Thioflavin-T
General
Type : Quaternary compound, Benzothiazol, Sulfur Compound
Chemical_Nomenclature : 2-[4-(dimethylamino)phenyl]-3-methyl-1,3-benzothiazol-3-ium-6-ol
Canonical SMILES : C[N+]1=C(SC2=C1C=CC(=C2)O)C3=CC=C(C=C3)N(C)C
InChI : InChI=1S\/C16H16N2OS\/c1-17(2)12-6-4-11(5-7-12)16-18(3)14-9-8-13(19)10-15(14)20-16\/h4-10H,1-3H3\/p+1
InChIKey : NOVJJPLRUMZSDK-UHFFFAOYSA-O
Other name(s) : 2-[4-(Dimethylamino)phenyl]-6-Hydroxy-3-Methyl-1,3-Benzothiazol-3-Ium || DB08615 || TFL || Thioflavin T || Basic yellow 1
MW : 285.38
Formula : C16H17N2OS+
CAS_number : 2390-54-7
PubChem : 24832019
UniChem : NOVJJPLRUMZSDK-UHFFFAOYSA-O
Wikipedia : Thioflavin
Target
Families : Thioflavin-T ligand of proteins in family
ACHE
BCHE
Protein :
human-BCHE
torca-ACHE
References (2)
| Title : Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study - Rosenberry_2017_Molecules_22_ |
| Author(s) : Rosenberry TL , Brazzolotto X , Macdonald IR , Wandhammer M , Trovaslet-Leroy M , Darvesh S , Nachon F |
| Ref : Molecules , 22 : , 2017 |
| Abstract : |
| PubMedSearch : Rosenberry_2017_Molecules_22_ |
| PubMedID: 29186056 |
| Gene_locus related to this paper: human-BCHE |
| Title : Crystal structure of thioflavin T bound to the peripheral site of Torpedo californica acetylcholinesterase reveals how thioflavin T acts as a sensitive fluorescent reporter of ligand binding to the acylation site - Harel_2008_J.Am.Chem.Soc_130_7856 |
| Author(s) : Harel M , Sonoda LK , Silman I , Sussman JL , Rosenberry TL |
| Ref : Journal of the American Chemical Society , 130 :7856 , 2008 |
| Abstract : |
| PubMedSearch : Harel_2008_J.Am.Chem.Soc_130_7856 |
| PubMedID: 18512913 |
| Gene_locus related to this paper: torca-ACHE |