Homo sapiens (Human) microsomal epoxide hydrolase HYEP mEH, epoxide hydratase EPHX1
Epoxide hydrolases (EC 3.3.2.3) play an important role in both the activation and detoxification of exogenous chemicals such as polycyclic aromatic hydrocarbons. Mutant form of microsomal epoxide hydrolase is the molecular basis for abnormal reactions to phenytoin (diphenylhydantoin, dilantin) and some other drugs. Hydantoin used during pregnancy for seizure prophylaxis can result in children with the fetal hydantoin syndrome (FHS)(major birth defects including congenital heart disease, cleft lip\/palate, microcephaly, and major genitourinary, eye, and limb defects) Defect in hydroxylation of diphenylhydantoin is related to a mutation in human-EPHX1 resulting in low activity. Familial hypercholanemia is characterized by elevated serum bile acid concentrations, itching, and fat malabsorption. In a patient with hypercholanemia. Zhu et al. (2003) identified compound heterozygosity for 2 mutations in the EPHX1 gene, which resulted in a significant decrease in EPHX1 promoter activity
Family : Epoxide_hydrolase
Block : X
Position in NCBI Life Tree : Homo sapiens
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N EMWLEILLTSV LGFAIYWFIS RDKEETLPLE DGWWGPGTRS AAREDDSIRP FKVETSDEEI HDLHQRIDKF RFTPPLEDSC FHYGFNSNYL KKVISYWRNE FDWKKQVEIL NRYPHFKTKI EGLDIHFIHV KPPQLPAGHT PKPLLMVHGW PGSFYEFYKI IPLLTDPKNH GLSDEHVFEV ICPSIPGYGF SEASSKKGFN SVATARIFYK LMLRLGFQEF YIQGGDWGSL ICTNMAQLVP SHVKGLHLNM ALVLSNFSTL TLLLGQRFGR FLGLTERDVE LLYPVKEKVF YSLMRESGYM HIQCTKPDTV GSALNDSPVG LAAYILEKFS TWTNTEFRYL EDGGLERKFS LDDLLTNVML YWTTGTIISS QRFYKENLGQ GWMTQKHERM KVYVPTGFSA FPFELLHTPE KWVRFKYPKL ISYSYMVRGG HFAAFEEPEL LAQDIRKFLS VLERQ
| Title : The prognostic significance of epoxide hydrolases in colorectal cancer - Cao_2025_Biochem.Biophys.Rep_41_101912 |
| Author(s) : Cao L , Ba Y , Chen F , Li D , Zhang S , Zhang H |
| Ref : Biochem Biophys Rep , 41 :101912 , 2025 |
| Abstract : |
| PubMedSearch : Cao_2025_Biochem.Biophys.Rep_41_101912 |
| PubMedID: 39850362 |
| Gene_locus related to this paper: human-EPHX1 , human-EPHX2 , human-EPHX3 , human-EPHX4 |
| Title : Epoxid hydrolase single gene polymorphism (RS1051740) and severity of chronic obstructive disease - Antonova_2022_Wiad.Lek_75_2779 |
| Author(s) : Antonova I , Gridnyev O , Galchinskaya V |
| Ref : Wiad Lek , 75 :2779 , 2022 |
| Abstract : |
| PubMedSearch : Antonova_2022_Wiad.Lek_75_2779 |
| PubMedID: 36591768 |
| Gene_locus related to this paper: human-EPHX1 |
| Title : EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence - Gautheron_2021_Elife_10_ |
| Author(s) : Gautheron J , Morisseau C , Chung WK , Zammouri J , Auclair M , Baujat G , Capel E , Moulin C , Wang Y , Yang J , Hammock BD , Cerame B , Phan F , Feve B , Vigouroux C , Andreelli F , Jeru I |
| Ref : Elife , 10 : , 2021 |
| Abstract : |
| PubMedSearch : Gautheron_2021_Elife_10_ |
| PubMedID: 34342583 |
| Gene_locus related to this paper: human-EPHX1 |
| Title : Role of epoxide hydrolases and cytochrome P450s on metabolism of KZR-616, a first-in-class selective inhibitor of the immunoproteasome - Fang_2021_Drug.Metab.Dispos__ |
| Author(s) : Fang Y , Johnson H , Anderl JL , Muchamuel T , McMinn D , Morisseau C , Hammock BD , Kirk C , Wang J |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , : , 2021 |
| Abstract : |
| PubMedSearch : Fang_2021_Drug.Metab.Dispos__ |
| PubMedID: 34234005 |
| Gene_locus related to this paper: human-EPHX1 |
| Title : Development of potent inhibitors of the human microsomal epoxide hydrolase - Barnych_2020_Eur.J.Med.Chem_193_112206 |
