Behav.Brain.Res_244C_70 |
| Author(s) : Zhang J , Zhena YF , Pu Bu Ci R , Song LG , Kong WN , Shao TM , Li X , Chai XQ |
| Ref : Behavioural Brain Research , 244C :70 , 2013 |
| Abstract : |
| PubMedSearch : Zhang_2013_Behav.Brain.Res_244C_70 |
| PubMedID: 23396166 |
| Title : Salidroside stimulates the accumulation of HIF-1alpha protein resulted in the induction of EPO expression: a signaling via blocking the degradation pathway in kidney and liver cells - Zheng_2012_Eur.J.Pharmacol_679_34 |
| Author(s) : Zheng KY , Zhang ZX , Guo AJ , Bi CWC , Zhu KY , Xu SL , Zhan JY , Lau DT , Dong TTX , Choi RC , Tsim KWK |
| Ref : European Journal of Pharmacology , 679 :34 , 2012 |
| Abstract : |
| PubMedSearch : Zheng_2012_Eur.J.Pharmacol_679_34 |
| PubMedID: 22309741 |
| Title : Salidroside stimulates the accumulation of HIF-1alpha protein resulted in the induction of EPO expression: a signaling via blocking the degradation pathway in kidney and liver cells - Zheng_2012_Eur.J.Pharmacol_679_34 |
| Author(s) : Zheng KY , Zhang ZX , Guo AJ , Bi CWC , Zhu KY , Xu SL , Zhan JY , Lau DT , Dong TTX , Choi RC , Tsim KWK |
| Ref : European Journal of Pharmacology , 679 :34 , 2012 |
| Abstract : |
| PubMedSearch : Zheng_2012_Eur.J.Pharmacol_679_34 |
| PubMedID: 22309741 |
| Title : Salidroside stimulates the accumulation of HIF-1alpha protein resulted in the induction of EPO expression: a signaling via blocking the degradation pathway in kidney and liver cells - Zheng_2012_Eur.J.Pharmacol_679_34 |
| Author(s) : Zheng KY , Zhang ZX , Guo AJ , Bi CWC , Zhu KY , Xu SL , Zhan JY , Lau DT , Dong TTX , Choi RC , Tsim KWK |
| Ref : European Journal of Pharmacology , 679 :34 , 2012 |
| Abstract : |
| PubMedSearch : Zheng_2012_Eur.J.Pharmacol_679_34 |
| PubMedID: 22309741 |
| Title : Synthesis of novel salidroside esters by lipase-mediated acylation with various functional acyl groups - Yu_2008_J.Biosci.Bioeng_106_65 |
| Author(s) : Yu HL , Xu JH , Su JH , Lu WY , Lin GQ |
| Ref : J Biosci Bioeng , 106 :65 , 2008 |
| Abstract : |
| PubMedSearch : Yu_2008_J.Biosci.Bioeng_106_65 |
| PubMedID: 18691533 |
| Title : Synthesis of novel salidroside esters by lipase-mediated acylation with various functional acyl groups - Yu_2008_J.Biosci.Bioeng_106_65 |
| Author(s) : Yu HL , Xu JH , Su JH , Lu WY , Lin GQ |
| Ref : J Biosci Bioeng , 106 :65 , 2008 |
| Abstract : |
| PubMedSearch : Yu_2008_J.Biosci.Bioeng_106_65 |
| PubMedID: 18691533 |
| Title : Synthesis of novel salidroside esters by lipase-mediated acylation with various functional acyl groups - Yu_2008_J.Biosci.Bioeng_106_65 |
| Author(s) : Yu HL , Xu JH , Su JH , Lu WY , Lin GQ |
| Ref : J Biosci Bioeng , 106 :65 , 2008 |
| Abstract : |
| PubMedSearch : Yu_2008_J.Biosci.Bioeng_106_65 |
| PubMedID: 18691533 |
| Title : Hepatoprotective phenolic constituents of Rhodiola sachalinensis on tacrine-induced cytotoxicity in Hep G2 cells - Song_2003_Phytother.Res_17_563 |
| Author(s) : Song EK , Kim JH , Kim JS , Cho H , Nan JX , Sohn DH , Ko GI , Oh H , Kim YC |
| Ref : Phytother Res , 17 :563 , 2003 |
| Abstract : |
| PubMedSearch : Song_2003_Phytother.Res_17_563 |
| PubMedID: 12749001 |
| Title : Hepatoprotective phenolic constituents of Rhodiola sachalinensis on tacrine-induced cytotoxicity in Hep G2 cells - Song_2003_Phytother.Res_17_563 |
| Author(s) : Song EK , Kim JH , Kim JS , Cho H , Nan JX , Sohn DH , Ko GI , Oh H , Kim YC |
| Ref : Phytother Res , 17 :563 , 2003 |
| Abstract : |
| PubMedSearch : Song_2003_Phytother.Res_17_563 |
| PubMedID: 12749001 |
| Title : Hepatoprotective phenolic constituents of Rhodiola sachalinensis on tacrine-induced cytotoxicity in Hep G2 cells - Song_2003_Phytother.Res_17_563 |
| Author(s) : Song EK , Kim JH , Kim JS , Cho H , Nan JX , Sohn DH , Ko GI , Oh H , Kim YC |
| Ref : Phytother Res , 17 :563 , 2003 |
| Abstract : |
| PubMedSearch : Song_2003_Phytother.Res_17_563 |
| PubMedID: 12749001 |