Valpromide
also inhibitor of Limonene-1,2-epoxide hydrolase (not alpha/beta hydrolase) Valpromide is a prodrug of valproic acid. Valpromide has been used as an antiepileptic and antipsychotic drug. Inhibitor of microsomal but not soluble epoxyde hydrolases
General
Type : Drug, Carboxamide
Chemical_Nomenclature : 2-propylpentanamide
Canonical SMILES : CCCC(CCC)C(=O)N
InChI : InChI=1S\/C8H17NO\/c1-3-5-7(6-4-2)8(9)10\/h7H,3-6H2,1-2H3,(H2,9,10)
InChIKey : OMOMUFTZPTXCHP-UHFFFAOYSA-N
Other name(s) : Depamide || 2-PROPYLPENTANAMIDE || Dipropylacetamide || 2-Propylvaleramide || Valpramide
MW : 143.22
Formula : C8H17NO
CAS_number : 2430-27-5
PubChem : 71113
UniChem : OMOMUFTZPTXCHP-UHFFFAOYSA-N
Target
Families : Valpromide ligand of proteins in family
Epoxide_hydrolase
Protein :
soltu-3epoxy
aspni-hyl1
human-EPHX1
References (7)
| Title : Structural insights into human microsomal epoxide hydrolase by combined homology modeling, molecular dynamics simulations, and molecular docking calculations - Saenz-Mendez_2017_Proteins_85_720 |
| Author(s) : Saenz-Mendez P , Katz A , Perez-Kempner ML , Ventura ON , Vazquez M |
| Ref : Proteins , 85 :720 , 2017 |
| Abstract : |
| PubMedSearch : Saenz-Mendez_2017_Proteins_85_720 |
| PubMedID: 28120429 |
| Title : Prediction of drug-drug interactions with carbamazepine-10,11-epoxide using a new in vitro assay for epoxide hydrolase inhibition - Rosa_2016_Xenobiotica_46_1076 |
| Author(s) : Rosa M , Bonnaillie P , Chanteux H |
| Ref : Xenobiotica , 46 :1076 , 2016 |
| Abstract : |
| PubMedSearch : Rosa_2016_Xenobiotica_46_1076 |
| PubMedID: 26936324 |
| Title : Directed evolution of an enantioselective epoxide hydrolase: uncovering the source of enantioselectivity at each evolutionary stage - Reetz_2009_J.Am.Chem.Soc_131_7334 |
| Author(s) : Reetz MT , Bocola M , Wang LW , Sanchis J , Cronin A , Arand M , Zou J , Archelas A , Bottalla AL , Naworyta A , Mowbray SL |
| Ref : Journal of the American Chemical Society , 131 :7334 , 2009 |
| Abstract : |
| PubMedSearch : Reetz_2009_J.Am.Chem.Soc_131_7334 |
| PubMedID: 19469578 |
| Gene_locus related to this paper: aspni-hyl1 |
| Title : X-ray structure of potato epoxide hydrolase sheds light on substrate specificity in plant enzymes - Mowbray_2006_Protein.Sci_15_1628 |
| Author(s) : Mowbray SL , Elfstrom LT , Ahlgren KM , Andersson CE , Widersten M |
| Ref : Protein Science , 15 :1628 , 2006 |
| Abstract : |
| PubMedSearch : Mowbray_2006_Protein.Sci_15_1628 |
| PubMedID: 16751602 |
| Gene_locus related to this paper: soltu-3epoxy |
| Title : Structure of Rhodococcus erythropolis limonene-1,2-epoxide hydrolase reveals a novel active site - Arand_2003_EMBO.J_22_2583 |
| Author(s) : Arand M , Hallberg BM , Zou J , Bergfors T , Oesch F , van der Werf MJ , de Bont JA , Jones TA , Mowbray SL |
| Ref : EMBO Journal , 22 :2583 , 2003 |
| Abstract : |
| PubMedSearch : Arand_2003_EMBO.J_22_2583 |
| PubMedID: 12773375 |
| Title : Structure activity relationship of human microsomal epoxide hydrolase inhibition by amide and acid analogues of valproic acid - Spiegelstein_2000_Pharm.Res_17_216 |
| Author(s) : Spiegelstein O , Kroetz DL , Levy RH , Yagen B , Hurst SI , Levi M , Haj-Yehia A , Bialer M |
| Ref : Pharm Res , 17 :216 , 2000 |
| Abstract : |
| PubMedSearch : Spiegelstein_2000_Pharm.Res_17_216 |
| PubMedID: 10751038 |
| Title : Recombinant expression of human microsomal epoxide hydrolase protects V79 Chinese hamster cells from styrene oxide- but not from ethylene oxide-induced DNA strand breaks - Herrero_1997_Environ.Mol.Mutagen_30_429 |
| Author(s) : Herrero ME , Arand M , Hengstler JG , Oesch F |
| Ref : Environmental & Molecular Mutagenesis , 30 :429 , 1997 |
| Abstract : |
| PubMedSearch : Herrero_1997_Environ.Mol.Mutagen_30_429 |
| PubMedID: 9435884 |