| Author(s) : Barnych B , Singh N , Negrel S , Zhang Y , Magis D , Roux C , Hua X , Ding Z , Morisseau C , Tantillo DJ , Siegel JB , Hammock BD |
| Ref : Eur Journal of Medicinal Chemistry , 193 :112206 , 2020 |
| Abstract : |
| PubMedSearch : Barnych_2020_Eur.J.Med.Chem_193_112206 |
| PubMedID: 32203787 |
| Gene_locus related to this paper: human-EPHX1 , mouse-EPHX1 |
| Title : Proteomic Analysis Reveals that EPHX1 Contributes to 5-Fluorouracil Resistance in a Human Hepatocellular Carcinoma Cell Line - Sun_2020_Proteomics.Clin.Appl_14_e1900080 |
| Author(s) : Sun R , Dong C , Li R , Chu H , Liu J , Hao D , Zhang L , Zhao B , Wang L , Zhang Y |
| Ref : Proteomics Clin Appl , 14 :e1900080 , 2020 |
| Abstract : |
| PubMedSearch : Sun_2020_Proteomics.Clin.Appl_14_e1900080 |
| PubMedID: 32067389 |
| Gene_locus related to this paper: human-EPHX1 |
| Title : The Tyr113His T\/C rs1051740 and 'very slow' phenotype of the EPHX1 gene alters miR-26b-5p and miR-1207-5p expression in pregnancy - Naidoo_2017_Gene_633_71 |
| Author(s) : Naidoo P , Naidoo RN , Ramkaran P , Asharam K , Chuturgoon AA |
| Ref : Gene , 633 :71 , 2017 |
| Abstract : |
| PubMedSearch : Naidoo_2017_Gene_633_71 |
| PubMedID: 28789952 |
| Gene_locus related to this paper: human-EPHX1 |
| Title : Discovery of a Novel Microsomal Epoxide Hydrolase-Catalyzed Hydration of a Spiro Oxetane - Li_2016_Drug.Metab.Dispos_44_1341 |
| Author(s) : Li XQ , Hayes MA , Gronberg G , Berggren K , Castagnoli N, Jr. , Weidolf L |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 44 :1341 , 2016 |
| Abstract : |
| PubMedSearch : Li_2016_Drug.Metab.Dispos_44_1341 |
| PubMedID: 27256986 |
| Gene_locus related to this paper: human-EPHX1 |
| Title : Development of fluorescent substrates for microsomal epoxide hydrolase and application to inhibition studies - Morisseau_2011_Anal.Biochem_414_154 |
| Author(s) : Morisseau C , Bernay M , Escaich A , Sanborn JR , Lango J , Hammock BD |
| Ref : Analytical Biochemistry , 414 :154 , 2011 |
| Abstract : |
| PubMedSearch : Morisseau_2011_Anal.Biochem_414_154 |
| PubMedID: 21371418 |
| Gene_locus related to this paper: human-EPHX1 , ratno-hyep |
| Title : Development of metabolically stable inhibitors of Mammalian microsomal epoxide hydrolase - Morisseau_2008_Chem.Res.Toxicol_21_951 |
| Author(s) : Morisseau C , Newman JW , Wheelock CE , Hill Iii T , Morin D , Buckpitt AR , Hammock BD |
| Ref : Chemical Research in Toxicology , 21 :951 , 2008 |
| Abstract : |
| PubMedSearch : Morisseau_2008_Chem.Res.Toxicol_21_951 |
| PubMedID: 18363382 |
| Gene_locus related to this paper: human-EPHX1 , ratno-hyep |
| Title : Functional analysis of human microsomal epoxide hydrolase genetic variants - Hosagrahara_2004_Chem.Biol.Interact_150_149 |
| Author(s) : Hosagrahara VP , Rettie AE , Hassett C , Omiecinski CJ |
| Ref : Chemico-Biological Interactions , 150 :149 , 2004 |
| Abstract : |
| PubMedSearch : Hosagrahara_2004_Chem.Biol.Interact_150_149 |
| PubMedID: 15535985 |
| Gene_locus related to this paper: human-EPHX1 |
| Title : Inhibition of human m-epoxide hydrolase gene expression in a case of hypercholanemia - Zhu_2003_Biochim.Biophys.Acta_1638_208 |
| Author(s) : Zhu QS , Xing W , Qian B , von Dippe P , Shneider BL , Fox VL , Levy D |
| Ref : Biochimica & Biophysica Acta , 1638 :208 , 2003 |
| Abstract : |
| PubMedSearch : Zhu_2003_Biochim.Biophys.Acta_1638_208 |
| PubMedID: 12878321 |
| Gene_locus related to this paper: human-EPHX1 |
