Tilorone
Tilorone is a orally available small molecule interferon inducer that is used as an antiviral agent. Selective alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonist. Inhibits eel and human AChE with IC(50)'s of 14.4 nM and 64.4 nM, respectively, but does not inhibit BuChE IC(50) > 50 microM
General
Chemical_Nomenclature : 2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one
Canonical SMILES : CCN(CC)CCOC1=CC2=C(C=C1)C3=C(C2=O)C=C(C=C3)OCCN(CC)CC
InChI : InChI=1S\/C25H34N2O3\/c1-5-26(6-2)13-15-29-19-9-11-21-22-12-10-20(30-16-14-27(7-3)8-4)18-24(22)25(28)23(21)17-19\/h9-12,17-18H,5-8,13-16H2,1-4H3
InChIKey : MPMFCABZENCRHV-UHFFFAOYSA-N
Other name(s) : Bis-DEAE-fluorenone || Tilorona || Tiloronum || Amiksin || Amixin || Amyxin || Bis DEAE Fluorenone || Hydrochloride, Tilorone || Tilorone || Tilorone Hydrochloride || CHEMBL47298 || SCHEMBL35240 || CHEBI:109553 || CHEBI:147347 || ZINC538461
MW : 410.5
Formula : C25H34N2O3
CAS_number : 27591-97-5
PubChem : 5475
UniChem : MPMFCABZENCRHV-UHFFFAOYSA-N
Target
Families : Tilorone ligand of proteins in family
ACHE
Protein :
human-ACHE
References (3)
| Title : The Antiviral Drug Tilorone Is a Potent and Selective Inhibitor of Acetylcholinesterase - Vignaux_2021_Chem.Res.Toxicol__ |
| Author(s) : Vignaux PA , Minerali E , Lane TR , Foil DH , Madrid PB , Puhl AC , Ekins S |
| Ref : Chemical Research in Toxicology , : , 2021 |
| Abstract : |
| PubMedSearch : Vignaux_2021_Chem.Res.Toxicol__ |
| PubMedID: 33400519 |
| Title : SAR of alpha7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophore - Schrimpf_2012_Bioorg.Med.Chem.Lett_22_1633 |
| Author(s) : Schrimpf MR , Sippy KB , Briggs CA , Anderson DJ , Li T , Ji J , Frost JM , Surowy CS , Bunnelle WH , Gopalakrishnan M , Meyer MD |
| Ref : Bioorganic & Medicinal Chemistry Lett , 22 :1633 , 2012 |
| Abstract : |
| PubMedSearch : Schrimpf_2012_Bioorg.Med.Chem.Lett_22_1633 |
| PubMedID: 22281189 |
| Title : alpha7 nicotinic acetylcholine receptor agonist properties of tilorone and related tricyclic analogues - Briggs_2008_Br.J.Pharmacol_153_1054 |
| Author(s) : Briggs CA , Schrimpf MR , Anderson DJ , Gubbins EJ , Gronlien JH , Hakerud M , Ween H , Thorin-Hagene K , Malysz J , Li J , Bunnelle WH , Gopalakrishnan M , Meyer MD |
| Ref : British Journal of Pharmacology , 153 :1054 , 2008 |
| Abstract : |
| PubMedSearch : Briggs_2008_Br.J.Pharmacol_153_1054 |
| PubMedID: 18157163 |