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Terphenyl-Bistacrine

IC50 AChE 334 +/- 16 nM; IC50 BCHE 8.79 +/- 0.85 nM; IC50 BACE-1 0.84 +/- 0.10 micro M; Abeta aggregation AChE-induced 49.6 +/- 1.2 [%] Abeta self aggregation 50.1 +/- 2.6 [%]

General

Type : Derivative of Tacrine, Acridine

Chemical_Nomenclature : 4,4-Bis[(1,2,3,4-tetrahydroacridin-9-yl)aminomethyl]-[1,1\;4,1]terphenyl dihydrochloride

Canonical SMILES : C1=CC2=C(C=C1)C(=C3C(=N2)CCCC3)NCC4=CC=C(C=C4)C5=CC=C(C=C5)C9=CC=C(CNC6=C8C(=NC7=C6C=CC=C7)CCCC8)C=C9

InChI : InChI=1S\/C46H42N4\/c1-5-13-41-37(9-1)45(38-10-2-6-14-42(38)49-41)47-29-31-17-21-33(22-18-31)35-25-27-36(28-26-35)34-23-19-32(20-24-34)30-48-46-39-11-3-7-15-43(39)50-44-16-8-4-12-40(44)46\/h1,3,5,7,9,11,13,15,17-28H,2,4,6,8,10,12,14,16,29-30H2,(H,47,49)(H,48,50)

InChIKey : NTMXBPIBGBIYER-UHFFFAOYSA-N

Other name(s) :

MW : 650.865

Formula : C46H42N4

CAS_number :

PubChem :

UniChem : NTMXBPIBGBIYER-UHFFFAOYSA-N

Target

Families : Terphenyl-Bistacrine ligand of proteins in family
ACHE BCHE

References (1)

Title : Bis(7)-tacrine derivatives as multitarget-directed ligands: Focus on anticholinesterase and antiamyloid activities -
Author(s) : Bolognesi ML , Bartolini M , Mancini F , Chiriano G , Ceccarini L , Rosini M , Milelli A , Tumiatti V , Andrisano V , Melchiorre C
Ref : ChemMedChem , 5 :1215 , 2010
PubMedID: 20486153