| Title : Five novel single nucleotide polymorphisms in the EPHX1 gene encoding microsomal epoxide hydrolase - Shiseki_2003_Drug.Metab.Pharmacokinet_18_150 |
| Author(s) : Shiseki K , Itoda M , Saito Y , Nakajima Y , Maekawa K , Kimura H , Goto Y , Saitoh O , Katoh M , Ohnuma T , Kawai M , Sugai K , Ohtsuki T , Suzuki C , Minami N , Ozawa S , Sawada J |
| Ref : Drug Metab Pharmacokinet , 18 :150 , 2003 |
| Abstract : |
| PubMedSearch : Shiseki_2003_Drug.Metab.Pharmacokinet_18_150 |
| PubMedID: 15618730 |
| Gene_locus related to this paper: human-EPHX1 |
| Title : Two exonic single nucleotide polymorphisms in the microsomal epoxide hydrolase gene are jointly associated with preeclampsia - Laasanen_2002_Eur.J.Hum.Genet_10_569 |
| Author(s) : Laasanen J , Romppanen EL , Hiltunen M , Helisalmi S , Mannermaa A , Punnonen K , Heinonen S |
| Ref : Eur J Hum Genet , 10 :569 , 2002 |
| Abstract : |
| PubMedSearch : Laasanen_2002_Eur.J.Hum.Genet_10_569 |
| PubMedID: 12173035 |
| Gene_locus related to this paper: human-EPHX1 |
| Title : Identification of 6 new polymorphisms, g.11177G>A, g.14622C>T (R49C), g.17540T>C, g.17639T>C, g.30929T>C, g.31074G>A (R454Q), in the human microsomal epoxide hydrolase gene (EPHX1) in a French population - |
| Author(s) : Belmahdi F , Chevalier D , Lo-Guidice JM , Allorge D , Cauffiez C , Lafitte JJ , Broly F |
| Ref : Hum Mutat , 16 :450 , 2000 |
| PubMedID: 11058921 |
| Gene_locus related to this paper: human-EPHX1 , human-EPHX2 |
| Title : Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants - Hassett_1994_Hum.Mol.Genet_3_421 |
| Author(s) : Hassett C , Aicher L , Sidhu JS , Omiecinski CJ |
| Ref : Hum Mol Genet , 3 :421 , 1994 |
| Abstract : |
| PubMedSearch : Hassett_1994_Hum.Mol.Genet_3_421 |
| PubMedID: 7516776 |
| Gene_locus related to this paper: human-EPHX1 |
| Title : The human microsomal epoxide hydrolase gene (EPHX1): complete nucleotide sequence and structural characterization - Hassett_1994_Genomics_23_433 |
| Author(s) : Hassett C , Robinson KB , Beck NB , Omiecinski CJ |
| Ref : Genomics , 23 :433 , 1994 |
| Abstract : |
| PubMedSearch : Hassett_1994_Genomics_23_433 |
| PubMedID: 7835893 |
| Gene_locus related to this paper: human-EPHX1 |
| Title : Human microsomal xenobiotic epoxide hydrolase. Complementary DNA sequence, complementary DNA-directed expression in COS-1 cells, and chromosomal localization - Skoda_1988_J.Biol.Chem_263_1549 |
| Author(s) : Skoda RC , Demierre A , McBride OW , Gonzalez FJ , Meyer UA |
| Ref : Journal of Biological Chemistry , 263 :1549 , 1988 |
| Abstract : |
| PubMedSearch : Skoda_1988_J.Biol.Chem_263_1549 |
| PubMedID: 2891713 |
| Gene_locus related to this paper: human-EPHX1 |
| Title : Nucleotide and deduced amino acid sequence of human liver microsomal epoxide hydrolase - |
| Author(s) : Jackson MR , Craft JA , Burchell B |
| Ref : Nucleic Acids Research , 15 :7188 , 1987 |
| PubMedID: 3502697 |
| Gene_locus related to this paper: human-EPHX1 |
| Title : Partial nucleotide sequence of a cloned cDNA for human liver microsomal epoxide hydrolase. - |
| Author(s) : Craft JA , Jackson MR , Burchell B |
| Ref : Biochem Soc Trans , 15 :708 , 1987 |
| PubMedID: |
| Gene_locus related to this paper: human-EPHX1 |
| Title : Purification of human liver cytosolic epoxide hydrolase and comparison to the microsomal enzyme - Wang_1982_Biochemistry_21_5769 |
| Author(s) : Wang P , Meijer J , Guengerich FP |
| Ref : Biochemistry , 21 :5769 , 1982 |
| Abstract : |
| PubMedSearch : Wang_1982_Biochemistry_21_5769 |
| PubMedID: 6185139 |
| Gene_locus related to this paper: human-EPHX1 , human-EPHX2 |