Tacrine-methyl-naphthalen-sulfonyl-piperazin-methanone-Cpd6j
IC50 eleel AChE 7.40 nM
General
Type : Sulfur Compound, Sulfonamide, Derivative of Tacrine, Acridine, Piperazine, Naphthalen
Chemical_Nomenclature : (9-amino-1,2,3,4-tetrahydroacridin-2-yl)(3-methyl-4-(naphthalen-2-yl)sulfonyl)piperazin-1-yl)methanone
Canonical SMILES : C1=CC=C2C(=C1)C(=C3C(=N2)CCC(C3)C(N4CCN(C(C4)C)[S](C5=CC=C6C(=C5)C=CC=C6)(=O)=O)=O)N
InChI : InChI=1S\/C29H30N4O3S\/c1-19-18-32(14-15-33(19)37(35,36)23-12-10-20-6-2-3-7-21(20)16-23)29(34)22-11-13-27-25(17-22)28(30)24-8-4-5-9-26(24)31-27\/h2-10,12,16,19,22H,11,13-15,17-18H2,1H3,(H2,30,31)
InChIKey : DLMARJFXDSSTEG-UHFFFAOYSA-N
Other name(s) : Compound 6j
Target
Families : Tacrine-methyl-naphthalen-sulfonyl-piperazin-methanone-Cpd6j ligand of proteins in family
ACHE
References (1)
| Title : Design, synthesis and biological evaluation of tacrine-sulphonamide hybrids as a potent acetylcholinesterase inhibitor - Reddy_2026_RSC.Adv_16_18061 |
| Author(s) : Reddy MM , Reddy EK , J A , Dev RR , Kadambari VSN , Anwar S |
| Ref : RSC Adv , 16 :18061 , 2026 |
| Abstract : |
| PubMedSearch : Reddy_2026_RSC.Adv_16_18061 |
| PubMedID: 42293127 |